RU2756767C2 - Вакцины, содержащие патогены свиней, для ассоциированного несмешанного применения - Google Patents
Вакцины, содержащие патогены свиней, для ассоциированного несмешанного применения Download PDFInfo
- Publication number
- RU2756767C2 RU2756767C2 RU2019136252A RU2019136252A RU2756767C2 RU 2756767 C2 RU2756767 C2 RU 2756767C2 RU 2019136252 A RU2019136252 A RU 2019136252A RU 2019136252 A RU2019136252 A RU 2019136252A RU 2756767 C2 RU2756767 C2 RU 2756767C2
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- Prior art keywords
- vaccine
- infection
- immunogen
- prrs
- pcv2
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Images
Classifications
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17166590 | 2017-04-13 | ||
| EP17166590.4 | 2017-04-13 | ||
| PCT/EP2018/059389 WO2018189290A1 (en) | 2017-04-13 | 2018-04-12 | Vaccines containing swine pathogens for associated non-mixed use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019136252A3 RU2019136252A3 (https=) | 2021-05-13 |
| RU2019136252A RU2019136252A (ru) | 2021-05-13 |
| RU2756767C2 true RU2756767C2 (ru) | 2021-10-05 |
Family
ID=58547447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019136252A RU2756767C2 (ru) | 2017-04-13 | 2018-04-12 | Вакцины, содержащие патогены свиней, для ассоциированного несмешанного применения |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11311614B2 (https=) |
| EP (2) | EP4335455A3 (https=) |
| JP (2) | JP7665289B2 (https=) |
| KR (1) | KR102724420B1 (https=) |
| CN (1) | CN110446502B (https=) |
| CA (1) | CA3058281A1 (https=) |
| MX (1) | MX390682B (https=) |
| RU (1) | RU2756767C2 (https=) |
| WO (1) | WO2018189290A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11311614B2 (en) * | 2017-04-13 | 2022-04-26 | Intervet Inc. | Vaccines containing swine pathogens for associated non-mixed use |
| CA3176154A1 (en) | 2020-04-20 | 2021-10-28 | Maarten Hendrik Witvliet | A combination of vaccines to prophylactically treat a pig |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2166327C2 (ru) * | 1995-05-15 | 2001-05-10 | Берингер Ингельгейм Корпорейшн | Вакцинная композиция против репродуктивного и респираторного синдрома свиней (prrs) и способ ее получения, способ иммунизации свиней |
| WO2009127684A1 (en) * | 2008-04-18 | 2009-10-22 | Intervet International B.V. | Vaccine for protection against lawsonia intracellularis, mycoplasma hyopneumoniae and porcine circo virus |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004529854A (ja) * | 2000-09-29 | 2004-09-30 | アリゾナ・ボード・オブ・リージエンツ・オン・ビハーフ・オブ・ザ・ユニバーシテイー・オブ・アリゾナ | 増殖性回腸炎のための改善されたワクチン及びその作製と使用の方法 |
| RU2007130801A (ru) | 2005-01-13 | 2009-02-20 | Берингер Ингельхайм Ветмедика Гмбх (De) | Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs) |
| ES2425228T3 (es) | 2005-09-09 | 2013-10-14 | Intervet International B.V. | Vacuna contra el PCV-2 |
| DK3766518T3 (da) | 2005-12-29 | 2026-04-13 | Boehringer Ingelheim Animal Health Usa Inc | Immunogen pcv2-sammensætning til mindskelse af kliniske symptomer hos grise |
| PT2094872T (pt) | 2006-12-15 | 2017-04-27 | Boehringer Ingelheim Vetmedica Inc | Tratamento de porcos seropositivos para o anticorpo anti-pcv2 com antigénio de pcv2 |
| US8728487B2 (en) | 2011-01-20 | 2014-05-20 | Hua Wu | Attenuated live vaccine for prevention of porcine reproductive and respiratory syndrome |
| UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| UA114503C2 (uk) * | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| US9457073B2 (en) | 2012-09-26 | 2016-10-04 | University Of Manitoba | Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity |
| CN105848675A (zh) * | 2013-12-03 | 2016-08-10 | 英特维特国际股份有限公司 | 抗猪圆环病毒2型的疫苗 |
| KR102547168B1 (ko) | 2013-12-03 | 2023-06-22 | 인터벳 인터내셔널 비.브이. | 로소니아 인트라셀룰라리스 및 돼지 써코바이러스 2에 대한 백신 |
| RU2655615C1 (ru) * | 2013-12-03 | 2018-05-29 | Интервет Интернэшнл Б.В. | Вакцина для свиней против prrs и lawsonia intracellularis |
| DK3558425T3 (da) * | 2016-12-22 | 2023-04-24 | Intervet Int Bv | Nålefri injektor |
| US11311614B2 (en) * | 2017-04-13 | 2022-04-26 | Intervet Inc. | Vaccines containing swine pathogens for associated non-mixed use |
-
2018
- 2018-04-12 US US16/604,188 patent/US11311614B2/en active Active
- 2018-04-12 RU RU2019136252A patent/RU2756767C2/ru active
- 2018-04-12 KR KR1020197029516A patent/KR102724420B1/ko active Active
- 2018-04-12 JP JP2019555621A patent/JP7665289B2/ja active Active
- 2018-04-12 WO PCT/EP2018/059389 patent/WO2018189290A1/en not_active Ceased
- 2018-04-12 EP EP23217834.3A patent/EP4335455A3/en active Pending
- 2018-04-12 MX MX2019012220A patent/MX390682B/es unknown
- 2018-04-12 CA CA3058281A patent/CA3058281A1/en active Pending
- 2018-04-12 EP EP18719484.0A patent/EP3609533A1/en not_active Ceased
- 2018-04-12 CN CN201880022778.9A patent/CN110446502B/zh active Active
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2022
- 2022-12-06 JP JP2022194985A patent/JP2023025210A/ja not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2166327C2 (ru) * | 1995-05-15 | 2001-05-10 | Берингер Ингельгейм Корпорейшн | Вакцинная композиция против репродуктивного и респираторного синдрома свиней (prrs) и способ ее получения, способ иммунизации свиней |
| WO2009127684A1 (en) * | 2008-04-18 | 2009-10-22 | Intervet International B.V. | Vaccine for protection against lawsonia intracellularis, mycoplasma hyopneumoniae and porcine circo virus |
Non-Patent Citations (3)
| Title |
|---|
| FLEXFAMILY Mixing Guides", 11 March 2016 (2016-03-11), http://www.bi-vetmedica.com/sites/default/files/dam/internet/ah/vetmedica/com_EN/images/swine/FLEX%20Family%20Mixing%20Guide.pdf XP002773133, весь документ. * |
| FLEXFAMILY Mixing Guides", 11 March 2016 (2016-03-11), http://www.bi-vetmedica.com/sites/default/files/dam/internet/ah/vetmedica/com_EN/images/swine/FLEX%20Family%20Mixing%20Guide.pdf XP002773133, весь документ. WO /2009/ 127684 А, 22.10.2009. * |
| ИНСТРУКЦИЯ по применению вакцины "Порцилис PCV M Hyo" (Вакцина против цирковирусной инфекции и микоплазмоза (энзоотической пневмонии) свиней инактивированная эмульгированная, 30 сентября 2016 г., весь документ) (http://konsulagro.by/assets/konsul/files/instr/%D0%92-%D0%BD%20%D0%9F%D0%BE%D1%80%D1%86%D0%B8%D0%BB%D0%B8%D1%81%20PCV%20m%20hyo.pdf. * |
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| Publication number | Publication date |
|---|---|
| EP3609533A1 (en) | 2020-02-19 |
| CN110446502A (zh) | 2019-11-12 |
| EP4335455A2 (en) | 2024-03-13 |
| US20200046825A1 (en) | 2020-02-13 |
| RU2019136252A3 (https=) | 2021-05-13 |
| RU2019136252A (ru) | 2021-05-13 |
| CN110446502B (zh) | 2024-01-26 |
| KR20190134650A (ko) | 2019-12-04 |
| CA3058281A1 (en) | 2018-10-18 |
| US11311614B2 (en) | 2022-04-26 |
| JP2020513027A (ja) | 2020-04-30 |
| WO2018189290A1 (en) | 2018-10-18 |
| EP4335455A3 (en) | 2024-05-22 |
| MX390682B (es) | 2025-03-21 |
| MX2019012220A (es) | 2019-12-09 |
| JP2023025210A (ja) | 2023-02-21 |
| JP7665289B2 (ja) | 2025-04-21 |
| KR102724420B1 (ko) | 2024-10-30 |
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