RU94018525A - Замещенные 2-гидрокси-3[1-(1н-имидазол-4-ил)алкил]-бензолкарбоксимидамиды, способы их получения и фармацевтическая композиция на их основе - Google Patents
Замещенные 2-гидрокси-3[1-(1н-имидазол-4-ил)алкил]-бензолкарбоксимидамиды, способы их получения и фармацевтическая композиция на их основеInfo
- Publication number
- RU94018525A RU94018525A RU94018525/04A RU94018525A RU94018525A RU 94018525 A RU94018525 A RU 94018525A RU 94018525/04 A RU94018525/04 A RU 94018525/04A RU 94018525 A RU94018525 A RU 94018525A RU 94018525 A RU94018525 A RU 94018525A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- imidazol
- hydroxy
- methods
- substituted
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- PXXJHWLDUBFPOL-UHFFFAOYSA-N Benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Изобретение относится к новым замещенным 2-гидрокси-3-[1-( 1H-имидазол-4-ил)-алкил]-бензолкарбоксимидамидам и их солям, к способам их получения и содержащим их глазным композициям. Эти новые соединения отвечают обшей формуле I:
в которой R<Mv>1<D> - водород или С<Mv>1<D>-C<Mv>4<D>-алкил; R<Mv>2<D> - водород, гидроксил, амино-группа или C<Mv>1<D>-C<Mv>4<D>- алкил; R<Mv>3<D> - водород; R<Mv>2<D> и R<Mv>3<D> - -CH<Mv>2<D>-CH<Mv>2<D>. Эти соединения способны снижать внутриглазное давление и могут использоваться при лечении и профилактике глаукомы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939310965A GB9310965D0 (en) | 1993-05-27 | 1993-05-27 | 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides |
| GB9310965.0 | 1993-05-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94018525A true RU94018525A (ru) | 1996-03-20 |
| RU2125557C1 RU2125557C1 (ru) | 1999-01-27 |
Family
ID=10736226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94018525A RU2125557C1 (ru) | 1993-05-27 | 1994-05-25 | Замещенные 2-гидрокси-3-[1-(1h-имидазол-4-ил)-алкил] - бензолкарбоксимидамиды, их оптические изомеры, их рацемические смеси или их нетоксичные, офтальмологически приемлемые соли присоединения кислот. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5385927A (ru) |
| EP (1) | EP0626372B1 (ru) |
| JP (1) | JPH0770082A (ru) |
| AT (1) | ATE198196T1 (ru) |
| AU (1) | AU673422B2 (ru) |
| CA (1) | CA2124289A1 (ru) |
| CZ (1) | CZ287136B6 (ru) |
| DE (1) | DE69426433D1 (ru) |
| FI (1) | FI942390A (ru) |
| GB (1) | GB9310965D0 (ru) |
| HU (1) | HUT67813A (ru) |
| IL (1) | IL109750A (ru) |
| MY (1) | MY111216A (ru) |
| NO (1) | NO303824B1 (ru) |
| NZ (1) | NZ260588A (ru) |
| PL (1) | PL175970B1 (ru) |
| RU (1) | RU2125557C1 (ru) |
| SG (1) | SG42791A1 (ru) |
| SK (1) | SK60394A3 (ru) |
| TW (1) | TW263500B (ru) |
| ZA (1) | ZA943651B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9521680D0 (en) * | 1995-10-23 | 1996-01-03 | Orion Yhtymo Oy | New use of imidazole derivatives |
| US5863929A (en) * | 1996-06-25 | 1999-01-26 | Eli Lilly And Company | Anticoagulant agents |
| US6200967B1 (en) | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
| US7902247B2 (en) * | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| EP2196461A1 (de) | 2008-12-15 | 2010-06-16 | Bayer CropScience AG | 4-Amino-1,2,3-benzoxathiazin-Derivate als Pestizide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
| GB8810067D0 (en) * | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
| FI98815C (fi) * | 1990-11-30 | 1997-08-25 | Santen Oy | Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi |
-
1993
- 1993-05-27 GB GB939310965A patent/GB9310965D0/en active Pending
-
1994
- 1994-05-18 MY MYPI94001268A patent/MY111216A/en unknown
- 1994-05-19 SG SG1995001717A patent/SG42791A1/en unknown
- 1994-05-19 DE DE69426433T patent/DE69426433D1/de not_active Expired - Lifetime
- 1994-05-19 EP EP94870084A patent/EP0626372B1/fr not_active Expired - Lifetime
- 1994-05-19 AT AT94870084T patent/ATE198196T1/de not_active IP Right Cessation
- 1994-05-20 CZ CZ19941247A patent/CZ287136B6/cs not_active IP Right Cessation
- 1994-05-23 PL PL94303566A patent/PL175970B1/pl unknown
- 1994-05-23 SK SK603-94A patent/SK60394A3/sk unknown
- 1994-05-23 TW TW083104641A patent/TW263500B/zh active
- 1994-05-24 IL IL109750A patent/IL109750A/en not_active IP Right Cessation
- 1994-05-24 US US08/248,205 patent/US5385927A/en not_active Expired - Fee Related
- 1994-05-24 FI FI942390A patent/FI942390A/fi unknown
- 1994-05-24 NZ NZ260588A patent/NZ260588A/en unknown
- 1994-05-25 AU AU63303/94A patent/AU673422B2/en not_active Ceased
- 1994-05-25 RU RU94018525A patent/RU2125557C1/ru active
- 1994-05-25 HU HU9401574A patent/HUT67813A/hu unknown
- 1994-05-25 ZA ZA943651A patent/ZA943651B/xx unknown
- 1994-05-25 CA CA002124289A patent/CA2124289A1/en not_active Abandoned
- 1994-05-25 NO NO941932A patent/NO303824B1/no not_active IP Right Cessation
- 1994-05-26 JP JP6112960A patent/JPH0770082A/ja active Pending
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