JPS643129A - Separating agent for optical isomer - Google Patents

Separating agent for optical isomer

Info

Publication number
JPS643129A
JPS643129A JP62157001A JP15700187A JPS643129A JP S643129 A JPS643129 A JP S643129A JP 62157001 A JP62157001 A JP 62157001A JP 15700187 A JP15700187 A JP 15700187A JP S643129 A JPS643129 A JP S643129A
Authority
JP
Japan
Prior art keywords
separating agent
avidin
bonding
carrier
optical isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62157001A
Other languages
Japanese (ja)
Other versions
JPH0819010B2 (en
JPH013129A (en
Inventor
Toshinobu Miwa
Takeshi Miyagawa
Hiroshi Inoue
Masanori Kayano
Yasuo Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP62157001A priority Critical patent/JPH0819010B2/en
Publication of JPS643129A publication Critical patent/JPS643129A/en
Publication of JPH013129A publication Critical patent/JPH013129A/en
Publication of JPH0819010B2 publication Critical patent/JPH0819010B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

PURPOSE:To obtain the titled separating agent consisting of a fixed phase obtained by bonding avidin readily available from egg white to a carrier such as silica gel, cellulose or synthetic polymer. CONSTITUTION:The titled separating agent consisting of a fixed phase obtained by bonding avidin readily available from egg white by precipitation by ammonium sulfate. The separation of optical isomer especially in the field of medicine is made possible by the separating agent. A method for bonding avidin to carrier include e.g. method for bonding avidin using aminopropylsilica gel as a carrier and N,N-disuccinimidylcarbonate as a crosslinking agent or using silica gel as a carrier and 3-gricidoxypropyltrimethoxysilane as a crosslinking agent. The above-mentioned separating agent is mainly used in liquid chromatography.
JP62157001A 1987-06-24 1987-06-24 Separation agent for optical isomers Expired - Lifetime JPH0819010B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62157001A JPH0819010B2 (en) 1987-06-24 1987-06-24 Separation agent for optical isomers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62157001A JPH0819010B2 (en) 1987-06-24 1987-06-24 Separation agent for optical isomers

Publications (3)

Publication Number Publication Date
JPS643129A true JPS643129A (en) 1989-01-06
JPH013129A JPH013129A (en) 1989-01-06
JPH0819010B2 JPH0819010B2 (en) 1996-02-28

Family

ID=15640017

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62157001A Expired - Lifetime JPH0819010B2 (en) 1987-06-24 1987-06-24 Separation agent for optical isomers

Country Status (1)

Country Link
JP (1) JPH0819010B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007104A1 (en) * 1991-10-09 1993-04-15 Eisai Co., Ltd. Separating agent comprising bonded conalbumin
US5276062A (en) * 1989-09-29 1994-01-04 Rohm And Haas Company HPLC avidin monomer affinity resin
US5354461A (en) * 1991-02-20 1994-10-11 Eisai Co., Ltd. Packings combining protein to a support via a spacer
US5480542A (en) * 1991-02-20 1996-01-02 Eisai Co., Ltd. Packings combining protein to a support via a spacer
CN104535683A (en) * 2014-12-25 2015-04-22 广州普星药业有限公司 Method for measuring free ibuprofen in arginine ibuprofen by virtue of high-performance liquid chromatography

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276062A (en) * 1989-09-29 1994-01-04 Rohm And Haas Company HPLC avidin monomer affinity resin
US5354461A (en) * 1991-02-20 1994-10-11 Eisai Co., Ltd. Packings combining protein to a support via a spacer
US5480542A (en) * 1991-02-20 1996-01-02 Eisai Co., Ltd. Packings combining protein to a support via a spacer
WO1993007104A1 (en) * 1991-10-09 1993-04-15 Eisai Co., Ltd. Separating agent comprising bonded conalbumin
US5900144A (en) * 1991-10-09 1999-05-04 Eisai Co., Ltd. Separating agent comprising bonded conalbumin
CN104535683A (en) * 2014-12-25 2015-04-22 广州普星药业有限公司 Method for measuring free ibuprofen in arginine ibuprofen by virtue of high-performance liquid chromatography

Also Published As

Publication number Publication date
JPH0819010B2 (en) 1996-02-28

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