RU94037954A - 1,2-дигидро-2-оксо-пиридины, способ их получения, фармацевтическая композиция, способ ее получения - Google Patents

1,2-дигидро-2-оксо-пиридины, способ их получения, фармацевтическая композиция, способ ее получения

Info

Publication number
RU94037954A
RU94037954A RU94037954/04A RU94037954A RU94037954A RU 94037954 A RU94037954 A RU 94037954A RU 94037954/04 A RU94037954/04 A RU 94037954/04A RU 94037954 A RU94037954 A RU 94037954A RU 94037954 A RU94037954 A RU 94037954A
Authority
RU
Russia
Prior art keywords
preparation
dihydro
pyridines
oxo
pharmcomposition
Prior art date
Application number
RU94037954/04A
Other languages
English (en)
Inventor
Освальд Матиас
De]
Медерски Вернер
Дорш Дитер
Шеллинг Пьер
Байер Норберт
Минк Клаус-Отто
Луэс Ингеборг
Ch]
Original Assignee
Мерк Патент ГмбХ (DE)
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент ГмбХ (DE), Мерк Патент Гмбх filed Critical Мерк Патент ГмбХ (DE)
Publication of RU94037954A publication Critical patent/RU94037954A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Новые 1,2-дигидро-2-оксо-пиридины формулы 1, приведенной в описании, а также их соли обладают антагонистическими к ангиотензину-П свойствами и могут применяться для лечения гипертензии, альдостеронизма, сердечной недостаточности и повышенного внутриглазного давления, а также нарушений центральной нервной системы.

Claims (1)

  1. Новые 1,2-дигидро-2-оксо-пиридины формулы 1, приведенной в описании, а также их соли обладают антагонистическими к ангиотензину-П свойствами и могут применяться для лечения гипертензии, альдостеронизма, сердечной недостаточности и повышенного внутриглазного давления, а также нарушений центральной нервной системы.
RU94037954/04A 1993-10-22 1994-10-21 1,2-дигидро-2-оксо-пиридины, способ их получения, фармацевтическая композиция, способ ее получения RU94037954A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4336051A DE4336051A1 (de) 1993-10-22 1993-10-22 1,2-Dihydro-2-oxo-pyridine
DEP4336051.3 1993-10-22

Publications (1)

Publication Number Publication Date
RU94037954A true RU94037954A (ru) 1996-10-27

Family

ID=6500753

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94037954/04A RU94037954A (ru) 1993-10-22 1994-10-21 1,2-дигидро-2-оксо-пиридины, способ их получения, фармацевтическая композиция, способ ее получения

Country Status (14)

Country Link
EP (1) EP0657435A3 (ru)
JP (1) JPH07242664A (ru)
KR (1) KR950011409A (ru)
CN (1) CN1106388A (ru)
AU (1) AU7593294A (ru)
CA (1) CA2133939A1 (ru)
CZ (1) CZ258594A3 (ru)
DE (1) DE4336051A1 (ru)
HU (1) HU9403060D0 (ru)
NO (1) NO944024L (ru)
PL (1) PL305514A1 (ru)
RU (1) RU94037954A (ru)
SK (1) SK128594A3 (ru)
ZA (1) ZA948311B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100873D0 (sv) * 2001-03-13 2001-03-13 Astrazeneca Ab Method of treatment
JP6281735B2 (ja) * 2013-03-19 2018-02-21 トーアエイヨー株式会社 急性心不全治療薬の評価方法、及び、急性心不全モデルの作製方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2037630C (en) * 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
CA2051705A1 (en) * 1990-06-19 1991-12-20 Kiyoaki Katano Pyridine derivatives having angiotensin ii antagonism
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
DE4334308A1 (de) * 1993-10-08 1995-04-13 Merck Patent Gmbh 1,2-Dihydro-2-oxo-3-methylsulfonylaminomethyl-pyridine

Also Published As

Publication number Publication date
PL305514A1 (en) 1995-05-02
CN1106388A (zh) 1995-08-09
KR950011409A (ko) 1995-05-15
NO944024D0 (no) 1994-10-21
SK128594A3 (en) 1995-05-10
CA2133939A1 (en) 1995-04-23
AU7593294A (en) 1995-05-11
CZ258594A3 (en) 1995-07-12
DE4336051A1 (de) 1995-04-27
EP0657435A3 (de) 1996-03-06
JPH07242664A (ja) 1995-09-19
HU9403060D0 (en) 1994-12-28
EP0657435A2 (de) 1995-06-14
NO944024L (no) 1995-04-24
ZA948311B (en) 1995-06-14

Similar Documents

Publication Publication Date Title
RU94041198A (ru) Производные имидазопиридазина, способ их получения, содержащая их фармацевтическая композиция, способ ее получения
ATE311849T1 (de) Verwendung von kosmetische und pharmazeutische zubereitungen enthaltend 2-decarboxy-2-phosphino prostaglandinderivate
GEP20033083B (en) Method For Stimulation and Cupping Ventricular Arrhythmia
BR9714363A (pt) Derivados de pirazol substituìdos para o tratamento de doenças circulatórias cardìacas
DE69733826D1 (de) Behandlung von leukocyten durch photopheresis
ATE241378T1 (de) Kombinationen von vasopressin und adrenergischen wirkstoffen zur behandlung des plötzlichen herztods
DE69434431D1 (de) Methoden zur behandlung von muskelerkrankungen und muskelstörungen
ATE211392T1 (de) Verwendung des glialen, neurotrophen faktors (gdnf) zur behandlung von gehörstörungen
NO302574B1 (no) Indolkarbazolimider og deres anvendelse
RU94019981A (ru) Производные имидазопиридина, способ их получения, фармацевтическая композиция и способ их получения
ATE161725T1 (de) Verwendung von phosphatdiestern zur behandlung von erkrankungen der retina
RU94037954A (ru) 1,2-дигидро-2-оксо-пиридины, способ их получения, фармацевтическая композиция, способ ее получения
EA199800526A1 (ru) Производные бензимидазола и их применение для лечения вирусных инфекций
ATE192923T1 (de) Verwendung von boswelliasäure zur behandlung von hirntumoren
RU94039513A (ru) Способ лечения отслойки сетчатки, осложненной субретинальным швартообразованием
DE69621786T2 (de) Aminotetralinderivat zur behandlung von herzkreislauferkrankung
ATE359774T1 (de) Taurinderivate verwendbar in der behandlung von netzhauterkrankungen
ATE264675T1 (de) Verwendung von tosylchloramid(en) zur behandlung von erkrankungen der haut, der schleimhaut, von organen und geweben
IT1276462B1 (it) Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
EA199900006A1 (ru) Препарат и способ для лечения застоной сердечной недостаточности
RU93048867A (ru) Ди-, соответственно, триазиндионы, способ их получения, фармацевтическая композиция, способ ее получения и способ лечения
RU94042022A (ru) Лекарственное средство для лечения ишемии мозга
ATE207353T1 (de) Verwendung von benzydamin zur behandlung von krankheitszuständen, die durch tnf verursacht werden
SU1261662A1 (ru) Способ лечени синдрома передней лестничной мышцы
AU586557B2 (en) 1,4-dihydropyridine derivatives, process for their preparation and medicaments containing these compounds