RU2736406C2 - Устройство для фотодинамической терапии - Google Patents
Устройство для фотодинамической терапии Download PDFInfo
- Publication number
- RU2736406C2 RU2736406C2 RU2018124869A RU2018124869A RU2736406C2 RU 2736406 C2 RU2736406 C2 RU 2736406C2 RU 2018124869 A RU2018124869 A RU 2018124869A RU 2018124869 A RU2018124869 A RU 2018124869A RU 2736406 C2 RU2736406 C2 RU 2736406C2
- Authority
- RU
- Russia
- Prior art keywords
- balloon
- light
- catheter device
- bladder
- distal end
- Prior art date
Links
- 238000002428 photodynamic therapy Methods 0.000 title claims abstract description 67
- 210000003932 urinary bladder Anatomy 0.000 claims abstract description 134
- 238000000034 method Methods 0.000 claims abstract description 35
- 239000012530 fluid Substances 0.000 claims description 98
- 239000003504 photosensitizing agent Substances 0.000 claims description 88
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims description 53
- 239000002243 precursor Substances 0.000 claims description 40
- 239000011159 matrix material Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 238000003780 insertion Methods 0.000 claims description 10
- 230000037431 insertion Effects 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 7
- 230000001678 irradiating effect Effects 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 238000002695 general anesthesia Methods 0.000 abstract description 5
- 238000002690 local anesthesia Methods 0.000 abstract description 3
- 210000000056 organ Anatomy 0.000 description 121
- 229960002749 aminolevulinic acid Drugs 0.000 description 38
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 21
- 239000011780 sodium chloride Substances 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 20
- 238000011282 treatment Methods 0.000 description 20
- 238000013461 design Methods 0.000 description 18
- 206010028980 Neoplasm Diseases 0.000 description 15
- 238000011010 flushing procedure Methods 0.000 description 15
- -1 hematoporphyrins Chemical class 0.000 description 15
- 238000005286 illumination Methods 0.000 description 13
- 239000000463 material Substances 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 239000002245 particle Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 150000002148 esters Chemical class 0.000 description 9
- 239000013307 optical fiber Substances 0.000 description 9
- 239000011257 shell material Substances 0.000 description 9
- 238000009826 distribution Methods 0.000 description 8
- 239000007858 starting material Substances 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 229940005608 hypericin Drugs 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 229950003776 protoporphyrin Drugs 0.000 description 7
- 210000003708 urethra Anatomy 0.000 description 7
- 230000005856 abnormality Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000004907 flux Effects 0.000 description 6
- 238000012549 training Methods 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 239000004816 latex Substances 0.000 description 4
- 229920000126 latex Polymers 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 229940109328 photofrin Drugs 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 210000001215 vagina Anatomy 0.000 description 4
- 206010005003 Bladder cancer Diseases 0.000 description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 description 3
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 230000002262 irrigation Effects 0.000 description 3
- 238000003973 irrigation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000007257 malfunction Effects 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 description 3
- 239000005060 rubber Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 230000001960 triggered effect Effects 0.000 description 3
- 201000005112 urinary bladder cancer Diseases 0.000 description 3
- MHIITNFQDPFSES-UHFFFAOYSA-N 25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1(25),2,4,6,8(27),9,11,13,15,17,19,21,23-tridecaene Chemical class N1C(C=C2C3=CC=CC=C3C(C=C3NC(=C4)C=C3)=N2)=CC=C1C=C1C=CC4=N1 MHIITNFQDPFSES-UHFFFAOYSA-N 0.000 description 2
- KFKRXESVMDBTNQ-UHFFFAOYSA-N 3-[18-(2-carboxylatoethyl)-8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-21,24-diium-2-yl]propanoate Chemical class N1C2=C(C)C(C(C)O)=C1C=C(N1)C(C)=C(C(O)C)C1=CC(C(C)=C1CCC(O)=O)=NC1=CC(C(CCC(O)=O)=C1C)=NC1=C2 KFKRXESVMDBTNQ-UHFFFAOYSA-N 0.000 description 2
- 241000024188 Andala Species 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- 208000009621 actinic keratosis Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 150000004036 bacteriochlorins Chemical class 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 description 2
- 150000004035 chlorins Chemical class 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 230000009826 neoplastic cell growth Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000013021 overheating Methods 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 230000000886 photobiology Effects 0.000 description 2
- 230000002165 photosensitisation Effects 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 150000004032 porphyrins Chemical class 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 150000003458 sulfonic acid derivatives Chemical class 0.000 description 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- ILBBNQMSDGAAPF-UHFFFAOYSA-N 1-(6-hydroxy-6-methylcyclohexa-2,4-dien-1-yl)propan-1-one Chemical compound CCC(=O)C1C=CC=CC1(C)O ILBBNQMSDGAAPF-UHFFFAOYSA-N 0.000 description 1
- UZFPOOOQHWICKY-UHFFFAOYSA-N 3-[13-[1-[1-[8,12-bis(2-carboxyethyl)-17-(1-hydroxyethyl)-3,7,13,18-tetramethyl-21,24-dihydroporphyrin-2-yl]ethoxy]ethyl]-18-(2-carboxyethyl)-8-(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(=C(C)C(C=C4N5)=N3)CCC(O)=O)=N2)C)=C(C)C(C(C)O)=C1C=C5C(C)=C4C(C)OC(C)C1=C(N2)C=C(N3)C(C)=C(C(O)C)C3=CC(C(C)=C3CCC(O)=O)=NC3=CC(C(CCC(O)=O)=C3C)=NC3=CC2=C1C UZFPOOOQHWICKY-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 241000193163 Clostridioides difficile Species 0.000 description 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 description 1
- 206010037128 Pseudomembranous colitis Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000009429 electrical wiring Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000007773 growth pattern Effects 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- LZYXPFZBAZTOCH-UHFFFAOYSA-N hexyl 5-amino-4-oxopentanoate;hydron;chloride Chemical compound Cl.CCCCCCOC(=O)CCC(=O)CN LZYXPFZBAZTOCH-UHFFFAOYSA-N 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 201000004933 in situ carcinoma Diseases 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- YUUAYBAIHCDHHD-UHFFFAOYSA-N methyl 5-aminolevulinate Chemical group COC(=O)CCC(=O)CN YUUAYBAIHCDHHD-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229960004293 porfimer sodium Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000009938 salting Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000002693 spinal anesthesia Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000014794 superficial urinary bladder carcinoma Diseases 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000000287 tissue oxygenation Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/202—Assessing bladder functions, e.g. incontinence assessment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1018—Balloon inflating or inflation-control devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/061—Bladder and/or urethra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Radiation-Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1522398.5A GB201522398D0 (en) | 2015-12-18 | 2015-12-18 | Device for photodynamic therapy |
| GB1522398.5 | 2015-12-18 | ||
| PCT/EP2016/081425 WO2017103105A1 (en) | 2015-12-18 | 2016-12-16 | Device for photodynamic treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018124869A RU2018124869A (ru) | 2020-01-20 |
| RU2018124869A3 RU2018124869A3 (cg-RX-API-DMAC7.html) | 2020-03-10 |
| RU2736406C2 true RU2736406C2 (ru) | 2020-11-16 |
Family
ID=55311234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018124869A RU2736406C2 (ru) | 2015-12-18 | 2016-12-16 | Устройство для фотодинамической терапии |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20180369603A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3389778B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6860571B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102666387B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108778413B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016369404B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018012182B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3008555C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3389778T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2926984T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201522398D0 (cg-RX-API-DMAC7.html) |
| PL (1) | PL3389778T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2736406C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017103105A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6441679B2 (ja) | 2011-12-09 | 2018-12-19 | メタベンション インコーポレイテッド | 肝臓系の治療的な神経調節 |
| WO2013134543A1 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Immune system neuromodulation and associated systems and methods |
| WO2016090175A1 (en) | 2014-12-03 | 2016-06-09 | Metavention, Inc. | Systems and methods for modulating nerves or other tissue |
| US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
| ES2965514T3 (es) * | 2017-06-21 | 2024-04-15 | Photocure Asa | Procedimiento de preparación de una composición farmacéutica líquida y dispositivo para su uso en dicho procedimiento |
| WO2019099036A1 (en) | 2017-11-17 | 2019-05-23 | Convergascent Llc | Devices and systems for intraluminal local drug delivery |
| CN112004459A (zh) * | 2018-02-02 | 2020-11-27 | 大学健康网络 | 用于肿瘤可视化和切除的装置、系统和方法 |
| WO2020037032A1 (en) * | 2018-08-17 | 2020-02-20 | St. Jude Medical, Cardiology Division, Inc. | Optical balloon catheters and methods for mapping and ablation |
| KR20200039066A (ko) | 2018-10-04 | 2020-04-16 | 재단법인 아산사회복지재단 | 광역학 치료 장치 |
| US20220117716A1 (en) * | 2018-12-24 | 2022-04-21 | Innoventions Ltd. | Intravesicular device for controlling urinary incontinence |
| SG11202107275QA (en) | 2019-01-17 | 2021-08-30 | Moleculight Inc | Modular system for multi-modal imaging and analysis |
| US20200230378A1 (en) * | 2019-01-22 | 2020-07-23 | Olympus Corporation | Balloon catheter system and method for optical tumor treatment |
| EP3932479B1 (en) * | 2019-02-25 | 2023-07-26 | Otsuka Electronics Co., Ltd. | Photodynamic therapy device |
| US20220152414A1 (en) * | 2019-03-21 | 2022-05-19 | The General Hospital Corporation | Systems and methods for catheter based light delivery |
| GB201905940D0 (en) * | 2019-04-29 | 2019-06-12 | Intract Pharma Ltd | 5-aminolevulinic acid for the local treatment of inflammatory bowel disease |
| KR102273928B1 (ko) | 2019-05-15 | 2021-07-14 | 연세대학교 산학협력단 | 집속초음파 유도에 의해 광투과 깊이를 확보하는 광 조사 장치 및 초음파의 출력을 피드백 제어하여 광을 조사하는 방법 |
| US12402946B2 (en) | 2019-06-19 | 2025-09-02 | Boston Scientific Scimed, Inc. | Breakdown of laser pulse energy for breakup of vascular calcium |
| US12280223B2 (en) | 2019-06-26 | 2025-04-22 | Boston Scientific Scimed, Inc. | Focusing element for plasma system to disrupt vascular lesions |
| CN110339489B (zh) * | 2019-08-09 | 2020-07-21 | 尚华 | 一种新型的血管光纤导丝 |
| US12274497B2 (en) | 2019-12-18 | 2025-04-15 | Bolt Medical, Inc. | Multiplexer for laser-driven intravascular lithotripsy device |
| EP4096686A4 (en) * | 2020-01-27 | 2024-01-10 | Isola Therapeutics, Inc. | TISSUE DOSAGE FOR LOCAL INTRALUMINAL DRUG ADMINISTRATION |
| US12446961B2 (en) | 2020-02-10 | 2025-10-21 | Bolt Medical, Inc. | System and method for pressure monitoring within a catheter system |
| DE102020000934A1 (de) * | 2020-02-14 | 2021-08-19 | Albert-Ludwigs-Universität Freiburg | Transurethraler Katheter mit antimikrobieller Wirkung |
| CN111388873A (zh) * | 2020-03-26 | 2020-07-10 | 苏州科技城医院 | 一种基于蓝光led的胃腔光疗杀菌装置及方法 |
| CN115397506A (zh) * | 2020-03-30 | 2022-11-25 | 泰尔茂株式会社 | 治疗装置及治疗方法 |
| US11918360B1 (en) * | 2020-04-17 | 2024-03-05 | The Brigham And Women's Hospital, Inc. | Systems and methods for examining hollow organs |
| WO2021216605A1 (en) * | 2020-04-20 | 2021-10-28 | Cern Corp | Vaginal light therapy devices and methods for using them |
| US12295654B2 (en) | 2020-06-03 | 2025-05-13 | Boston Scientific Scimed, Inc. | System and method for maintaining balloon integrity within intravascular lithotripsy device with plasma generator |
| CN112402807B (zh) * | 2020-11-18 | 2021-11-23 | 中国人民解放军总医院 | 一种用于人体腔道及空腔器官内的光动力治疗器械 |
| JP2024504606A (ja) | 2021-01-12 | 2024-02-01 | ボルト メディカル インコーポレイテッド | 弁形成カテーテル・システムのためのバルーン組立体 |
| CN112386810B (zh) * | 2021-01-19 | 2021-04-27 | 武汉亚格光电技术股份有限公司 | 冷却式内腔治疗用光动力治疗头 |
| RU2767264C1 (ru) * | 2021-06-24 | 2022-03-17 | Общество с ограниченной ответственностью "БИОСПЕК" | Способ внутрипротоковой фототераностики холангиоцеллюлярного рака |
| US11839391B2 (en) | 2021-12-14 | 2023-12-12 | Bolt Medical, Inc. | Optical emitter housing assembly for intravascular lithotripsy device |
| EP4223365A1 (en) * | 2022-02-08 | 2023-08-09 | Uvisa Health ApS | A device for transmitting light within a body cavity |
| DE102022201337A1 (de) * | 2022-02-09 | 2023-08-10 | Richard Wolf Gmbh | Bestrahlungsvorrichtung für die photodynamische Therapie |
| IL308772A (en) * | 2023-11-22 | 2025-06-01 | Yeda Res & Dev | Photodynamic therapy of tumor by intra-organ illumination |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5415654A (en) * | 1993-10-05 | 1995-05-16 | S.L.T. Japan Co., Ltd. | Laser balloon catheter apparatus |
| WO2005049131A1 (en) * | 2003-11-14 | 2005-06-02 | Lumerx, Inc. | Phototherapy device and system |
| RU2491917C2 (ru) * | 2006-12-22 | 2013-09-10 | Биофронтера Биосайенс Гмбх | Наноэмульсия |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992004934A1 (en) * | 1990-09-14 | 1992-04-02 | American Medical Systems, Inc. | Combined hyperthermia and dilation catheter |
| CA2215069C (en) | 1995-03-10 | 2006-09-12 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6013053A (en) * | 1996-05-17 | 2000-01-11 | Qlt Photo Therapeutics Inc. | Balloon catheter for photodynamic therapy |
| US6146409A (en) * | 1996-05-20 | 2000-11-14 | Bergein F. Overholt | Therapeutic methods and devices for irradiating columnar environments |
| CA2278698C (en) * | 1997-02-04 | 2007-11-20 | Cook Urological Inc. | Suprapubic drainage catheter |
| US6096030A (en) * | 1997-09-23 | 2000-08-01 | Pharmacyclics, Inc. | Light delivery catheter and PDT treatment method |
| FR2777782B1 (fr) | 1998-04-22 | 2001-05-18 | Alexandre Marti | Solution pour la preparation d'une substance pharmaceutique pour le diagnostic et/ou le traitement de lesions tissulaires |
| GB2370992B (en) | 2000-03-23 | 2002-11-20 | Photo Therapeutics Ltd | Therapeutic light source and method |
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| EP1312353A1 (en) | 2001-11-16 | 2003-05-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for hair removal |
| EP1526888A2 (en) * | 2002-08-05 | 2005-05-04 | Miravant Medical Technologies | Light delivery catheter |
| CA2523777C (en) * | 2003-03-14 | 2016-05-10 | Light Sciences Corporation | Light generating device to intravascular use |
| GB2408209A (en) * | 2003-11-18 | 2005-05-25 | Qinetiq Ltd | Flexible medical light source |
| GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| GB0724279D0 (en) | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
| CA2709274A1 (en) | 2007-12-14 | 2009-06-25 | Photoderma Sa | Novel compounds useful in therapeutic and cosmetic methods |
| US20100016844A1 (en) * | 2008-07-21 | 2010-01-21 | Patel Jr Manoj B | Transilluminating foley catheter to facilitate prostate and bladder surgery |
| GB0823472D0 (en) | 2008-12-23 | 2009-01-28 | Photocure Asa | Product |
| SG176687A1 (en) | 2009-06-11 | 2012-01-30 | Photocure Asa | Solid compositions comprising 5-aminolevulinic acid |
| EP2440199B1 (en) | 2009-06-11 | 2016-04-13 | Photocure ASA | Semi-solid compositions and pharmaceutical products |
| EP2563446A1 (en) * | 2010-04-30 | 2013-03-06 | Abbott Cardiovascular Systems Inc. | Improved balloon catheter exhibiting rapid inflation and deflation |
| WO2011161220A1 (en) | 2010-06-23 | 2011-12-29 | Photocure Asa | Hyperosmotic preparations comprising 5 -amino levulinic acid or derivative as photosensitizing agent |
| WO2012004399A1 (en) | 2010-07-09 | 2012-01-12 | Photocure Asa | Dry compositions and devices containing such dry compositions for use in photodynamic therapy or photodynamic diagnosis |
| US10357661B2 (en) | 2011-09-30 | 2019-07-23 | Percuvision, Llc | Medical device and method for internal healing and antimicrobial purposes |
| NZ629914A (en) | 2012-08-03 | 2017-02-24 | Photocure Asa | New derivatives of 5-aminolevulinic acid and their use as photosensitizing agents |
| US20140067024A1 (en) * | 2012-08-30 | 2014-03-06 | Photocure Asa | Dual panel photodynamic therapy lamp |
| US20160151639A1 (en) * | 2013-07-10 | 2016-06-02 | Oxys Ag | Devices and methods for delivery of therapeutic energy |
| CN203598366U (zh) * | 2013-12-16 | 2014-05-21 | 薛晓英 | 一种前列腺癌放疗使用的直肠内气囊 |
| WO2015160064A1 (ko) * | 2014-04-18 | 2015-10-22 | 부경대학교산학협력단 | 산광형 광섬유를 포함하는 프로브, 그 제조 방법 및 응용 |
| CN203971207U (zh) * | 2014-07-07 | 2014-12-03 | 陆改玲 | 一种激光治疗装置 |
-
2015
- 2015-12-18 GB GBGB1522398.5A patent/GB201522398D0/en not_active Ceased
-
2016
- 2016-12-16 CA CA3008555A patent/CA3008555C/en active Active
- 2016-12-16 DK DK16815830.1T patent/DK3389778T3/da active
- 2016-12-16 WO PCT/EP2016/081425 patent/WO2017103105A1/en not_active Ceased
- 2016-12-16 AU AU2016369404A patent/AU2016369404B2/en active Active
- 2016-12-16 EP EP16815830.1A patent/EP3389778B1/en active Active
- 2016-12-16 BR BR112018012182-7A patent/BR112018012182B1/pt active IP Right Grant
- 2016-12-16 RU RU2018124869A patent/RU2736406C2/ru active
- 2016-12-16 US US16/063,203 patent/US20180369603A1/en not_active Abandoned
- 2016-12-16 PL PL16815830.1T patent/PL3389778T3/pl unknown
- 2016-12-16 ES ES16815830T patent/ES2926984T3/es active Active
- 2016-12-16 CN CN201680079677.6A patent/CN108778413B/zh active Active
- 2016-12-16 JP JP2018532139A patent/JP6860571B2/ja active Active
- 2016-12-16 KR KR1020187020011A patent/KR102666387B1/ko active Active
-
2020
- 2020-05-15 US US16/875,391 patent/US11565123B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5415654A (en) * | 1993-10-05 | 1995-05-16 | S.L.T. Japan Co., Ltd. | Laser balloon catheter apparatus |
| WO2005049131A1 (en) * | 2003-11-14 | 2005-06-02 | Lumerx, Inc. | Phototherapy device and system |
| RU2491917C2 (ru) * | 2006-12-22 | 2013-09-10 | Биофронтера Биосайенс Гмбх | Наноэмульсия |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200276450A1 (en) | 2020-09-03 |
| RU2018124869A3 (cg-RX-API-DMAC7.html) | 2020-03-10 |
| JP2018538077A (ja) | 2018-12-27 |
| US20180369603A1 (en) | 2018-12-27 |
| CN108778413B (zh) | 2020-09-15 |
| ES2926984T3 (es) | 2022-10-31 |
| KR102666387B1 (ko) | 2024-05-14 |
| BR112018012182A2 (pt) | 2018-11-27 |
| WO2017103105A1 (en) | 2017-06-22 |
| RU2018124869A (ru) | 2020-01-20 |
| AU2016369404A1 (en) | 2018-07-12 |
| CA3008555A1 (en) | 2017-06-22 |
| GB201522398D0 (en) | 2016-02-03 |
| CA3008555C (en) | 2024-05-14 |
| PL3389778T3 (pl) | 2022-10-10 |
| KR20180095587A (ko) | 2018-08-27 |
| AU2016369404B2 (en) | 2021-09-30 |
| EP3389778B1 (en) | 2022-08-24 |
| US11565123B2 (en) | 2023-01-31 |
| EP3389778A1 (en) | 2018-10-24 |
| BR112018012182B1 (pt) | 2023-11-28 |
| JP6860571B2 (ja) | 2021-04-14 |
| DK3389778T3 (da) | 2022-09-12 |
| CN108778413A (zh) | 2018-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2736406C2 (ru) | Устройство для фотодинамической терапии | |
| JP5548849B2 (ja) | 光活性化薬物療法のための方法および装置 | |
| Qumseya et al. | Photodynamic therapy for Barrett's esophagus and esophageal carcinoma | |
| JP3648555B2 (ja) | カラム状環境を照射する改良された光線治療用装置 | |
| CN106039580B (zh) | 放射装置、套件和混合物 | |
| WO2014079972A1 (en) | Device for photodynamic treatment | |
| CN105307722B (zh) | 照射设备 | |
| US20080161748A1 (en) | Apparatus and Methods Using Visible Light for Debilitating and/or Killing Microorganisms Within the Body | |
| JP2009535116A (ja) | 光ワンドおよびバルーンカテーテル | |
| AU750633B2 (en) | Improved method for targeted topical treatment of disease | |
| JPH07144026A (ja) | 光免疫療法による癌治療装置 | |
| van Staveren et al. | Whole bladder wall photodynamic therapy using 5-ALA: an experimental study in pigs | |
| Mlkvy et al. | Out-patients based ablative treatment of praecancerous gastrointestinal lesions using ALA/PDT with APC | |
| van Zaane et al. | Monitoring mTHPC-mediated PDT of anal intraepithelial neoplasia III |