RU94039363A - Method of production of composite medicinal preparation in solid gelatin capsules - Google Patents

Method of production of composite medicinal preparation in solid gelatin capsules

Info

Publication number
RU94039363A
RU94039363A RU94039363/14A RU94039363A RU94039363A RU 94039363 A RU94039363 A RU 94039363A RU 94039363/14 A RU94039363/14 A RU 94039363/14A RU 94039363 A RU94039363 A RU 94039363A RU 94039363 A RU94039363 A RU 94039363A
Authority
RU
Russia
Prior art keywords
preparation
production
gelatin capsules
citrapar
composite
Prior art date
Application number
RU94039363/14A
Other languages
Russian (ru)
Other versions
RU2110258C1 (en
Inventor
В.Я. Шарков
А.Е. Полстянов
Т.И. Скоблик
Т.И. Юдина
Т.А. Устинова
М.В. Штейнгарт
В.П. Георгиевский
Н.Н. Скакун
Н.И. Гончаров
В.В. Либина
Original Assignee
Фармацевтическое акционерное общество "Ферейн"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармацевтическое акционерное общество "Ферейн" filed Critical Фармацевтическое акционерное общество "Ферейн"
Priority to RU94039363/14A priority Critical patent/RU2110258C1/en
Publication of RU94039363A publication Critical patent/RU94039363A/en
Application granted granted Critical
Publication of RU2110258C1 publication Critical patent/RU2110258C1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FIELD: chemicopharmaceutical industry, in particular, production of composite medicinal preparation of analgetic, antipyretic, anti-inflammatory effect in solid gelatin capsules. SUBSTANCE: the method of production of a stable and nontoxic medicinal form of composite preparation "Citrapar", containing acetylsalicylic acid, paracetamol, caffeine, citric acid consists in the use of powders of acting substances. Powders of acting substances are sifted, mixed with auxiliary substances and dosed into solid gelatin capsules. Talc (2.5 to 3.0%), polyvinylpyrrolidone and acrosil (0.65 to 0.7%) are used as auxiliary substances, which makes it possible to obtain a mass for filling the capsules, providing the necessary weighed portion and homogeneity of dosage. To obtain a less toxic medicinal form, paracetamol (33 to 41%) is introduced in the preparation instead of phenacetin. The offered method of production of medicinal preparation "Citrapar" in solid gelatin capsules excludes any contact of the composite mix with moisture, provides for production of medicinal preparation initially containing a lower percentage of free salicylic acid. EFFECT: the "Citrapar" powdered dosed preparation features an enhanced bioaccessibility and stability in storage.

Claims (1)

Изобретение относится к химико-фармацевтической промышленности, а именно к способу получения комбинированного лекарственного препарата анальгетического, жаропонижающего, противовоспалительного действия в твердых желатиновых капсулах. С целью получения менее токсичной лекарственной формы в состав препарата введен парацетамол в количестве 33 - 41% вместо фенацетина. Предлагаемый способ получения лекарственного препарата "Цитрапар" в твердых желатиновых капсулах исключает контакт композиционной смеси с влагой, температурой, а также отсутствует воздействие давления прессования, дает возможность получить лекарственный препарат, изначально содержащий меньший процент свободной салициловой кислоты. Полученный препарат "Цитрапар" в виде порошкообразной дозируемой формы обладает высокой биодоступностью и стабилен при хранении.The invention relates to the pharmaceutical industry, and in particular to a method for producing a combined drug of analgesic, antipyretic, anti-inflammatory action in hard gelatin capsules. In order to obtain a less toxic dosage form, paracetamol in an amount of 33 - 41% was introduced into the composition of the drug instead of phenacetin. The proposed method for the preparation of the drug "Citrapar" in hard gelatin capsules eliminates the contact of the composite mixture with moisture, temperature, and there is no pressure pressure, makes it possible to obtain a drug that initially contains a lower percentage of free salicylic acid. The resulting preparation "Citrapar" in the form of a powdered dosage form has a high bioavailability and is stable during storage.
RU94039363/14A 1994-10-20 1994-10-20 Method of preparing the combined medicinal preparation in solid gelatinous capsules RU2110258C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU94039363/14A RU2110258C1 (en) 1994-10-20 1994-10-20 Method of preparing the combined medicinal preparation in solid gelatinous capsules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU94039363/14A RU2110258C1 (en) 1994-10-20 1994-10-20 Method of preparing the combined medicinal preparation in solid gelatinous capsules

Publications (2)

Publication Number Publication Date
RU94039363A true RU94039363A (en) 1996-09-20
RU2110258C1 RU2110258C1 (en) 1998-05-10

Family

ID=20161925

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94039363/14A RU2110258C1 (en) 1994-10-20 1994-10-20 Method of preparing the combined medicinal preparation in solid gelatinous capsules

Country Status (1)

Country Link
RU (1) RU2110258C1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110954386A (en) * 2019-12-31 2020-04-03 中国计量科学研究院 Chromium element standard substance in form of medicinal hollow capsule, preparation method thereof, kit combination thereof and method for measuring chromium element content

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110954386A (en) * 2019-12-31 2020-04-03 中国计量科学研究院 Chromium element standard substance in form of medicinal hollow capsule, preparation method thereof, kit combination thereof and method for measuring chromium element content
CN110954386B (en) * 2019-12-31 2022-08-19 中国计量科学研究院 Chromium element standard substance in form of medicinal hollow capsule, preparation method thereof, kit combination thereof and method for measuring chromium element content

Also Published As

Publication number Publication date
RU2110258C1 (en) 1998-05-10

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Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20041021

MM4A The patent is invalid due to non-payment of fees

Effective date: 20061021

NF4A Reinstatement of patent

Effective date: 20080220