RU93058654A - Способ определения полезности пролекарств, превращающихся печенью, их применение в терапии, пролекарство - Google Patents
Способ определения полезности пролекарств, превращающихся печенью, их применение в терапии, пролекарствоInfo
- Publication number
- RU93058654A RU93058654A RU93058654/14A RU93058654A RU93058654A RU 93058654 A RU93058654 A RU 93058654A RU 93058654/14 A RU93058654/14 A RU 93058654/14A RU 93058654 A RU93058654 A RU 93058654A RU 93058654 A RU93058654 A RU 93058654A
- Authority
- RU
- Russia
- Prior art keywords
- usefulness
- cookies
- therapy
- medicine
- determining
- Prior art date
Links
- 235000014510 cooky Nutrition 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrugs Drugs 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- HPABFFGQPLJKBP-UHFFFAOYSA-N 5-fluoro-1H-pyrimidin-2-one Chemical compound OC1=NC=C(F)C=N1 HPABFFGQPLJKBP-UHFFFAOYSA-N 0.000 claims 1
- 102000016777 Aldehyde oxidases Human genes 0.000 claims 1
- 108091022173 Aldehyde oxidases Proteins 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 231100000486 side effect Toxicity 0.000 claims 1
Claims (1)
- Предложен способ установления полезности пролекарства для лечения заболевания. Пролекарство приемлемо, если оно превращается в клетках печени альдегидоксидазой в активное лекарство или метаболит. Показано, что пролекарства также эффективны при лечении заболеваний, как и сами лекарства, причем оказывают многочисленные благоприятные воздействия и лишены многих побочных эффектов. Предложены также способы лечения раковых заболеваний 5-иод-2-пиримидинондезоксирибозой и 5-фтор-2-пиримидиноном.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US701,462 | 1985-02-14 | ||
US70146291A | 1991-05-15 | 1991-05-15 | |
US82947492A | 1992-02-03 | 1992-02-03 | |
US829,474 | 1992-02-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93058654A true RU93058654A (ru) | 1996-11-10 |
RU2126255C1 RU2126255C1 (ru) | 1999-02-20 |
Family
ID=27106792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93058654A RU2126255C1 (ru) | 1991-05-15 | 1992-05-15 | Способ получения противоопухолевого эффекта у млекопитающих |
Country Status (13)
Country | Link |
---|---|
US (1) | US5728684A (ru) |
EP (1) | EP0586523A4 (ru) |
JP (1) | JPH06507902A (ru) |
KR (1) | KR100245252B1 (ru) |
AU (1) | AU673803B2 (ru) |
BG (1) | BG98217A (ru) |
CA (1) | CA2103050A1 (ru) |
HU (1) | HUT67392A (ru) |
IE (1) | IE921581A1 (ru) |
IL (1) | IL101879A (ru) |
NO (2) | NO306850B1 (ru) |
RU (1) | RU2126255C1 (ru) |
WO (1) | WO1992020816A1 (ru) |
Families Citing this family (39)
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GB9600847D0 (en) | 1996-01-16 | 1996-03-20 | Smithkline Beecham Plc | Pharmaceuticals |
US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
EP1109580A4 (en) * | 1998-09-04 | 2004-05-26 | Viropharma Inc | METHOD FOR TREATING OR PREVENTING VIRAL INFECTIONS AND RELATED DISEASES |
US6818227B1 (en) | 1999-02-08 | 2004-11-16 | Alza Corporation | Liposome composition and method for administration of a radiosensitizer |
ES2250112T3 (es) | 1999-03-08 | 2006-04-16 | Medicure Inc. | Analogos de piridoxal para el tratamiento de trastornos causados por carencia de vitamina b6. |
WO2001003745A2 (en) * | 1999-07-09 | 2001-01-18 | Board Of Regents Of University Of Nebraska | Therapy and diagnosis of colorectal cancer with radiopharmaceuticals |
CA2376029A1 (en) | 1999-07-13 | 2001-01-18 | Medicure Inc. | Use of pyridoxin derivatives for the treatment of diabetes and related complications |
WO2001013900A2 (en) * | 1999-08-24 | 2001-03-01 | Medicure International Inc. | Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds |
ATE293119T1 (de) | 2000-02-29 | 2005-04-15 | Medicure Int Inc | Cardioprotektive phosphonate |
US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
AU784840B2 (en) | 2000-03-28 | 2006-07-06 | Medicure International Inc. | Treatment of cerebrovascular disease |
US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
EP1299358B1 (en) | 2000-07-07 | 2007-06-13 | Medicure International Inc. | Pyridoxine and pyridoxal analogues as cardiovascular therapeutics |
US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
US8207142B2 (en) * | 2001-07-31 | 2012-06-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Inhibitor of DNA methylation |
US7015022B2 (en) * | 2002-06-07 | 2006-03-21 | University Of Medicine & Dentistry Of New Jersey | Mammalian catalase-dependent oxidation processes and methods for stimulating oxidative activities |
US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
AU2005259735A1 (en) * | 2004-07-07 | 2006-01-12 | Medicure International Inc. | Combination therapies employing platelet aggregation drugs |
US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
AU2005304220A1 (en) * | 2004-10-28 | 2006-05-18 | Medicure International Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
KR20080023680A (ko) | 2005-05-10 | 2008-03-14 | 인터뮨, 인크. | 스트레스-활성화 단백질 키나제 시스템을 조절하기 위한피리돈 유도체 |
AU2006317440A1 (en) * | 2005-11-28 | 2007-05-31 | Medicure International Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
MX2010012848A (es) | 2008-06-03 | 2011-03-01 | Intermune Inc | Compuestos y metodos para tratar trastornos inflamatorios y fibroticos. |
JP2012521359A (ja) * | 2009-03-20 | 2012-09-13 | アリオス バイオファーマ インク. | 置換されたヌクレオシドアナログおよびヌクレオチドアナログ |
WO2012040127A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
NZ631601A (en) | 2012-03-21 | 2016-06-24 | Alios Biopharma Inc | Solid forms of a thiophosphoramidate nucleotide prodrug |
NZ630805A (en) | 2012-03-22 | 2016-01-29 | Alios Biopharma Inc | Pharmaceutical combinations comprising a thionucleotide analog |
RU2522548C2 (ru) * | 2012-09-26 | 2014-07-20 | Федеральное государственное бюджетное учреждение науки Институт кристаллографии им. А.В. Шубникова Российской академии наук (ИК РАН) | Ингибитор уридинфосфорилаз |
RU2527457C2 (ru) * | 2012-09-27 | 2014-08-27 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Ингибиторы поли(адф-рибозо)полимеразы-1 человека на основе производных урацила |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
CN106459042B (zh) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
WO2016057699A1 (en) | 2014-10-07 | 2016-04-14 | Kinsella Timothy J | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER WITH 5-IODO-2-PYRIMIDINONE-2'-DEOXYRIBOSE (IPdR) |
US11654157B2 (en) | 2017-01-09 | 2023-05-23 | Shuttle Pharmaceuticals, Inc. | Methods and compositions for cancer therapies that include delivery of halogenated thymidines and thymidine phosphorylase inhibitors in combination with radiation |
WO2018148580A1 (en) * | 2017-02-09 | 2018-08-16 | Perfect Daylight Limited | Methods for autism spectrum disorder pharmacotherapy |
US20220296926A1 (en) | 2019-07-31 | 2022-09-22 | Memorial Sloan Kettering Cancer Center | Perfusion modulated tumor dose sculpting with single dose radiotherapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4895937A (en) * | 1982-01-05 | 1990-01-23 | The Research Foundation Of State University Of New York | 5-ioso-2-pyrimidinone nucleoside |
US4782142A (en) * | 1982-01-05 | 1988-11-01 | The Research Foundation Of State University Of New York | Novel 5-substituted 2-pyrimidinone nucleosides and methods of use |
US4468384A (en) * | 1982-01-05 | 1984-08-28 | The Research Foundation Of State University Of New York | Method for the inhibition of the replication of DNA viruses with 5-substituted 2-pyrimidinone nucleosides |
FI881216A (fi) * | 1987-03-16 | 1988-09-17 | Wellcome Found | Terapeutiska nukleosider. |
US4942226A (en) * | 1988-12-29 | 1990-07-17 | Merck & Co., Inc. | Halogenated pyrimidine nucleosides and their derivatives |
ES2111569T3 (es) * | 1990-07-19 | 1998-03-16 | Wellcome Found | Inactivadores de enzimas. |
GB9020930D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Pharmaceutical combinations |
-
1992
- 1992-05-15 CA CA002103050A patent/CA2103050A1/en not_active Abandoned
- 1992-05-15 WO PCT/US1992/004142 patent/WO1992020816A1/en active Application Filing
- 1992-05-15 US US08/146,164 patent/US5728684A/en not_active Expired - Fee Related
- 1992-05-15 JP JP5500240A patent/JPH06507902A/ja not_active Abandoned
- 1992-05-15 KR KR1019930703451A patent/KR100245252B1/ko not_active IP Right Cessation
- 1992-05-15 EP EP92912221A patent/EP0586523A4/en not_active Withdrawn
- 1992-05-15 IL IL101879A patent/IL101879A/en not_active IP Right Cessation
- 1992-05-15 HU HU9303237A patent/HUT67392A/hu unknown
- 1992-05-15 AU AU19982/92A patent/AU673803B2/en not_active Ceased
- 1992-05-15 RU RU93058654A patent/RU2126255C1/ru active
- 1992-07-01 IE IE158192A patent/IE921581A1/en not_active Application Discontinuation
-
1993
- 1993-11-09 NO NO934059A patent/NO306850B1/no not_active IP Right Cessation
- 1993-11-12 BG BG98217A patent/BG98217A/bg unknown
-
1999
- 1999-05-11 NO NO992273A patent/NO308884B1/no not_active IP Right Cessation
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