RU2769317C2 - Способы лечения гриппа - Google Patents
Способы лечения гриппа Download PDFInfo
- Publication number
- RU2769317C2 RU2769317C2 RU2019126746A RU2019126746A RU2769317C2 RU 2769317 C2 RU2769317 C2 RU 2769317C2 RU 2019126746 A RU2019126746 A RU 2019126746A RU 2019126746 A RU2019126746 A RU 2019126746A RU 2769317 C2 RU2769317 C2 RU 2769317C2
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- Prior art keywords
- influenza
- virus
- subject
- infection
- pharmaceutically acceptable
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| TWI740546B (zh) | 2014-10-29 | 2021-09-21 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
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| KR102460968B1 (ko) | 2017-03-14 | 2022-11-01 | 길리애드 사이언시즈, 인코포레이티드 | 고양이 코로나바이러스 감염의 치료 방법 |
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| CA3077489A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| CN118766947A (zh) | 2020-01-27 | 2024-10-15 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| TWI890963B (zh) | 2020-03-12 | 2025-07-21 | 美商基利科學股份有限公司 | 1'-氰基核苷之製備方法 |
| CN115362004A (zh) | 2020-04-06 | 2022-11-18 | 吉利德科学公司 | 1’-氰基取代的碳核苷类似物的吸入制剂 |
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| JP7559223B2 (ja) | 2020-08-24 | 2024-10-01 | ギリアード サイエンシーズ， インコーポレイテッド | リン脂質化合物及びその使用 |
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| WO2023023527A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| WO2023092180A1 (en) * | 2021-11-24 | 2023-06-01 | Biotron Limited | Methods of treating sars-cov-2 infection |
| CA3243944A1 (en) | 2022-03-02 | 2023-09-07 | Gilead Sciences, Inc. | COMPOUNDS AND METHODS OF TREATMENT FOR VIRAL INFECTIONS |
| TW202525810A (zh) | 2022-03-02 | 2025-07-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
| US20230382940A1 (en) | 2022-03-03 | 2023-11-30 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| PE20250419A1 (es) | 2022-03-03 | 2025-02-14 | Gilead Sciences Inc | Compuestos antivirales y metodos de elaboracion y uso de los mismos |
| JP2025519390A (ja) | 2022-06-06 | 2025-06-26 | ギリアード サイエンシーズ， インコーポレイテッド | Ｓａｒｓ－ｃｏｖ－２を含むウイルス感染の治療方法 |
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| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140066487A1 (en) * | 2005-06-24 | 2014-03-06 | Biotron Limited | Antiviral compounds and methods |
| EA022336B1 (ru) * | 2011-04-19 | 2015-12-30 | Ил-Янг Фарм. Ко., Лтд. | Производные фенилизоксазола и способ его получения |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0814737B8 (pt) * | 2007-08-03 | 2021-05-25 | Biotron Ltd | composição para o tratamento de hcv, e, uso de uma composição |
| KR20170063512A (ko) * | 2014-07-07 | 2017-06-08 | 프로필락시스 엘엘씨 | 바이러스 예방 치료 방법 및 사전-노출 예방 키트 |
| CN110870864B (zh) | 2018-08-29 | 2021-09-24 | 复旦大学 | 马来酸卡比沙明在制备抗流感病毒药物中的应用 |
-
2018
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140066487A1 (en) * | 2005-06-24 | 2014-03-06 | Biotron Limited | Antiviral compounds and methods |
| US20160376231A1 (en) * | 2005-06-24 | 2016-12-29 | Biotron Limited | Antiviral compounds and methods |
| EA022336B1 (ru) * | 2011-04-19 | 2015-12-30 | Ил-Янг Фарм. Ко., Лтд. | Производные фенилизоксазола и способ его получения |
Non-Patent Citations (1)
| Title |
|---|
| Jalily P.H. et al. Mechanisms of Action of Novel Influenza A/M2 Viroporin Inhibitors Derived from Hexamethylene Amiloride. Molecular Pharmacology, 2016, 90 (2), pp.80-95. * |
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| RU2019126746A3 (cg-RX-API-DMAC7.html) | 2021-05-28 |
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| JP2020506243A (ja) | 2020-02-27 |
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| BR112019016316A2 (pt) | 2020-03-31 |
| MX387115B (es) | 2025-03-19 |
| CN110325187A (zh) | 2019-10-11 |
| WO2018145148A1 (en) | 2018-08-16 |
| KR102607599B1 (ko) | 2023-11-28 |
| EP3579833A1 (en) | 2019-12-18 |
| SG11201907034PA (en) | 2019-08-27 |
| AU2018218179B2 (en) | 2023-05-04 |
| ES2910136T3 (es) | 2022-05-11 |
| US10918623B2 (en) | 2021-02-16 |
| KR20190112051A (ko) | 2019-10-02 |
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