RU2725807C2 - Растворимый универсальный усиливающий adcc синтетический слитный ген, пептидная технология и их применение - Google Patents
Растворимый универсальный усиливающий adcc синтетический слитный ген, пептидная технология и их применение Download PDFInfo
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- RU2725807C2 RU2725807C2 RU2017124141A RU2017124141A RU2725807C2 RU 2725807 C2 RU2725807 C2 RU 2725807C2 RU 2017124141 A RU2017124141 A RU 2017124141A RU 2017124141 A RU2017124141 A RU 2017124141A RU 2725807 C2 RU2725807 C2 RU 2725807C2
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- cells
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Transplantation (AREA)
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- Oncology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462089097P | 2014-12-08 | 2014-12-08 | |
| US62/089,097 | 2014-12-08 | ||
| US201562200557P | 2015-08-03 | 2015-08-03 | |
| US62/200,557 | 2015-08-03 | ||
| PCT/US2015/064572 WO2016094456A1 (en) | 2014-12-08 | 2015-12-08 | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017124141A RU2017124141A (ru) | 2019-01-10 |
| RU2017124141A3 RU2017124141A3 (OSRAM) | 2019-06-19 |
| RU2725807C2 true RU2725807C2 (ru) | 2020-07-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2017124141A RU2725807C2 (ru) | 2014-12-08 | 2015-12-08 | Растворимый универсальный усиливающий adcc синтетический слитный ген, пептидная технология и их применение |
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| US (2) | US12247062B2 (OSRAM) |
| EP (1) | EP3230311B1 (OSRAM) |
| JP (2) | JP7095992B2 (OSRAM) |
| KR (1) | KR102654033B1 (OSRAM) |
| CN (1) | CN107108718B (OSRAM) |
| AU (1) | AU2015360642B2 (OSRAM) |
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| NZ (1) | NZ732073A (OSRAM) |
| RU (1) | RU2725807C2 (OSRAM) |
| SG (1) | SG11201704124YA (OSRAM) |
| WO (1) | WO2016094456A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3081576T3 (pl) | 2013-12-12 | 2020-03-31 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Przeciwciało anty pd-1, jego fragment wiążący antygen i ich zastosowanie medyczne |
| NZ732073A (en) | 2014-12-08 | 2019-04-26 | 1Globe Biomedical Co Ltd | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
| JP2021524467A (ja) * | 2018-05-23 | 2021-09-13 | メニスマート セラピューティクス， インコーポレイテッドＭａｎｙｓｍａｒｔ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 二重特異性ｔ細胞誘導体及びその使用 |
| KR20230031981A (ko) | 2019-05-14 | 2023-03-07 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| EP4173640A4 (en) * | 2020-06-30 | 2024-08-14 | GAIA BioMedicine Inc. | METHOD FOR STABILIZING THE BINDING OF AN ANTIBODY ON AN NK CELL AND ASSOCIATED USE |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2161044C2 (ru) * | 1991-03-07 | 2000-12-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ направления (индукции) иммунного ответа, днк, вектор, способ лечения |
| US20070292416A1 (en) * | 2003-06-02 | 2007-12-20 | Alexion Pharmaceuticals, Inc. | De-Immunized Anti-Cd3 Antibody |
| US20120294857A1 (en) * | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
| US20130281677A1 (en) * | 2010-12-22 | 2013-10-24 | Cephalon Australia Pty, Ltd. | Modified antibody with improved half-life |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223426A (en) * | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
| ES2176574T3 (es) * | 1996-09-03 | 2002-12-01 | Gsf Forschungszentrum Umwelt | Utilizacion de anticuerpos bi y triespecificos para la induccion de inmunidad tumoral. |
| KR101063278B1 (ko) * | 1998-08-11 | 2011-09-07 | 바이오겐 아이덱 인크. | Ｂ-세포 림프종을 치료하기 위한 항-ｃｄ２０ 항체를 포함하는 약제 |
| EP1355942B1 (en) * | 2000-12-07 | 2008-08-27 | Eli Lilly And Company | Glp-1 fusion proteins |
| IL158969A0 (en) * | 2001-06-01 | 2004-05-12 | Cornell Res Foundation Inc | Modified antibodies to prostate-specific membrane antigen and uses thereof |
| KR101130181B1 (ko) * | 2003-02-27 | 2012-03-28 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 인플루엔자 바이러스 감염의 치료 및 검출에 유용한 핵산분자, 폴리펩티드, 항체 및 이를 포함하는 조성물 |
| KR20120125634A (ko) * | 2003-10-16 | 2012-11-16 | 마이크로메트 에이지 | 다중특이적 탈면역화된 ｃｄ3-바인더 |
| KR20060131892A (ko) * | 2004-02-16 | 2006-12-20 | 마이크로메트 에이지 | 덜 면역원성인 결합 분자 |
| US20080003225A1 (en) | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| JP2010516769A (ja) * | 2007-01-23 | 2010-05-20 | ザイモジェネティクス， インコーポレイテッド | 炎症を軽減するための可溶性ＦｃγＲＩＡ |
| US8043621B2 (en) * | 2007-05-10 | 2011-10-25 | Ramot At Tel Aviv University Ltd. | Recombinant fusion protein and polynucleotide construct for immunotoxin production |
| KR20150031217A (ko) * | 2011-12-15 | 2015-03-23 | 더 로얄 인스티튜션 포 디 어드밴스먼트 오브 러닝/맥길 유니버시티 | 가용성 igf 수용체 fc 융합 단백질 및 이의 용도 |
| MX353382B (es) * | 2012-03-01 | 2018-01-10 | Amgen Res Munich Gmbh | Moleculas de union polipeptido de larga duracion. |
| NZ732073A (en) | 2014-12-08 | 2019-04-26 | 1Globe Biomedical Co Ltd | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
-
2015
- 2015-12-08 NZ NZ732073A patent/NZ732073A/en not_active IP Right Cessation
- 2015-12-08 WO PCT/US2015/064572 patent/WO2016094456A1/en not_active Ceased
- 2015-12-08 CA CA2968987A patent/CA2968987C/en active Active
- 2015-12-08 EP EP15867381.4A patent/EP3230311B1/en active Active
- 2015-12-08 US US15/532,770 patent/US12247062B2/en active Active
- 2015-12-08 KR KR1020177018958A patent/KR102654033B1/ko active Active
- 2015-12-08 CN CN201580064820.XA patent/CN107108718B/zh active Active
- 2015-12-08 AU AU2015360642A patent/AU2015360642B2/en not_active Ceased
- 2015-12-08 SG SG11201704124YA patent/SG11201704124YA/en unknown
- 2015-12-08 JP JP2017530141A patent/JP7095992B2/ja active Active
- 2015-12-08 RU RU2017124141A patent/RU2725807C2/ru active
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2020
- 2020-11-30 JP JP2020198225A patent/JP2021035994A/ja active Pending
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2022
- 2022-04-12 US US17/719,194 patent/US20220235115A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2161044C2 (ru) * | 1991-03-07 | 2000-12-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ направления (индукции) иммунного ответа, днк, вектор, способ лечения |
| US20070292416A1 (en) * | 2003-06-02 | 2007-12-20 | Alexion Pharmaceuticals, Inc. | De-Immunized Anti-Cd3 Antibody |
| US20120294857A1 (en) * | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
| US20130281677A1 (en) * | 2010-12-22 | 2013-10-24 | Cephalon Australia Pty, Ltd. | Modified antibody with improved half-life |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015360642A1 (en) | 2017-06-08 |
| EP3230311A4 (en) | 2018-05-30 |
| US12247062B2 (en) | 2025-03-11 |
| AU2015360642B2 (en) | 2019-04-04 |
| US20170362299A1 (en) | 2017-12-21 |
| SG11201704124YA (en) | 2017-06-29 |
| WO2016094456A1 (en) | 2016-06-16 |
| US20220235115A1 (en) | 2022-07-28 |
| CN107108718A (zh) | 2017-08-29 |
| NZ732073A (en) | 2019-04-26 |
| JP7095992B2 (ja) | 2022-07-05 |
| CA2968987A1 (en) | 2016-06-16 |
| JP2018502068A (ja) | 2018-01-25 |
| KR102654033B1 (ko) | 2024-04-02 |
| JP2021035994A (ja) | 2021-03-04 |
| RU2017124141A (ru) | 2019-01-10 |
| CN107108718B (zh) | 2022-07-22 |
| EP3230311B1 (en) | 2022-01-26 |
| RU2017124141A3 (OSRAM) | 2019-06-19 |
| CA2968987C (en) | 2022-05-10 |
| KR20170089003A (ko) | 2017-08-02 |
| EP3230311A1 (en) | 2017-10-18 |
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