RU95112576A - Способ получения энантиомерно чистого 6-[(4-хлорфенил)-(1h-1,2,4-триазол-1-ил)метил]-1-метил-1н-бензотриазола, промежуточные соединения для их получения и способ их получения - Google Patents

Способ получения энантиомерно чистого 6-[(4-хлорфенил)-(1h-1,2,4-триазол-1-ил)метил]-1-метил-1н-бензотриазола, промежуточные соединения для их получения и способ их получения

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Publication number
RU95112576A
RU95112576A RU95112576/04A RU95112576A RU95112576A RU 95112576 A RU95112576 A RU 95112576A RU 95112576/04 A RU95112576/04 A RU 95112576/04A RU 95112576 A RU95112576 A RU 95112576A RU 95112576 A RU95112576 A RU 95112576A
Authority
RU
Russia
Prior art keywords
methyl
preparation
benzotriazole
chlorophenyl
triazol
Prior art date
Application number
RU95112576/04A
Other languages
English (en)
Inventor
Луи Анна Вилемсан Альбер
Be]
Луи Антуан Верстапан Вальтер
Эрман Копман Алекс
Мария Жозефа Вандандриеш Анна
Гастон Мария Де Кнап Альфонс
Гастон Вене Марк
Fr]
Original Assignee
Жансен Фармасетика Н.В. (BE)
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Жансен Фармасетика Н.В. (BE), Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В. (BE)
Publication of RU95112576A publication Critical patent/RU95112576A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предлагается способ получения (+)-6-[(4-хлорфенил) (1-1,2,4 -триазол-1-ил)метил] -1-метил-1H-бензотриазола, включающий расщепление (±)-6-[(4-хлорфенил)гидразинометил]-1-метил-1H-бензотриазола и превращение проходящего энантиомерно чистого промежуточного гидразина в (+)-6-[(4-хлорфенил)(1H-1,2,4-триазол-1-ил)метил] -1-метил-1H-бензотриазол. Предложены также новые промежуточные соединения для получения целевых соединений и способы их получения.

Claims (1)

  1. Предлагается способ получения (+)-6-[(4-хлорфенил) (1-1,2,4 -триазол-1-ил)метил] -1-метил-1H-бензотриазола, включающий расщепление (±)-6-[(4-хлорфенил)гидразинометил]-1-метил-1H-бензотриазола и превращение проходящего энантиомерно чистого промежуточного гидразина в (+)-6-[(4-хлорфенил)(1H-1,2,4-триазол-1-ил)метил] -1-метил-1H-бензотриазол. Предложены также новые промежуточные соединения для получения целевых соединений и способы их получения.
RU95112576/04A 1992-11-10 1993-11-02 Способ получения энантиомерно чистого 6-[(4-хлорфенил)-(1h-1,2,4-триазол-1-ил)метил]-1-метил-1н-бензотриазола, промежуточные соединения для их получения и способ их получения RU95112576A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92203443 1992-11-10
BE92203443.4 1992-11-10

Publications (1)

Publication Number Publication Date
RU95112576A true RU95112576A (ru) 1997-03-20

Family

ID=8211029

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95112576/04A RU95112576A (ru) 1992-11-10 1993-11-02 Способ получения энантиомерно чистого 6-[(4-хлорфенил)-(1h-1,2,4-триазол-1-ил)метил]-1-метил-1н-бензотриазола, промежуточные соединения для их получения и способ их получения

Country Status (18)

Country Link
US (2) US5663354A (ru)
EP (1) EP0668861A1 (ru)
JP (1) JPH08502990A (ru)
AU (1) AU679704B2 (ru)
BG (1) BG99594A (ru)
BR (1) BR9307409A (ru)
CA (1) CA2148489A1 (ru)
CZ (1) CZ115195A3 (ru)
FI (1) FI952251A0 (ru)
HU (1) HUT72073A (ru)
NO (1) NO951808L (ru)
NZ (1) NZ257551A (ru)
PL (1) PL176059B1 (ru)
RO (1) RO114327B1 (ru)
RU (1) RU95112576A (ru)
SG (1) SG50476A1 (ru)
SK (1) SK59995A3 (ru)
WO (1) WO1994011364A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502990A (ja) * 1992-11-10 1996-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 鏡像体的に純粋な６−［（４−クロロフェニル）（１ｈ−１，２，４−トリアゾール−１−イル）メチル−１−メチル−１ｈ−ベンゾトリアゾールの製造方法
US8795629B2 (en) 2009-02-13 2014-08-05 Brookhaven Science Associates, Llc Radio-methyl vorozole and methods for making and using the same
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
CN111630005A (zh) 2018-01-03 2020-09-04 埃科莱布美国股份有限公司 作为腐蚀抑制剂的苯并三唑衍生物
CN115650962A (zh) * 2022-10-31 2023-01-31 吉林大学 一种用于钯催化偶联反应的荧光配体化合物及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ224714A (en) * 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
US4943574A (en) * 1987-06-01 1990-07-24 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl) substituted benzotriazole derivatives and pharmaceutical compositions containing them
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
JPH08502990A (ja) * 1992-11-10 1996-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 鏡像体的に純粋な６−［（４−クロロフェニル）（１ｈ−１，２，４−トリアゾール−１−イル）メチル−１−メチル−１ｈ−ベンゾトリアゾールの製造方法

Also Published As

Publication number Publication date
NZ257551A (en) 1995-10-26
CZ115195A3 (en) 1995-11-15
AU5420394A (en) 1994-06-08
WO1994011364A1 (en) 1994-05-26
SK59995A3 (en) 1995-10-11
AU679704B2 (en) 1997-07-10
PL176059B1 (pl) 1999-03-31
NO951808D0 (no) 1995-05-09
NO951808L (no) 1995-05-09
FI952251A (fi) 1995-05-09
US5663354A (en) 1997-09-02
RO114327B1 (ro) 1999-03-30
HUT72073A (en) 1996-03-28
JPH08502990A (ja) 1996-04-02
SG50476A1 (en) 1998-07-20
CA2148489A1 (en) 1994-05-26
FI952251A0 (fi) 1995-05-09
BG99594A (bg) 1996-01-31
US5746840A (en) 1998-05-05
BR9307409A (pt) 1999-08-24
PL308905A1 (en) 1995-09-04
EP0668861A1 (en) 1995-08-30

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