RU93058644A - Способ получения бактериальных клеток, споры, продукты метаболизма - Google Patents
Способ получения бактериальных клеток, споры, продукты метаболизмаInfo
- Publication number
- RU93058644A RU93058644A RU93058644/13A RU93058644A RU93058644A RU 93058644 A RU93058644 A RU 93058644A RU 93058644/13 A RU93058644/13 A RU 93058644/13A RU 93058644 A RU93058644 A RU 93058644A RU 93058644 A RU93058644 A RU 93058644A
- Authority
- RU
- Russia
- Prior art keywords
- cells
- disputes
- bacterial cells
- producing bacterial
- metabolism products
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000036740 Metabolism Effects 0.000 title 1
- 230000001580 bacterial Effects 0.000 title 1
- 230000004060 metabolic process Effects 0.000 title 1
- 230000035786 metabolism Effects 0.000 title 1
- 210000004027 cells Anatomy 0.000 claims 5
- 210000004215 spores Anatomy 0.000 claims 3
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- -1 calcium Chemical class 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000001360 synchronised Effects 0.000 claims 1
- 230000002588 toxic Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
Claims (1)
- Предложен способ получения Clostridium, которые продуцируют растворители, ферменты, антибиотики, токсичные белки или споры. Удлинение клеток до критической длины, как минимум втрое превышающей ветегативную, индуцируют с помощью последовательного субкультивирования в контролируемых условиях для синхронизации роста числа клеток и их эффективной массы, а также для получения существенно однородной клеточной популяции. Для стабилизации клеток к синхронизированным клеткам критической длины добавляют как минимум 0,01 М двухвалентных катионов, таких как кальций. Образование спор можно продолжить из рефрактильных зрелых свободных спор, которые можно собирать.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US707,177 | 1991-05-24 | ||
| US07/707,177 US5158887A (en) | 1990-09-09 | 1991-05-24 | Process for massive conversion of clostridia in synchronized cells of elongated length or refractile endospores |
| US707.177 | 1991-05-24 | ||
| PCT/US1991/008487 WO1992020782A1 (en) | 1991-05-24 | 1991-11-13 | Process for massive conversion of clostridia into synchronized cells of critical length or refractile endospores |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93058644A true RU93058644A (ru) | 1996-10-27 |
| RU2091483C1 RU2091483C1 (ru) | 1997-09-27 |
Family
ID=24840664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU9193058644A RU2091483C1 (ru) | 1991-05-24 | 1991-11-13 | Способ получения бактериальных клеток рода clostridium, способных продуцировать споры и продукты метаболизма |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5158887A (ru) |
| EP (1) | EP0587566A4 (ru) |
| JP (1) | JPH04356186A (ru) |
| AU (1) | AU669477B2 (ru) |
| BR (1) | BR9107308A (ru) |
| CA (1) | CA2109808A1 (ru) |
| RU (1) | RU2091483C1 (ru) |
| WO (1) | WO1992020782A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2692266C (en) * | 2007-09-27 | 2019-04-16 | Ls9, Inc. | Reduction of the toxic effect of impurities from raw materials by extractive fermentation |
| JPWO2009116127A1 (ja) * | 2008-03-17 | 2011-07-21 | 尭 辻 | 自然環境から取得した微生物試料から有用微生物株を効率的に取得するためのスクリーニング方法、それに用いる薬剤及びスクリーニングキット |
| CN102905562A (zh) | 2010-05-20 | 2013-01-30 | 艺康美国股份有限公司 | 流变学改性的低发泡液体抗菌组合物及其使用方法 |
| RU2509151C1 (ru) * | 2012-11-09 | 2014-03-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика" | Способ получения спорового материала бактерий рода clostridium |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2054643B (en) * | 1979-07-18 | 1983-05-05 | Rolls Royce | Fermentation process for the manufacture of an organic compound |
| US4292406A (en) * | 1979-09-11 | 1981-09-29 | The United States Of America As Represented By The United States Department Of Energy | Anaerobic thermophilic culture system |
| US4652526A (en) * | 1981-07-29 | 1987-03-24 | The Curators Of The University Of Missouri | Ethanol-producing mutants of Clostridium thermosaccharolyticum |
| US4778760A (en) * | 1984-11-09 | 1988-10-18 | Hitachi, Ltd. | Thermostable α-amylase-producing, thermophilic anaerobic bacteria, thermostable α-amylase and process for producing the same |
-
1991
- 1991-05-24 US US07/707,177 patent/US5158887A/en not_active Expired - Fee Related
- 1991-09-09 JP JP3257013A patent/JPH04356186A/ja active Pending
- 1991-11-13 CA CA002109808A patent/CA2109808A1/en not_active Abandoned
- 1991-11-13 BR BR9107308A patent/BR9107308A/pt not_active IP Right Cessation
- 1991-11-13 WO PCT/US1991/008487 patent/WO1992020782A1/en not_active Application Discontinuation
- 1991-11-13 RU RU9193058644A patent/RU2091483C1/ru active
- 1991-11-13 AU AU12422/92A patent/AU669477B2/en not_active Ceased
-
1992
- 1992-12-04 EP EP19920904655 patent/EP0587566A4/en not_active Withdrawn
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