RU93004491A - PHOTO-TERMINATED DERIVATIVES OF GLYCOSAMINOGLYCANES, STAINED GLYCOSAMINO GLYCANS AND METHODS OF THEIR OBTAINING, MEDICAL USE MATERIAL, APPLICATION, METHOD OF PREVENTION OF CELLULAR CELLULAR AND CELLULAR USE THEREOF - Google Patents

PHOTO-TERMINATED DERIVATIVES OF GLYCOSAMINOGLYCANES, STAINED GLYCOSAMINO GLYCANS AND METHODS OF THEIR OBTAINING, MEDICAL USE MATERIAL, APPLICATION, METHOD OF PREVENTION OF CELLULAR CELLULAR AND CELLULAR USE THEREOF

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Publication number
RU93004491A
RU93004491A RU93004491/04A RU93004491A RU93004491A RU 93004491 A RU93004491 A RU 93004491A RU 93004491/04 A RU93004491/04 A RU 93004491/04A RU 93004491 A RU93004491 A RU 93004491A RU 93004491 A RU93004491 A RU 93004491A
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RU
Russia
Prior art keywords
cellular
gag
photo
derivatives
glycosaminoglycanes
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Application number
RU93004491/04A
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Russian (ru)
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RU2139886C1 (en
Inventor
Мацуда Такехиса
Дж. Могхаддам Миноо
Сакураи Кацукийо
Original Assignee
Сейкагаку когио кабусики кайся
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Priority claimed from JP4355441A external-priority patent/JP2855307B2/en
Application filed by Сейкагаку когио кабусики кайся filed Critical Сейкагаку когио кабусики кайся
Publication of RU93004491A publication Critical patent/RU93004491A/en
Application granted granted Critical
Publication of RU2139886C1 publication Critical patent/RU2139886C1/en

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Claims (1)

Предложены фотоотверждаемые производные гликозаминогликанов (GAG) и сшитые гликозаминогликаны, которые отличаются высокой степенью безопасности и биосовместимости, способ получения таких фотоотверждаемых GAG - производных, легко формируемых в результате отливки с использованием растворителя при желании, причем в результате этого способа можно легко исключить непрореагировавшие вещества, вызывающие вредные воздействия, способ получения сшитых GAG и медицинские материалы, созданные на основе фотоотверждаемых производных GAG или сшитых GAG. Фотоотверждаемые GAG - производные содержат гликозаминогликан и связанное с ним фотореактивное соединение, их можно получить, например, осуществляя взаимодействие гидроксильной или карбоксильной группы гликозаминогликана в реакции этерификации или амидирования соответственно с фотореактивным соединением. Сшитые GAG получают из фотоотверждаемых производных GAG за счет межмолекулярной сшивки связанного с ними фотореактивного соединения.Photo-curable glycosaminoglycan derivatives (GAG) and cross-linked glycosaminoglycans, which have a high degree of safety and biocompatibility, have been proposed, a method for producing such photo-curable GAG derivatives, easily formed by solvent casting, if desired, and as a result of this method, unreacted substances can be easily removed, causing adverse effects, a method for producing crosslinked GAG and medical materials based on photocurable GAG derivatives or crosslinked GAG. Photo-curable GAG - derivatives contain a glycosaminoglycan and its associated photoreactive compound; they can be obtained, for example, by reacting the hydroxyl or carboxyl group of the glycosaminoglycan in the esterification or amidation reaction, respectively, with the photoreactive compound. Crosslinked GAGs are obtained from the photocurable GAG derivatives by intermolecular crosslinking of the associated photoreactive compound.
RU93004491A 1992-02-05 1993-02-03 Photoconsolidated derivative of glycoseaminoglycan, cross- -linked derivative of glycoseaminoglycan and methods of their synthesis, composition for medicinal use, method of prevention of cellular and tissue adhesion RU2139886C1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP4-47744 1992-02-05
JP4774492 1992-02-05
JP4-203209 1992-07-08
JP20320992 1992-07-08
JP4-355441 1992-12-21
JP4355441A JP2855307B2 (en) 1992-02-05 1992-12-21 Photoreactive glycosaminoglycans, cross-linked glycosaminoglycans and methods for producing them

Publications (2)

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RU93004491A true RU93004491A (en) 1996-01-27
RU2139886C1 RU2139886C1 (en) 1999-10-20

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RU93004491A RU2139886C1 (en) 1992-02-05 1993-02-03 Photoconsolidated derivative of glycoseaminoglycan, cross- -linked derivative of glycoseaminoglycan and methods of their synthesis, composition for medicinal use, method of prevention of cellular and tissue adhesion

Country Status (14)

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US (2) US5462976A (en)
EP (1) EP0554898B1 (en)
JP (1) JP2855307B2 (en)
KR (1) KR100293043B1 (en)
CN (1) CN1083455C (en)
AT (1) ATE152736T1 (en)
AU (1) AU670921B2 (en)
CA (1) CA2088831C (en)
DE (1) DE69310396T2 (en)
DK (1) DK0554898T3 (en)
ES (1) ES2102537T3 (en)
HU (1) HU215503B (en)
RU (1) RU2139886C1 (en)
TW (1) TW222644B (en)

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