RU2751506C2 - Способы обработки текучей среды, содержащей рекомбинантный терапевтический белок, и их применение - Google Patents

Способы обработки текучей среды, содержащей рекомбинантный терапевтический белок, и их применение Download PDF

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RU2751506C2
RU2751506C2 RU2019107142A RU2019107142A RU2751506C2 RU 2751506 C2 RU2751506 C2 RU 2751506C2 RU 2019107142 A RU2019107142 A RU 2019107142A RU 2019107142 A RU2019107142 A RU 2019107142A RU 2751506 C2 RU2751506 C2 RU 2751506C2
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RU2019107142A
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RU2019107142A3 (enExample
RU2019107142A (ru
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Тарл ВЕТТЕР
Майкл КУЛБО
Веена ВАРИКОО
Константин Константинов
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Джензим Корпорейшн
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/06—Submerged-type; Immersion type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
RU2019107142A 2016-08-16 2017-08-15 Способы обработки текучей среды, содержащей рекомбинантный терапевтический белок, и их применение RU2751506C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662375689P 2016-08-16 2016-08-16
US62/375,689 2016-08-16
PCT/US2017/046930 WO2018035116A1 (en) 2016-08-16 2017-08-15 Methods of processing a fluid including a recombinant therapeutic protein and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2021119421A Division RU2021119421A (ru) 2016-08-16 2017-08-15 Способы обработки текучей среды, содержащей рекомбинантный терапевтический белок, и их применение

Publications (3)

Publication Number Publication Date
RU2019107142A RU2019107142A (ru) 2020-09-18
RU2019107142A3 RU2019107142A3 (enExample) 2020-12-17
RU2751506C2 true RU2751506C2 (ru) 2021-07-14

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RU2019107142A RU2751506C2 (ru) 2016-08-16 2017-08-15 Способы обработки текучей среды, содержащей рекомбинантный терапевтический белок, и их применение
RU2021119421A RU2021119421A (ru) 2016-08-16 2017-08-15 Способы обработки текучей среды, содержащей рекомбинантный терапевтический белок, и их применение

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RU2021119421A RU2021119421A (ru) 2016-08-16 2017-08-15 Способы обработки текучей среды, содержащей рекомбинантный терапевтический белок, и их применение

Country Status (13)

Country Link
US (2) US10968252B2 (enExample)
EP (2) EP3950702A1 (enExample)
JP (3) JP7106523B2 (enExample)
KR (1) KR102465761B1 (enExample)
CN (1) CN109843906B (enExample)
AU (1) AU2017313042A1 (enExample)
BR (1) BR112019003013A2 (enExample)
CA (1) CA3034092A1 (enExample)
MX (2) MX2019001859A (enExample)
RU (2) RU2751506C2 (enExample)
SG (1) SG11201901220XA (enExample)
TW (1) TWI767930B (enExample)
WO (1) WO2018035116A1 (enExample)

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KR102465761B1 (ko) 2016-08-16 2022-11-09 젠자임 코포레이션 재조합 치료 단백질을 포함하는 유체의 처리 방법 및 상기 유체의 용도
JP7333779B2 (ja) * 2017-11-16 2023-08-25 クロマコン アーゲー 循環クロマトグラフィー精製プロセスを監視、評価及び制御する方法
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
WO2020185825A1 (en) 2019-03-11 2020-09-17 Genzyme Corporation Tangential viral filtration
AU2020253327B2 (en) * 2019-04-01 2025-04-10 Boehringer Ingelheim International Gmbh Integrated and continuous recombinant protein manufacturing
CN113825840A (zh) 2019-04-03 2021-12-21 建新公司 重组蛋白的连续生产
WO2020258515A1 (zh) * 2019-06-28 2020-12-30 浙江大学 多柱连续流层析设计及分析的方法
KR20220069053A (ko) * 2019-09-23 2022-05-26 젠자임 코포레이션 제품 품질 특성 측정
CA3155216A1 (en) 2019-10-22 2021-04-29 Robert Snow In-line product monitoring in integrated continuous bio-manufacturing
CN116367903B (zh) * 2020-09-14 2024-10-25 恩奎斯特技术公司 生物制剂制造及下游纯化工艺技术
US12458908B2 (en) * 2020-11-30 2025-11-04 PAK Biosolutions Inc. End-to-end continuous purification system
KR20240039642A (ko) * 2022-09-19 2024-03-27 주식회사 녹십자 신규 헤파란-n-설파타아제의 정제 방법
CN119968454A (zh) 2022-09-28 2025-05-09 建新公司 用于生产生物产品的系统和装置及其使用方法
EP4397323A1 (de) * 2023-01-09 2024-07-10 Sartorius Stedim Biotech GmbH Verfahren zur inaktivierung von viren in einem fluid

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US7384549B2 (en) * 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
US20150274773A1 (en) * 2012-10-30 2015-10-01 Hoffmann-La Roche Inc. Purification of polypeptides using dual stage tangential-flow ultrafiltration

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US6365395B1 (en) * 2000-11-03 2002-04-02 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
US20060051347A1 (en) * 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
US7384549B2 (en) * 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
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US11884703B2 (en) 2024-01-30
EP3500589A1 (en) 2019-06-26
CN109843906A (zh) 2019-06-04
US20210171572A1 (en) 2021-06-10
WO2018035116A1 (en) 2018-02-22
EP3500589B1 (en) 2022-05-04
MX2021015165A (es) 2022-01-18
SG11201901220XA (en) 2019-03-28
BR112019003013A2 (pt) 2019-05-14
RU2019107142A3 (enExample) 2020-12-17
US20180051054A1 (en) 2018-02-22
MX2019001859A (es) 2019-08-29
RU2021119421A (ru) 2021-07-13
AU2017313042A1 (en) 2019-04-04
EP3950702A1 (en) 2022-02-09
RU2019107142A (ru) 2020-09-18
US10968252B2 (en) 2021-04-06
TWI767930B (zh) 2022-06-21
KR20190046872A (ko) 2019-05-07
JP2019532916A (ja) 2019-11-14
KR102465761B1 (ko) 2022-11-09
CA3034092A1 (en) 2018-02-22
JP2022110128A (ja) 2022-07-28
CN109843906B (zh) 2023-09-01
JP7106523B2 (ja) 2022-07-26
JP2024079790A (ja) 2024-06-11
TW201811816A (zh) 2018-04-01

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