RU2721948C2 - Комбинации соединений, модулирующих nmda-рецептор - Google Patents
Комбинации соединений, модулирующих nmda-рецептор Download PDFInfo
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- RU2721948C2 RU2721948C2 RU2016146714A RU2016146714A RU2721948C2 RU 2721948 C2 RU2721948 C2 RU 2721948C2 RU 2016146714 A RU2016146714 A RU 2016146714A RU 2016146714 A RU2016146714 A RU 2016146714A RU 2721948 C2 RU2721948 C2 RU 2721948C2
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- nmda receptor
- receptor antagonist
- glyx
- ketamine
- effective amount
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Psychiatry (AREA)
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- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US61/989,183 | 2014-05-06 | ||
| PCT/US2015/029477 WO2015171770A1 (en) | 2014-05-06 | 2015-05-06 | Combinations of nmdar modulating compounds |
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| AU2015317886A1 (en) | 2014-09-15 | 2017-03-09 | Rugen Holdings (Cayman) Limited | Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists |
| WO2016049048A1 (en) * | 2014-09-22 | 2016-03-31 | Rugen Holdings (Cayman) Limited | Treatment of anxiety disorders and autism spectrum disorders |
| EP3253761A4 (en) | 2015-02-04 | 2018-06-20 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists |
| CN107949379A (zh) * | 2015-05-22 | 2018-04-20 | 维斯塔津治疗公司 | L‑4‑氯代犬尿氨酸的治疗用途 |
| EP3303323B1 (en) | 2015-06-01 | 2020-01-08 | Rugen Holdings (Cayman) Limited | 3,3-difluoropiperidine carbamate heterocyclic compounds as nr2b nmda receptor antagonists |
| MA43001A (fr) * | 2015-10-16 | 2021-04-07 | Impact Biosciences Corp | Cannabidiol et hu-211 pour le traitement d'une lésion cérébrale traumatique |
| KR20180102052A (ko) * | 2015-10-16 | 2018-09-14 | 노오쓰웨스턴 유니버시티 | 조현병, 양극성 장애, 인지 손상 및 주요 우울 장애의 치료를 위한 비전형적 항정신병약과 nmda 조절제의 약제학적 병용 |
| WO2017205666A1 (en) * | 2016-05-25 | 2017-11-30 | National Health Research Institutes | Method and composition for decreasing the psychotomimetic side effect and addictive disorder of ketamine |
| EP3544610A1 (en) | 2016-11-22 | 2019-10-02 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
| CN107550907A (zh) * | 2017-08-29 | 2018-01-09 | 昆明医科大学 | 治疗精神分裂症的药物及验证药物的动物模型构建方法 |
| BR112020011401A2 (pt) * | 2017-12-05 | 2020-11-24 | Naurex Inc. | combinação de moduladores de receptor nmda (rapastinel) para uso em tratamento combinado (distúrbio do sono e do snc) |
| PL3505157T3 (pl) | 2017-12-29 | 2022-04-11 | Celon Pharma S.A. | Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie |
| CN110343050B (zh) | 2018-04-04 | 2021-09-24 | 上海键合医药科技有限公司 | 芳香类化合物及其制备方法和用途 |
| CN109223785A (zh) * | 2018-10-29 | 2019-01-18 | 中国药科大学 | 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用 |
| WO2020146878A1 (en) * | 2019-01-11 | 2020-07-16 | Naurex Inc. | Salt and crystalline forms of rapastinel |
| JP7433331B2 (ja) * | 2019-02-14 | 2024-02-19 | アルジャーノン・ファーマスーティカルズ・インコーポレイテッド | 特発性肺線維症を治療するための組成物及び方法 |
| CN114585364B (zh) | 2019-10-28 | 2025-09-02 | 塞伊尔特克斯公司 | 谷氨酸2b受体拮抗剂和σ受体激动剂作为止咳药的用途 |
| CN113234036B (zh) * | 2021-05-12 | 2023-07-14 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| KR20230056971A (ko) * | 2021-10-21 | 2023-04-28 | 삼육대학교산학협력단 | 신규 케타민 유도체를 포함하는 우울증 예방 또는 치료용 약학적 조성물 |
| CA3267545A1 (en) | 2022-09-14 | 2024-03-21 | Soneira Inc., P.B.C. | IBOGA ALKALOID COMPOSITIONS AND PROCESSING METHODS |
| WO2025065271A1 (en) * | 2023-09-26 | 2025-04-03 | Liangzhu Laboratory | Methods and devices for treating depression |
| WO2025124571A1 (zh) * | 2023-12-14 | 2025-06-19 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| CN119174765A (zh) * | 2024-09-04 | 2024-12-24 | 复旦大学附属中山医院 | Gsdme蛋白的小分子抑制剂在肿瘤及其免疫治疗中的作用 |
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| US20130310323A1 (en) * | 2009-10-05 | 2013-11-21 | Northwestern University | Methods of Treating Depression and Other Related Diseases |
| EA019351B1 (ru) * | 2008-07-03 | 2014-03-31 | ПАНМИРА ФАРМАСЬЮТИКАЛС, ЭлЭлСи | Антагонисты рецепторов простагландина d |
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| US5597809A (en) * | 1994-06-23 | 1997-01-28 | Massachusetts Eye & Ear Infirmary | Treatment of optic neuritis |
| EA010430B1 (ru) * | 2003-05-27 | 2008-08-29 | Форест Лэборэтериз, Инк. | Сочетание антагониста nmda-рецептора и селективного ингибитора обратного захвата серотонина для лечения депрессии и других психических расстройств |
| GB0523998D0 (en) * | 2005-11-25 | 2006-01-04 | Merck Sharp & Dohme | Therapeutic agents |
| US20090275597A1 (en) * | 2008-05-02 | 2009-11-05 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| EP2381941A4 (en) * | 2008-12-29 | 2012-08-01 | Univ Vanderbilt | 3.1.0 BICYCLIC GLYTI INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| US8846765B2 (en) * | 2010-06-15 | 2014-09-30 | Gruenenthal Gmbh | Pharmaceutical combination |
| US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| CN104519878A (zh) * | 2012-03-12 | 2015-04-15 | 詹森药业有限公司 | 用于治疗顽固性或难治性抑郁症的艾氯胺酮 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA019351B1 (ru) * | 2008-07-03 | 2014-03-31 | ПАНМИРА ФАРМАСЬЮТИКАЛС, ЭлЭлСи | Антагонисты рецепторов простагландина d |
| US20130310323A1 (en) * | 2009-10-05 | 2013-11-21 | Northwestern University | Methods of Treating Depression and Other Related Diseases |
Non-Patent Citations (1)
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| ZHANG X L ET AL., "A NMDA RECEPTOR GLYCINE SITE PARTIAL AGONIST, GLYX-13, SIMULTANEOUSLY ENCHANCES LTP AND REDUCES LTD AT SCHAFFER COLLATERAL-CA1 SYNAPSES IN HIPPOCAMPUS", NEUROPHARMACOLOGY, PERGAMON PRESS, VOL. 55, NO. 7, 01.12.1988. * |
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| EP3139943A1 (en) | 2017-03-15 |
| BR112016025910A8 (pt) | 2021-07-13 |
| RU2016146714A3 (OSRAM) | 2018-10-08 |
| EP3139943A4 (en) | 2018-07-18 |
| AU2015256075B2 (en) | 2021-02-25 |
| JP2022159322A (ja) | 2022-10-17 |
| JP2017514871A (ja) | 2017-06-08 |
| CA2947976A1 (en) | 2015-11-12 |
| CN106659762A (zh) | 2017-05-10 |
| MX2016014581A (es) | 2018-02-16 |
| WO2015171770A1 (en) | 2015-11-12 |
| KR20220102662A (ko) | 2022-07-20 |
| KR20170013890A (ko) | 2017-02-07 |
| US20170072005A1 (en) | 2017-03-16 |
| BR112016025910A2 (pt) | 2017-08-15 |
| JP2020138973A (ja) | 2020-09-03 |
| AU2015256075A1 (en) | 2016-11-24 |
| RU2016146714A (ru) | 2018-06-06 |
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