RU2724338C2 - Фармацевтическая комплексная композиция, включающая амлодипин, лозартан и розувастатин - Google Patents
Фармацевтическая комплексная композиция, включающая амлодипин, лозартан и розувастатин Download PDFInfo
- Publication number
- RU2724338C2 RU2724338C2 RU2018103213A RU2018103213A RU2724338C2 RU 2724338 C2 RU2724338 C2 RU 2724338C2 RU 2018103213 A RU2018103213 A RU 2018103213A RU 2018103213 A RU2018103213 A RU 2018103213A RU 2724338 C2 RU2724338 C2 RU 2724338C2
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- rosuvastatin
- mixture
- losartan
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2015-0093714 | 2015-06-30 | ||
KR20150093714 | 2015-06-30 | ||
PCT/KR2016/006977 WO2017003186A1 (en) | 2015-06-30 | 2016-06-29 | Pharmaceutical complex formulation comprising amlodipine, losartan and rosuvastatin |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2018103213A RU2018103213A (ru) | 2019-07-31 |
RU2018103213A3 RU2018103213A3 (ko) | 2019-12-09 |
RU2724338C2 true RU2724338C2 (ru) | 2020-06-23 |
Family
ID=57608904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2018103213A RU2724338C2 (ru) | 2015-06-30 | 2016-06-29 | Фармацевтическая комплексная композиция, включающая амлодипин, лозартан и розувастатин |
Country Status (6)
Country | Link |
---|---|
KR (2) | KR20170003459A (ko) |
CN (2) | CN108156807A (ko) |
MX (2) | MX2017014311A (ko) |
PH (1) | PH12017501986A1 (ko) |
RU (1) | RU2724338C2 (ko) |
WO (1) | WO2017003186A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019022436A2 (ko) * | 2017-07-27 | 2019-01-31 | 에리슨제약(주) | Nep 저해제 및 베타-차단제를 포함하는 약제학적 조성물 |
KR20190043076A (ko) * | 2017-10-17 | 2019-04-25 | 한미약품 주식회사 | 암로디핀, 로자탄 및 로수바스타틴을 포함하는 당뇨병을 동반한 심혈관계 질환의 예방 또는 치료용 약학 조성물 및 이를 포함하는 복합제제 |
CN108245516B (zh) * | 2017-11-09 | 2019-04-12 | 浙江京新药业股份有限公司 | 一种含瑞舒伐他汀钙的药物组合物及其制备方法 |
CN109464407A (zh) * | 2018-12-27 | 2019-03-15 | 成都恒瑞制药有限公司 | 瑞舒伐他汀钙快速释放制剂及其制备方法 |
KR102500643B1 (ko) * | 2019-04-18 | 2023-02-16 | 한미약품 주식회사 | 에제티미브 및 로사르탄을 포함하는 약제학적 복합제제 |
KR20220026641A (ko) * | 2020-08-25 | 2022-03-07 | 주식회사 대웅제약 | 고혈압 및 고지혈증을 치료 또는 예방하기 위한 단일 제형의 약학 조성물 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050096391A1 (en) * | 2003-10-10 | 2005-05-05 | Per Holm | Compositions comprising fenofibrate and rosuvastatin |
WO2009154810A2 (en) * | 2008-02-25 | 2009-12-23 | Dr. Reddy's Laboratories Ltd. | Delivery systems for multiple active agents |
WO2010085047A2 (en) * | 2009-01-23 | 2010-07-29 | Hanmi Pharm. Co., Ltd. | Solid pharmaceutical composition comprising amlodipine and losartan |
WO2013154390A1 (en) * | 2012-04-13 | 2013-10-17 | Hanmi Pharm. Co., Ltd. | Composite formulation comprising multi-unit spheroidal tablet (must) encapsulated in hard capsule and method for preparing same |
WO2015080433A1 (en) * | 2013-11-29 | 2015-06-04 | Hanmi Pharm. Co., Ltd. | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
FR2834212B1 (fr) * | 2001-12-27 | 2004-07-09 | Besins Int Belgique | Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques |
KR100582347B1 (ko) * | 2004-12-30 | 2006-05-22 | 한미약품 주식회사 | 3-하이드록시-3-메틸글루타릴 조효소 a 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법 |
EP2086519B1 (en) * | 2006-10-30 | 2017-06-21 | HanAll Biopharma Co., Ltd. | Controlled release complex composition comprising angiotensin-ii-receptor blockers and hmg-coa reductase inhibitors |
CN101690816A (zh) * | 2009-08-16 | 2010-04-07 | 王丽燕 | 含钙拮抗剂、aⅱ受体拮抗剂和他汀类药的药物组合物 |
-
2016
- 2016-06-29 WO PCT/KR2016/006977 patent/WO2017003186A1/en active Application Filing
- 2016-06-29 MX MX2017014311A patent/MX2017014311A/es unknown
- 2016-06-29 RU RU2018103213A patent/RU2724338C2/ru active
- 2016-06-29 KR KR1020160081848A patent/KR20170003459A/ko active Application Filing
- 2016-06-29 CN CN201680031203.4A patent/CN108156807A/zh active Pending
- 2016-06-29 CN CN202110171819.4A patent/CN112933093A/zh active Pending
-
2017
- 2017-10-27 PH PH12017501986A patent/PH12017501986A1/en unknown
- 2017-11-08 MX MX2021005210A patent/MX2021005210A/es unknown
-
2018
- 2018-04-25 KR KR1020180047999A patent/KR20180044873A/ko not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050096391A1 (en) * | 2003-10-10 | 2005-05-05 | Per Holm | Compositions comprising fenofibrate and rosuvastatin |
WO2009154810A2 (en) * | 2008-02-25 | 2009-12-23 | Dr. Reddy's Laboratories Ltd. | Delivery systems for multiple active agents |
WO2010085047A2 (en) * | 2009-01-23 | 2010-07-29 | Hanmi Pharm. Co., Ltd. | Solid pharmaceutical composition comprising amlodipine and losartan |
WO2013154390A1 (en) * | 2012-04-13 | 2013-10-17 | Hanmi Pharm. Co., Ltd. | Composite formulation comprising multi-unit spheroidal tablet (must) encapsulated in hard capsule and method for preparing same |
WO2015080433A1 (en) * | 2013-11-29 | 2015-06-04 | Hanmi Pharm. Co., Ltd. | Pharmaceutical combination formulation comprising amlodipine, losartan and rosuvastatin |
Also Published As
Publication number | Publication date |
---|---|
KR20170003459A (ko) | 2017-01-09 |
RU2018103213A (ru) | 2019-07-31 |
MX2021005210A (es) | 2021-06-18 |
PH12017501986A1 (en) | 2018-03-19 |
WO2017003186A1 (en) | 2017-01-05 |
KR20180044873A (ko) | 2018-05-03 |
CN112933093A (zh) | 2021-06-11 |
RU2018103213A3 (ko) | 2019-12-09 |
CN108156807A (zh) | 2018-06-12 |
MX2017014311A (es) | 2018-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2724338C2 (ru) | Фармацевтическая комплексная композиция, включающая амлодипин, лозартан и розувастатин | |
TWI649099B (zh) | 包含氨氯地平(amlodipine)、洛沙坦(losartan)及羅舒伐他汀(rosuvastatin)之藥學組合物配方 | |
JP5658172B2 (ja) | アムロジピン及びロサルタンを含む固形薬剤学的組成物及びその製造方法 | |
US7741374B1 (en) | Methods of use of fenofibric acid | |
JP6068765B2 (ja) | 薬学的複合製剤 | |
KR102246657B1 (ko) | 타다라필 및 탐수로신을 함유하는 약학적 캡슐 복합 제제 | |
TWI714560B (zh) | 包含安洛待平(amlodipine)、洛沙坦(losartan)及氯薩利酮(chlorthalidone)的醫藥複合調配物 | |
WO2013100630A1 (en) | Fixed dose combination formulation comprising losartan, amlodipine and hydrochlorothiazide | |
KR20190045286A (ko) | 로수바스타틴 및 에제티미브를 포함하는 제약 조성물 및 그의 제조 방법 | |
KR102569271B1 (ko) | 에제티미브 및 로수바스타틴을 포함하는 약제학적 복합제제 | |
EA037041B1 (ru) | Пероральные фармацевтические составы для лечения связанных с диабетом макрососудистых и микрососудистых осложнений | |
AU2011339150B2 (en) | Complex formulation comprising lercanidipine hydrochloride and valsartan and method for the preparation thereof | |
RU2674978C2 (ru) | Фармацевтическая композиция N-[5-[2-(3,5-диметоксифенил)этил]-2H-пиразол-3-ил]-4-[(3R,5S)-3,5-диметилпиперазин-1-ил]бензамида | |
WO2019230937A1 (ja) | 溶出性に優れた経口固形製剤 | |
TWI827828B (zh) | 包含依澤替米貝(ezetimibe)及洛沙坦(losartan)之藥學組合製劑 |