RU2720242C2 - Минерализующие фторсодержащие композиции - Google Patents
Минерализующие фторсодержащие композиции Download PDFInfo
- Publication number
- RU2720242C2 RU2720242C2 RU2017126092A RU2017126092A RU2720242C2 RU 2720242 C2 RU2720242 C2 RU 2720242C2 RU 2017126092 A RU2017126092 A RU 2017126092A RU 2017126092 A RU2017126092 A RU 2017126092A RU 2720242 C2 RU2720242 C2 RU 2720242C2
- Authority
- RU
- Russia
- Prior art keywords
- calcium
- acp
- acfp
- monofluorophosphate
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 127
- 230000001089 mineralizing effect Effects 0.000 title claims description 33
- 229910052731 fluorine Inorganic materials 0.000 title description 3
- 239000011737 fluorine Substances 0.000 title description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title 1
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 claims abstract description 99
- 210000003298 dental enamel Anatomy 0.000 claims abstract description 74
- 238000000034 method Methods 0.000 claims abstract description 73
- 230000006378 damage Effects 0.000 claims abstract description 47
- 208000002925 dental caries Diseases 0.000 claims abstract description 44
- 208000004042 dental fluorosis Diseases 0.000 claims abstract description 27
- 206010016818 Fluorosis Diseases 0.000 claims abstract description 25
- 239000000126 substance Substances 0.000 claims abstract description 23
- 206010044038 Tooth erosion Diseases 0.000 claims abstract description 6
- 108010001441 Phosphopeptides Proteins 0.000 claims description 78
- 239000001506 calcium phosphate Substances 0.000 claims description 54
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 52
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 52
- 235000011010 calcium phosphates Nutrition 0.000 claims description 50
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 42
- 239000005018 casein Substances 0.000 claims description 31
- 235000021240 caseins Nutrition 0.000 claims description 31
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 28
- MFLAROGHONQVRM-UHFFFAOYSA-L calcium;dihydrogen phosphate;fluoride Chemical compound [F-].[Ca+2].OP(O)([O-])=O MFLAROGHONQVRM-UHFFFAOYSA-L 0.000 claims description 25
- 210000000214 mouth Anatomy 0.000 claims description 24
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- 235000015218 chewing gum Nutrition 0.000 claims description 11
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- 239000007788 liquid Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
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- 241001465754 Metazoa Species 0.000 claims description 8
- 239000000551 dentifrice Substances 0.000 claims description 5
- 239000006072 paste Substances 0.000 claims description 5
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- 239000002966 varnish Substances 0.000 claims description 4
- 239000003479 dental cement Substances 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 235000013365 dairy product Nutrition 0.000 claims description 2
- 230000002262 irrigation Effects 0.000 claims 1
- 238000003973 irrigation Methods 0.000 claims 1
- 230000033558 biomineral tissue development Effects 0.000 abstract description 15
- 208000036595 non-bacterial tooth erosion Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract 1
- 239000011575 calcium Substances 0.000 description 87
- -1 glycerophosphoric acid compound Chemical class 0.000 description 71
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 67
- 229910052791 calcium Inorganic materials 0.000 description 67
- 229940091249 fluoride supplement Drugs 0.000 description 67
- 150000001875 compounds Chemical class 0.000 description 60
- 239000000243 solution Substances 0.000 description 51
- 230000003902 lesion Effects 0.000 description 41
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 38
- 108010076119 Caseins Proteins 0.000 description 33
- 102000011632 Caseins Human genes 0.000 description 33
- 239000000463 material Substances 0.000 description 33
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 33
- 238000011282 treatment Methods 0.000 description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 28
- 229940074371 monofluorophosphate Drugs 0.000 description 27
- 235000021317 phosphate Nutrition 0.000 description 27
- 239000010452 phosphate Substances 0.000 description 26
- 229910019142 PO4 Inorganic materials 0.000 description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- 230000003628 erosive effect Effects 0.000 description 21
- 229910001868 water Inorganic materials 0.000 description 21
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 20
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- 239000000047 product Substances 0.000 description 20
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- 239000002253 acid Substances 0.000 description 16
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- 239000011775 sodium fluoride Substances 0.000 description 16
- 235000013024 sodium fluoride Nutrition 0.000 description 16
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- 239000003795 chemical substances by application Substances 0.000 description 14
- 150000002500 ions Chemical class 0.000 description 14
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- 238000002360 preparation method Methods 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 11
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- 230000007935 neutral effect Effects 0.000 description 10
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- 241000519995 Stachys sylvatica Species 0.000 description 8
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- 235000001014 amino acid Nutrition 0.000 description 8
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- 239000000706 filtrate Substances 0.000 description 8
- 238000011065 in-situ storage Methods 0.000 description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 description 8
- 235000010755 mineral Nutrition 0.000 description 8
- 239000011707 mineral Substances 0.000 description 8
- 210000003296 saliva Anatomy 0.000 description 8
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 7
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 7
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 239000002324 mouth wash Substances 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 6
- 206010020751 Hypersensitivity Diseases 0.000 description 6
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- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 6
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
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- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 5
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 5
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
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- 238000004448 titration Methods 0.000 description 4
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014905281 | 2014-12-24 | ||
| AU2014905281A AU2014905281A0 (en) | 2014-12-24 | Mineralization fluoride compositions | |
| PCT/AU2015/050843 WO2016101041A1 (en) | 2014-12-24 | 2015-12-24 | Mineralization fluoride compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017126092A RU2017126092A (ru) | 2019-01-25 |
| RU2017126092A3 RU2017126092A3 (enExample) | 2019-07-24 |
| RU2720242C2 true RU2720242C2 (ru) | 2020-04-28 |
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| RU2017126092A RU2720242C2 (ru) | 2014-12-24 | 2015-12-24 | Минерализующие фторсодержащие композиции |
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| US (1) | US20180008518A1 (enExample) |
| EP (1) | EP3237068A4 (enExample) |
| JP (1) | JP2018502099A (enExample) |
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| CN (1) | CN107427700A (enExample) |
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| BR (1) | BR112017013503A2 (enExample) |
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| MX (1) | MX2017008535A (enExample) |
| RU (1) | RU2720242C2 (enExample) |
| SG (1) | SG11201705170UA (enExample) |
| WO (1) | WO2016101041A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007214265B2 (en) | 2006-02-09 | 2012-06-14 | The University Of Melbourne | Fluoride composition and methods for dental mineralization |
| PL3024428T3 (pl) | 2013-07-23 | 2021-07-05 | The University Of Melbourne | Kompozycje i sposoby mineralizacji zębów |
| RU2716134C2 (ru) | 2013-12-24 | 2020-03-06 | Де Юниверсити Оф Мельбурн | Стабилизированные композиции на основе олова (II) |
| US12109284B2 (en) * | 2016-11-08 | 2024-10-08 | Dentherapy Ltd | Compositions comprising fluoride and calcium and method for preparing them |
| KR102862249B1 (ko) | 2017-03-14 | 2025-09-19 | 더 유니버시티 오브 멜버른 | 치은염을 위한 치료 |
| EA201991935A1 (ru) * | 2017-03-14 | 2020-02-14 | Де Юниверсити Оф Мельбурн | Комплексы для лечения чувствительности |
| CN111615378A (zh) * | 2018-01-17 | 2020-09-01 | 宝洁公司 | 用于提高釉质硬度和抵抗力的方法和组合物 |
| IT201800005426A1 (it) * | 2018-05-16 | 2019-11-16 | Prodotto di confetteria contenente polifosfati | |
| CN108379211A (zh) * | 2018-05-24 | 2018-08-10 | 长沙小如信息科技有限公司 | 一种牙齿护理液及其制备方法 |
| CN108524290A (zh) * | 2018-06-28 | 2018-09-14 | 吉林省登泰克牙科材料有限公司 | 牙科预防龋齿组合物及其制备方法 |
| JP2022524856A (ja) * | 2019-03-13 | 2022-05-10 | ザ ユニバーシティー オブ メルボルン | 低石灰化病変の隠蔽 |
| CA3133097A1 (en) | 2019-03-13 | 2020-09-17 | The University Of Melbourne | Compositions and methods for promoting mineralization |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998040406A1 (en) * | 1997-03-13 | 1998-09-17 | The University Of Melbourne | Calcium phosphopeptide complexes |
| US6036944A (en) * | 1995-08-08 | 2000-03-14 | Enamelon, Inc. | Processes for the remineralization and mineralization of teeth |
| EA011125B1 (ru) * | 2005-11-25 | 2008-12-30 | Общество С Ограниченной Ответственностью "Вдс" | Лечебно-профилактический состав для ухода за полостью рта |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3864471A (en) * | 1968-12-20 | 1975-02-04 | Colgate Palmolive Co | Stable dentifrices containing a monofluorophosphate, an insoluble metaphosphate, and calcium carbonate |
| US3966901A (en) * | 1970-12-29 | 1976-06-29 | Colgate-Palmolive Company | Dentifrice preparation |
| US4588763A (en) * | 1978-06-01 | 1986-05-13 | Braennstroem Martin | Ethyl acetate as solvent in cavity liners |
| AU2002320959A1 (en) * | 2002-07-02 | 2004-01-23 | Gumlink As | Compressed chewing gum tablet ii |
| JP3853785B2 (ja) * | 2002-12-27 | 2006-12-06 | 花王株式会社 | 口腔用組成物 |
| CN1320879C (zh) * | 2002-12-27 | 2007-06-13 | 花王株式会社 | 口腔制剂体系 |
| US8591867B2 (en) * | 2002-12-27 | 2013-11-26 | Kao Corporation | Oral preparation system |
| WO2006056013A1 (en) * | 2004-11-25 | 2006-06-01 | The University Of Melbourne | Stabilized calcium phosphate complexes |
| PL1901702T3 (pl) * | 2005-06-24 | 2015-07-31 | Univ Melbourne | Kompleksy jonowe |
| AU2007214265B2 (en) * | 2006-02-09 | 2012-06-14 | The University Of Melbourne | Fluoride composition and methods for dental mineralization |
| WO2010134904A1 (en) * | 2009-05-18 | 2010-11-25 | Colgate-Palmolive Company | Oral compositions containing polyguanidinium compounds and methods of manufacture and use thereof |
| CN102821768A (zh) * | 2010-02-12 | 2012-12-12 | 斯欧考普控股公司 | 提高牙齿的机械抗性的方法和组合物 |
| GB201202341D0 (en) * | 2012-02-10 | 2012-03-28 | Periproducts Ltd | Multicomponent oral care compostion |
| JP2013163656A (ja) * | 2012-02-10 | 2013-08-22 | Gc Corp | 歯磨剤 |
-
2015
- 2015-12-24 RU RU2017126092A patent/RU2720242C2/ru not_active IP Right Cessation
- 2015-12-24 MX MX2017008535A patent/MX2017008535A/es unknown
- 2015-12-24 WO PCT/AU2015/050843 patent/WO2016101041A1/en not_active Ceased
- 2015-12-24 JP JP2017534315A patent/JP2018502099A/ja active Pending
- 2015-12-24 US US15/538,836 patent/US20180008518A1/en not_active Abandoned
- 2015-12-24 KR KR1020177020272A patent/KR20170100580A/ko not_active Withdrawn
- 2015-12-24 CA CA2972105A patent/CA2972105A1/en not_active Abandoned
- 2015-12-24 AU AU2015372368A patent/AU2015372368B2/en not_active Ceased
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- 2015-12-24 EP EP15871364.4A patent/EP3237068A4/en not_active Withdrawn
- 2015-12-24 SG SG11201705170UA patent/SG11201705170UA/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6036944A (en) * | 1995-08-08 | 2000-03-14 | Enamelon, Inc. | Processes for the remineralization and mineralization of teeth |
| WO1998040406A1 (en) * | 1997-03-13 | 1998-09-17 | The University Of Melbourne | Calcium phosphopeptide complexes |
| EA011125B1 (ru) * | 2005-11-25 | 2008-12-30 | Общество С Ограниченной Ответственностью "Вдс" | Лечебно-профилактический состав для ухода за полостью рта |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016101041A9 (en) | 2016-07-28 |
| CN107427700A (zh) | 2017-12-01 |
| US20180008518A1 (en) | 2018-01-11 |
| BR112017013503A2 (pt) | 2018-03-06 |
| KR20170100580A (ko) | 2017-09-04 |
| AU2015372368A1 (en) | 2017-07-06 |
| AU2015372368B2 (en) | 2019-11-21 |
| RU2017126092A (ru) | 2019-01-25 |
| SG11201705170UA (en) | 2017-07-28 |
| JP2018502099A (ja) | 2018-01-25 |
| WO2016101041A1 (en) | 2016-06-30 |
| EP3237068A4 (en) | 2018-09-12 |
| EP3237068A1 (en) | 2017-11-01 |
| CA2972105A1 (en) | 2016-06-30 |
| RU2017126092A3 (enExample) | 2019-07-24 |
| MX2017008535A (es) | 2018-03-23 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20201225 |