RU2768027C2 - Генетически модифицированные бактерии, стабильно экспрессирующие ил-10 и инсулин - Google Patents
Генетически модифицированные бактерии, стабильно экспрессирующие ил-10 и инсулин Download PDFInfo
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| EP3897691A4 (en) * | 2018-12-21 | 2022-08-31 | The Regents of the University of California | IL-10 CONTAINING VACCINES AND THEIR USES |
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| WO2003064607A2 (en) * | 2002-01-31 | 2003-08-07 | Symbigene, Inc. | Clinical grade vectors based on natural microflora for use in delivering therapeutic compositions |
| RU2466185C2 (ru) * | 2007-03-28 | 2012-11-10 | Элиментари Хелт Лимитед | ПРОБИОТИЧЕСКИЙ ШТАММ Bifidobacterium longum, ПРОБИОТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЯ ШТАММА Bifidobacterium longum |
| WO2013041673A1 (en) * | 2011-09-23 | 2013-03-28 | Actogenix Nv | Modified gram positive bacteria and uses thereof |
| US9181318B2 (en) * | 2009-03-16 | 2015-11-10 | Jnc Corporation | Method of screening a drug such as insulin secretagogue |
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| WO2004056850A2 (en) * | 2002-12-19 | 2004-07-08 | Vib Vzw | Mutant proteins showing increased secretion |
| US8748126B2 (en) | 2005-11-29 | 2014-06-10 | Actogenix N.V. | Induction of mucosal tolerance to antigens |
| CN101605900B (zh) * | 2007-01-12 | 2014-04-23 | 阿克图杰尼斯公司 | 乳球菌启动子和其用途 |
| EP2125010B1 (en) | 2007-01-25 | 2014-06-04 | Actogenix N.V. | Treatment of immune disease by mucosal delivery of antigens using genetically modified lactobacillus |
| DK2424972T3 (da) | 2009-04-30 | 2013-10-14 | Actogenix Nv | Kryobeskyttende midler til frysetørring af mælkesyrebakterier |
| CA2837634C (en) | 2011-06-01 | 2021-12-14 | Actogenix Nv | Polycistronic expression system for bacteria |
| ES2676707T3 (es) * | 2011-09-23 | 2018-07-24 | Intrexon Actobiotics Nv | Bacterias gram positivas modificadas y usos de las mismas |
| CA3035151A1 (en) * | 2016-09-02 | 2018-03-08 | Intrexon Actobiotics N.V. | Genetically modified bacteria stably expressing il-10 and insulin |
-
2017
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- 2017-09-02 EP EP17784999.9A patent/EP3506932B1/en active Active
- 2017-09-02 JP JP2019512264A patent/JP7016865B2/ja not_active Expired - Fee Related
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- 2017-09-02 RU RU2019104948A patent/RU2768027C2/ru active
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003064607A2 (en) * | 2002-01-31 | 2003-08-07 | Symbigene, Inc. | Clinical grade vectors based on natural microflora for use in delivering therapeutic compositions |
| RU2466185C2 (ru) * | 2007-03-28 | 2012-11-10 | Элиментари Хелт Лимитед | ПРОБИОТИЧЕСКИЙ ШТАММ Bifidobacterium longum, ПРОБИОТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЯ ШТАММА Bifidobacterium longum |
| US9181318B2 (en) * | 2009-03-16 | 2015-11-10 | Jnc Corporation | Method of screening a drug such as insulin secretagogue |
| WO2013041673A1 (en) * | 2011-09-23 | 2013-03-28 | Actogenix Nv | Modified gram positive bacteria and uses thereof |
Non-Patent Citations (5)
| Title |
|---|
| STEIDLER L. ET AL. Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10. Nat Biotechnol. 2003 Jul;21(7):785-9. * |
| TAKIISHI T. ET AL. Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice. J Clin Invest. 2012 May;122(5):1717-25. * |
| база данных GenBank: HL284328.1, Sequence 3 из * |
| Найдено онлайн: https://www.ncbi.nlm.nih.gov/nuccore/HL284328.1/ Дата обращения 21.05.2021. база данных UniProtKB - P01308 (INS_HUMAN), 21.07.1986. Найдено онлайн: https://www.uniprot.org/uniprot/P01308 Дата обращения 21.05.2021. * |
| Найдено онлайн: https://www.ncbi.nlm.nih.gov/nuccore/HL284328.1/ Дата обращения 21.05.2021. база данных UniProtKB - P01308 (INS_HUMAN), 21.07.1986. Найдено онлайн: https://www.uniprot.org/uniprot/P01308 Дата обращения 21.05.2021. STEIDLER L. ET AL. Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10. Nat Biotechnol. 2003 Jul;21(7):785-9. * |
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| CN118813511A (zh) | 2024-10-22 |
| AU2017319707A1 (en) | 2019-03-07 |
| RU2019104948A (ru) | 2020-10-02 |
| JP7016865B2 (ja) | 2022-03-03 |
| US10858663B2 (en) | 2020-12-08 |
| JP2019526262A (ja) | 2019-09-19 |
| CA3035151A1 (en) | 2018-03-08 |
| RU2019104948A3 (enExample) | 2020-12-23 |
| AU2017319707B2 (en) | 2023-11-09 |
| US20210180072A1 (en) | 2021-06-17 |
| US20190292551A1 (en) | 2019-09-26 |
| WO2018042390A1 (en) | 2018-03-08 |
| CN109843320A (zh) | 2019-06-04 |
| JP2024047590A (ja) | 2024-04-05 |
| US11549118B2 (en) | 2023-01-10 |
| EP3506932B1 (en) | 2025-06-25 |
| US12359210B2 (en) | 2025-07-15 |
| US20230348918A1 (en) | 2023-11-02 |
| EP3506932A1 (en) | 2019-07-10 |
| JP2022061035A (ja) | 2022-04-15 |
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