RU93058655A - Антитела, способ получения клетки, способ изменения функций клеток, способ подавления инфицирования, способ подавления роста клеток, способы диагностики - Google Patents
Антитела, способ получения клетки, способ изменения функций клеток, способ подавления инфицирования, способ подавления роста клеток, способы диагностикиInfo
- Publication number
- RU93058655A RU93058655A RU93058655/14A RU93058655A RU93058655A RU 93058655 A RU93058655 A RU 93058655A RU 93058655/14 A RU93058655/14 A RU 93058655/14A RU 93058655 A RU93058655 A RU 93058655A RU 93058655 A RU93058655 A RU 93058655A
- Authority
- RU
- Russia
- Prior art keywords
- cell
- suppressing
- antibodies
- obtaining
- diagnostic methods
- Prior art date
Links
- 102000004965 antibodies Human genes 0.000 title claims 3
- 108090001123 antibodies Proteins 0.000 title claims 3
- 230000001629 suppression Effects 0.000 title 2
- 230000003915 cell function Effects 0.000 title 1
- 230000010261 cell growth Effects 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 201000009910 diseases by infectious agent Diseases 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 210000000265 Leukocytes Anatomy 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive Effects 0.000 claims 1
- 230000001413 cellular Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Claims (1)
- Изобретение относится к межклеточным адгезионным молекулам (ICAM-3), которые вовлечены в процесс, за счет которого лейкоциты распознают участки (и мигрируют в эти участки) воспалений, а также прикрепляются к клеточному субстрату во время воспаления. Изобретение относится к таким молекулам, скрининг-анализу для идентификации таких молекул и антител, способных связывать такие молекулы. Изобретение включает также терапевтические и диагностические применения адгезионных молекул и антител, которые способны их связывать.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71287991A | 1991-06-11 | 1991-06-11 | |
| US712.879 | 1991-06-11 | ||
| US712,879 | 1991-06-11 | ||
| PCT/US1992/004896 WO1992022323A1 (en) | 1991-06-11 | 1992-06-11 | Intercellular adhesion molecule-3 and its binding ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93058655A true RU93058655A (ru) | 1997-01-27 |
| RU2130782C1 RU2130782C1 (ru) | 1999-05-27 |
Family
ID=24863928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93058655A RU2130782C1 (ru) | 1991-06-11 | 1992-06-11 | Рекомбинантная молекула днк, кодирующая молекулу iсам-3, молекула адгезии iсам-3, антитело, способное связываться с такой молекулой, фармацевтическая композиция |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0590051A4 (ru) |
| JP (1) | JP3288042B2 (ru) |
| KR (2) | KR100291844B1 (ru) |
| CN (1) | CN1188528C (ru) |
| BG (1) | BG61682B1 (ru) |
| BR (1) | BR9206142A (ru) |
| CA (1) | CA2110387A1 (ru) |
| CZ (1) | CZ283478B6 (ru) |
| FI (1) | FI935500A (ru) |
| HU (1) | HU217176B (ru) |
| IE (1) | IE921893A1 (ru) |
| IL (1) | IL102176A (ru) |
| MX (1) | MX9202804A (ru) |
| NO (1) | NO317658B1 (ru) |
| NZ (1) | NZ243114A (ru) |
| RO (1) | RO115415B1 (ru) |
| RU (1) | RU2130782C1 (ru) |
| SK (1) | SK279937B6 (ru) |
| UA (1) | UA27763C2 (ru) |
| WO (1) | WO1992022323A1 (ru) |
| ZA (1) | ZA924276B (ru) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891841A (en) * | 1991-06-11 | 1999-04-06 | The Center For Blood Research, Inc. | Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof |
| US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
| US6153395A (en) * | 1992-01-27 | 2000-11-28 | Icos Corporation | ICAM-related protein |
| WO1999018441A1 (en) * | 1992-01-27 | 1999-04-15 | Icos Corporation | Icam-4 and diagnostic uses thereof |
| US5702917A (en) * | 1992-01-27 | 1997-12-30 | Icos Corporation | Polynucleotides encoding human ICAM-4 |
| US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
| US5989843A (en) * | 1992-01-27 | 1999-11-23 | Icos Corporation | Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein |
| EP0578819A4 (en) * | 1992-01-27 | 1994-10-12 | Icos Corp | Icam-related protein. |
| US6818743B1 (en) | 1992-01-27 | 2004-11-16 | Icos Corporation | I-CAM related protein |
| US5880268A (en) * | 1992-01-27 | 1999-03-09 | Icos Corporation | Modulators of the interaction between ICAM-R and αd /CD18 |
| US6100383A (en) * | 1992-01-27 | 2000-08-08 | Icos Corporation | Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions |
| US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
| CA2132637A1 (en) * | 1993-01-22 | 1994-08-04 | Michael W. Gallatin | Icam-related protein |
| DK0726942T3 (da) * | 1993-11-02 | 2002-04-15 | Innogenetics Nv | Monoklonale antistoffer mod skumceller og deres farmaceutiske og diagnostiske anvendelse |
| US5681699A (en) * | 1994-02-11 | 1997-10-28 | Cedars-Sinai Medical Center | Methods of diagnosing ulcerative colitis and Crohn's disease |
| US6884590B1 (en) | 1994-02-11 | 2005-04-26 | Cedars-Sinai Medical Center | Methods of screening for ulcerative colitis and crohn's disease |
| US20020081294A1 (en) | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
| US5914112A (en) * | 1996-01-23 | 1999-06-22 | Genentech, Inc. | Anti-CD18 antibodies in stroke |
| RU2208230C2 (ru) * | 1997-10-02 | 2003-07-10 | Айкос Корпорейшн | Icam-4 и его диагностическое использование |
| GEP20053477B (en) | 1999-08-13 | 2005-03-25 | Biogen Inc | Cell Adhesion Inhibitors and Pharmaceutical Compositions Containing Them |
| US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
| US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| AU2003278541A1 (en) * | 2002-09-20 | 2004-04-08 | Stichting Katholieke Universiteit | Method of treating rheumatoid arthritis by interfering with expression of dc-sign by macrophages and diagnosis thereof |
| US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
| CA2657621A1 (en) | 2006-07-14 | 2008-01-17 | Aviva Biosciences Corporation | Methods and compositions for detecting rare cells from a biological sample |
| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| WO2010075579A2 (en) | 2008-12-24 | 2010-07-01 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy |
| GB201016864D0 (en) | 2010-10-06 | 2010-11-17 | Univ Aston | Therapeutic methods |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| US10316083B2 (en) | 2013-07-19 | 2019-06-11 | Cedars-Sinai Medical Center | Signature of TL1A (TNFSF15) signaling pathway |
| KR20180127416A (ko) | 2016-03-17 | 2018-11-28 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ245651A (en) * | 1989-03-09 | 1997-06-24 | Blood Res Center | Ligand molecules (e.g. antibodies and fragments) capable of binding to intercellular adhesion molecule-2 (icam-2) and their use |
-
1992
- 1992-06-11 NZ NZ243114A patent/NZ243114A/xx unknown
- 1992-06-11 CZ CS932702A patent/CZ283478B6/cs not_active IP Right Cessation
- 1992-06-11 SK SK1395-93A patent/SK279937B6/sk unknown
- 1992-06-11 JP JP50099993A patent/JP3288042B2/ja not_active Expired - Fee Related
- 1992-06-11 WO PCT/US1992/004896 patent/WO1992022323A1/en not_active Application Discontinuation
- 1992-06-11 RU RU93058655A patent/RU2130782C1/ru not_active IP Right Cessation
- 1992-06-11 ZA ZA924276A patent/ZA924276B/xx unknown
- 1992-06-11 BR BR9206142A patent/BR9206142A/pt not_active Application Discontinuation
- 1992-06-11 KR KR1019930703828A patent/KR100291844B1/ko not_active IP Right Cessation
- 1992-06-11 KR KR1020007000978A patent/KR100333120B1/ko not_active IP Right Cessation
- 1992-06-11 MX MX9202804A patent/MX9202804A/es not_active Application Discontinuation
- 1992-06-11 UA UA93003881A patent/UA27763C2/uk unknown
- 1992-06-11 IL IL10217692A patent/IL102176A/en not_active IP Right Cessation
- 1992-06-11 RO RO93-01672A patent/RO115415B1/ro unknown
- 1992-06-11 EP EP19920914138 patent/EP0590051A4/xx not_active Ceased
- 1992-06-11 CA CA002110387A patent/CA2110387A1/en not_active Abandoned
- 1992-06-11 CN CNB921051263A patent/CN1188528C/zh not_active Expired - Fee Related
- 1992-07-01 IE IE189392A patent/IE921893A1/en not_active Application Discontinuation
-
1993
- 1993-12-08 FI FI935500A patent/FI935500A/fi unknown
- 1993-12-09 NO NO934491A patent/NO317658B1/no not_active IP Right Cessation
- 1993-12-10 HU HU9303529A patent/HU217176B/hu not_active IP Right Cessation
- 1993-12-10 BG BG98287A patent/BG61682B1/bg unknown
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