RU2760558C9 - Целевой лекарственный препарат и новые композиции, комбинации на его основе и способы их применения - Google Patents

Целевой лекарственный препарат и новые композиции, комбинации на его основе и способы их применения Download PDF

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RU2760558C9
RU2760558C9 RU2019137004A RU2019137004A RU2760558C9 RU 2760558 C9 RU2760558 C9 RU 2760558C9 RU 2019137004 A RU2019137004 A RU 2019137004A RU 2019137004 A RU2019137004 A RU 2019137004A RU 2760558 C9 RU2760558 C9 RU 2760558C9
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compound
dex
formula
propan
phenoxy
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RU2019137004A
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Russian (ru)
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RU2019137004A3 (https=
RU2019137004A (ru
RU2760558C2 (ru
Inventor
Шринивасарао ВЕПАЧЕДУ
Ханс Й. МЁБИУС
Антон БЕСПАЛОВ
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Эксива Гмбх
Шринивасарао ВЕПАЧЕДУ
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Priority claimed from PCT/US2017/048748 external-priority patent/WO2018039642A1/en
Application filed by Эксива Гмбх, Шринивасарао ВЕПАЧЕДУ filed Critical Эксива Гмбх
Publication of RU2019137004A3 publication Critical patent/RU2019137004A3/ru
Publication of RU2019137004A publication Critical patent/RU2019137004A/ru
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Publication of RU2760558C9 publication Critical patent/RU2760558C9/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
RU2019137004A 2017-05-04 2018-05-03 Целевой лекарственный препарат и новые композиции, комбинации на его основе и способы их применения RU2760558C9 (ru)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201762501696P 2017-05-04 2017-05-04
US62/501,696 2017-05-04
USPCT/US2017/048748 2017-08-25
PCT/US2017/048748 WO2018039642A1 (en) 2016-08-26 2017-08-25 Compositions and methods thereof
TW106129169 2017-08-28
TW106129169A TW201815387A (zh) 2016-08-26 2017-08-28 組成物及其方法
US201862634162P 2018-02-22 2018-02-22
US62/634,162 2018-02-22
US201862636099P 2018-02-27 2018-02-27
US201862635554P 2018-02-27 2018-02-27
US62/636,099 2018-02-27
US62/635,554 2018-02-27
US201862636171P 2018-02-28 2018-02-28
US62/636,171 2018-02-28
PCT/US2018/030978 WO2018204713A1 (en) 2017-05-04 2018-05-03 Targeted drug rescue with novel compositions, combinations, and methods thereof

Publications (4)

Publication Number Publication Date
RU2019137004A3 RU2019137004A3 (https=) 2021-06-04
RU2019137004A RU2019137004A (ru) 2021-06-04
RU2760558C2 RU2760558C2 (ru) 2021-11-29
RU2760558C9 true RU2760558C9 (ru) 2022-02-22

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RU2019137004A RU2760558C9 (ru) 2017-05-04 2018-05-03 Целевой лекарственный препарат и новые композиции, комбинации на его основе и способы их применения

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Country Link
EP (1) EP3618819A4 (https=)
JP (2) JP7514078B2 (https=)
KR (2) KR20200062078A (https=)
CN (1) CN110831584B (https=)
AU (2) AU2018261654A1 (https=)
BR (1) BR112019022902A2 (https=)
CA (2) CA3062452C (https=)
IL (1) IL270326B2 (https=)
MA (1) MA49464A (https=)
RU (1) RU2760558C9 (https=)
TW (1) TWI787260B (https=)
WO (1) WO2018204713A1 (https=)
ZA (1) ZA201908006B (https=)

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* Cited by examiner, † Cited by third party
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MA49464A (fr) * 2017-05-04 2020-04-29 Exciva GmbH Targeted drug rescue avec de nouvelles compositions, associations et procédés correspondants
TW202102219A (zh) * 2019-03-18 2021-01-16 美商艾賓爾製藥公司 使用氘化右旋美沙芬(dextromethorphan)及奎尼丁(quinidine)治療精神分裂症之負面徵候之方法
JP7400818B2 (ja) * 2019-06-06 2023-12-19 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法及び化合物
KR20240096817A (ko) 2020-05-19 2024-06-26 사이빈 아이알엘 리미티드 중수소화된 트립타민 유도체 및 사용 방법
CN116473077B (zh) * 2023-05-08 2025-04-11 广东方中高新材料有限公司 一种n,n配位的镓配合物抗菌剂的合成和应用
CN116473073A (zh) * 2023-05-08 2023-07-25 广东方中高新材料有限公司 一种含镓配合物的吡唑醚菌酯增效悬浮制剂及其制备方法
CN119432479B (zh) * 2023-08-04 2025-10-03 中国石油天然气股份有限公司 柴油机润滑油组合物及其制备方法
CN120987847B (zh) * 2024-11-29 2026-02-17 江苏恩华药业股份有限公司 一种氢溴酸右美沙芬的制备方法

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RU2497819C2 (ru) * 2007-05-21 2013-11-10 Ривайва Фармасьютикалс, Инк. Композиции, синтез и способы применения атипичных нейролептиков на основе хинолина
WO2014011590A2 (en) * 2012-07-12 2014-01-16 Javitt Daniel C Composition and method for treatment of depression and psychosis in humans
WO2014138669A1 (en) * 2013-03-07 2014-09-12 Mindlab LLC Pain medicine combination and uses thereof

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US4950658A (en) * 1988-12-06 1990-08-21 Board Of Trustees Of Southern Illinois Univ. Method of medical treatment of Alzheimer's disease
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US6207674B1 (en) * 1999-12-22 2001-03-27 Richard A. Smith Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants
US6335371B1 (en) * 2000-11-28 2002-01-01 Orion Corporation Method for inducing cognition enhancement
TWI326214B (en) * 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
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RU2497819C2 (ru) * 2007-05-21 2013-11-10 Ривайва Фармасьютикалс, Инк. Композиции, синтез и способы применения атипичных нейролептиков на основе хинолина
WO2014011590A2 (en) * 2012-07-12 2014-01-16 Javitt Daniel C Composition and method for treatment of depression and psychosis in humans
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Also Published As

Publication number Publication date
AU2018261654A1 (en) 2019-11-14
KR102444803B1 (ko) 2022-09-19
KR20210130827A (ko) 2021-11-01
AU2021215274A1 (en) 2021-09-02
CA3062452C (en) 2023-10-24
CN110831584A (zh) 2020-02-21
RU2019137004A3 (https=) 2021-06-04
IL270326B (en) 2022-10-01
TW201842902A (zh) 2018-12-16
IL270326B2 (en) 2023-02-01
KR20200062078A (ko) 2020-06-03
JP7514078B2 (ja) 2024-07-10
CN110831584B (zh) 2023-03-10
WO2018204713A1 (en) 2018-11-08
TWI787260B (zh) 2022-12-21
RU2019137004A (ru) 2021-06-04
CA3138116A1 (en) 2018-11-08
EP3618819A4 (en) 2021-01-20
MA49464A (fr) 2020-04-29
ZA201908006B (en) 2021-04-28
JP2020518617A (ja) 2020-06-25
BR112019022902A2 (pt) 2020-05-19
IL270326A (https=) 2018-05-03
RU2760558C2 (ru) 2021-11-29
JP2023143940A (ja) 2023-10-06
CA3062452A1 (en) 2018-11-08
AU2021215274B2 (en) 2022-11-03
EP3618819A1 (en) 2020-03-11

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