DE69310396D1 - Photo-curable derivatives of glycosaminoglycan, cross-linked glycosaminoglycans and processes for their production - Google Patents
Photo-curable derivatives of glycosaminoglycan, cross-linked glycosaminoglycans and processes for their productionInfo
- Publication number
- DE69310396D1 DE69310396D1 DE69310396T DE69310396T DE69310396D1 DE 69310396 D1 DE69310396 D1 DE 69310396D1 DE 69310396 T DE69310396 T DE 69310396T DE 69310396 T DE69310396 T DE 69310396T DE 69310396 D1 DE69310396 D1 DE 69310396D1
- Authority
- DE
- Germany
- Prior art keywords
- glycosaminoglycan
- photocurable
- derivatives
- gag
- crosslinked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
Abstract
Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4774492 | 1992-02-05 | ||
JP20320992 | 1992-07-08 | ||
JP4355441A JP2855307B2 (en) | 1992-02-05 | 1992-12-21 | Photoreactive glycosaminoglycans, cross-linked glycosaminoglycans and methods for producing them |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69310396D1 true DE69310396D1 (en) | 1997-06-12 |
DE69310396T2 DE69310396T2 (en) | 1997-10-16 |
Family
ID=27293072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69310396T Expired - Lifetime DE69310396T2 (en) | 1992-02-05 | 1993-02-05 | Photo-curable derivatives of glycosaminoglycan, cross-linked glycosaminoglycans and processes for their production |
Country Status (14)
Country | Link |
---|---|
US (2) | US5462976A (en) |
EP (1) | EP0554898B1 (en) |
JP (1) | JP2855307B2 (en) |
KR (1) | KR100293043B1 (en) |
CN (1) | CN1083455C (en) |
AT (1) | ATE152736T1 (en) |
AU (1) | AU670921B2 (en) |
CA (1) | CA2088831C (en) |
DE (1) | DE69310396T2 (en) |
DK (1) | DK0554898T3 (en) |
ES (1) | ES2102537T3 (en) |
HU (1) | HU215503B (en) |
RU (1) | RU2139886C1 (en) |
TW (1) | TW222644B (en) |
Families Citing this family (123)
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- 1992-12-21 JP JP4355441A patent/JP2855307B2/en not_active Expired - Lifetime
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1993
- 1993-02-03 RU RU93004491A patent/RU2139886C1/en active
- 1993-02-04 HU HU9300297A patent/HU215503B/en unknown
- 1993-02-04 CA CA002088831A patent/CA2088831C/en not_active Expired - Lifetime
- 1993-02-05 AT AT93101838T patent/ATE152736T1/en active
- 1993-02-05 DE DE69310396T patent/DE69310396T2/en not_active Expired - Lifetime
- 1993-02-05 US US08/013,799 patent/US5462976A/en not_active Expired - Lifetime
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- 1993-02-05 KR KR1019930001545A patent/KR100293043B1/en not_active IP Right Cessation
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- 1993-02-05 ES ES93101838T patent/ES2102537T3/en not_active Expired - Lifetime
- 1993-04-08 TW TW082102622A patent/TW222644B/zh not_active IP Right Cessation
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1995
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EP0554898A3 (en) | 1994-01-26 |
HU9300297D0 (en) | 1993-04-28 |
KR930017921A (en) | 1993-09-20 |
ES2102537T3 (en) | 1997-08-01 |
RU2139886C1 (en) | 1999-10-20 |
CA2088831C (en) | 2004-07-06 |
JP2855307B2 (en) | 1999-02-10 |
AU670921B2 (en) | 1996-08-08 |
HU215503B (en) | 1999-01-28 |
CA2088831A1 (en) | 1993-08-06 |
JPH0673102A (en) | 1994-03-15 |
CN1075970A (en) | 1993-09-08 |
ATE152736T1 (en) | 1997-05-15 |
CN1083455C (en) | 2002-04-24 |
HUT71625A (en) | 1996-01-29 |
US5763504A (en) | 1998-06-09 |
EP0554898A2 (en) | 1993-08-11 |
KR100293043B1 (en) | 2001-10-22 |
TW222644B (en) | 1994-04-21 |
DK0554898T3 (en) | 1997-12-01 |
AU3287893A (en) | 1993-08-12 |
DE69310396T2 (en) | 1997-10-16 |
EP0554898B1 (en) | 1997-05-07 |
US5462976A (en) | 1995-10-31 |
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