RU2717537C1 - Dietary supplement - Google Patents

Abstract

FIELD: biotechnology; food industry.

SUBSTANCE: invention relates to biotechnology and food industry, specifically to a dietary supplement. Dietary supplement is presented in the form of capsules weighing 600 mg and contains a composition of active ingredients - dry peach leaf extract, dry sea-buckthorn extract, dry red bilberry leaves extract, ascorbic acid, 50 % tocopherol acetate, beta-carotene, as well as auxiliary substances - talc, magnesium and/or calcium stearate, silicon dioxide, lactose and capsule components - gelatine, glycerine, copper complex of chlorophyllin, dye - blue shining 85 % at certain ratio of components.

EFFECT: invention allows to produce a dietary supplement having immunomodulating, hypocholesteremic and anticancer properties.

1 cl, 2 ex

Description

The invention relates to biotechnology and the food industry, namely to a biologically active supplement with immunomodulatory, hypocholesterolemic and antitumor properties and which allows to reduce the cost of treating cardiovascular and oncological diseases in the population.

Known biologically active food supplement (RU, patent 2370151 publ. 20.10.2009) which includes plant materials, including calendula, dandelion, peppermint, licorice in the form of infusions (decoctions). The raw materials are individually extracted with honey in a ratio of 1: 5, pumpkin seeds germinated in serum, chickpea seeds, and milk thistle seeds are each individually extracted with honey in a ratio of 1: 2, then the honey extracts are mixed with lactulose, in which succinic acid is previously dissolved from calculation per 100 kg of dietary supplement for 5.0 kg of honey extracts of calendula, dandelion, peppermint, licorice, 10.0 kg of honey extracts of germinated pumpkin seeds, chickpeas, milk thistle, 49.7 kg of lactulose concentrate, 0.3 kg of succinic acid. The disadvantages of the known biologically active food additives are:

- the use of honey extracts is contraindicated for persons with liver diseases, type II diabetes mellitus, obesity, gastric and duodenal ulcer, exacerbation of urolithiasis and cholelithiasis, colitis, pancreatitis, acute rheumatism.

- the increase in the cost of biologically active food additives due to the use of honey as a valuable beekeeping product.

Known biologically active additive (RU, patent 2259147 publ. August 27, 2005), characterized in that it contains the ingredients in the following ratio in mg / l of the mother liquor of sodium humate: total protein - 800.5; total lipids - 5004; potassium - 12.0; sodium - 500.0; calcium - 59.5; iron - 12.5; copper - 0.08; zinc - 0.19; cobalt - 0.02; cadmium - 0.008; manganese - 0.43; ammonium nitrogen - 20.7; nitrates - 0.02; total phosphorus - 16.0; vitamin C - 16.75; triglycerides - 100.59; amylase - 1200-1300; sodium humate - 4800; humic acids - 3600; iodine - 0.12; lysine - 20.0; histidine - 10.0; aspartic acid - 10.0; threonine - 10.0; series - 5.0; glutamic acid - 20.0; proline - 10.0; leucine - 10.0; glycine - 2.0; valine - 3.0; methionine - 0.1; isoleucine - 4.0; tyrosine - 10.0; phenylalanine -20.0; Alanine - 2.0.

The disadvantage of a biologically active additive is that the mother liquor of sodium humate obtained by treating peat with NaOH reagent is used as a biologically active additive, as a result of which the use of the additive is very limited, since raw materials not traditional for the food industry were used.

Closest to the proposed invention is (the closest analogue) biologically active food supplement "Flavopersin" (liquid in bottles from 10 ml to 100 ml, certificate of state registration RU.77.99.11.003.E.005299.11.16, date of certificate 11/15/2016 g), containing a concentrated aqueous extract of sea buckthorn leaves, a concentrated aqueous extract of peach leaves, E200. The supplement is recommended for improving health in the most serious diseases, when the body is weakened by diseases and drugs.

However, the use of Flavopersin, a biologically active food supplement, has drawbacks, due to the fact that the supplement is available in liquid form, it has less storage stability, active substances are easier to oxidize, and difficult to use.

The objective of the invention is to expand the range of products with immunomodulatory, hypocholesterolemic and antitumor properties with the practical absence of side effects, as well as having a convenient consumer form.

The technical result of the invention is to obtain a biologically active food supplement with the introduction of plant materials with pronounced hypocholesterolemic,

antitumor and immunomodulating properties.

To achieve a technical result, it is proposed to create a composition of active components consisting of dry peach leaf extract, dry sea buckthorn fruit extract, dry cowberry leaf extract, ascorbic acid, tocopherol acetate, beta-carotene, excipients: talc, magnesium and / or calcium stearate, dioxide silicon, lactose in the following ratio of components, wt. %:

composition of active components:

dry peach leaf extract 4.17-8.34 dry sea buckthorn fruit extract 4.17-8.34 dry cowberry leaf extract 4.17-8.34 vitamin C 16.68 tocopherol acetate 50% 12.51 beta carotene 4.17

Excipients:

talc 12.51 magnesium and / or calcium stearate 4.17 silica 4.17 lactose 16.68-4.17

The capsule of a biologically active food supplement consists of: gelatin, glycerin, a copper complex of chlorophyll, a dye - shiny blue 85% in the following ratio of components, wt. %:

gelatin 16.54 glycerin (water-retaining agent) 0.02 chlorophyllin copper complex (dye) 0.02 blue shiny 85% (dye) 0.02

The choice of ingredients and their quantitative ratio in the proposed biologically active food supplement is determined by the characteristics of the active ingredients, which is the basis for the scientific justification of the prescription composition, functional properties and practical use of the developed product.

The extract obtained from peach leaves has a versatile nature of action, this gives reason to use it as a means of enhancing the protective mechanisms and nonspecific resistance of the human body, a means of preventing cancer, a means of improving the quality of life of cancer patients.

Sea buckthorn extract contains a complex of phytosterols, which reduces blood cholesterol and intestinal absorption.

Lingonberry leaf extract has anti-inflammatory and disinfectant properties. The main active ingredient is arbutin glycoside, which has a hypoglycemic effect and promotes the excretion of metabolic products in the urine.

Ascorbic acid has an antibacterial effect, which helps to increase the body's resistance to so-called seasonal infections, and also helps to strengthen the immune system. Possessing powerful antioxidant properties, it helps prevent the formation of free radicals, thereby reducing the risk of tumor formation.

Beta-carotene acts as an antioxidant, protecting the cell membranes from the harmful effects of free radicals. Turning into vitamin A in the body, it helps regulate bone growth, and also participates in the formation of intercellular substance, collagen and elastic fibers of connective tissue. Prevents diseases, especially oncological diseases and heart disorders, helps strengthen the immune system.

Tocopherol acetate prevents the damaging effects of free radicals, inhibits lipid oxidation and the formation of free radicals, which confirms the antioxidant properties of the vitamin. Tocopherol acetate promotes the absorption of fat-soluble vitamins A and D, preventing their oxidation. Tocopherol performs a structural function, interacting with phospholipids of biological membranes, helps to reduce the risk of blood clots, increases the resistance of red blood cells to hemolysis, strengthens blood vessels and is an excellent prophylactic for atherosclerosis and thrombophlebitis. Tocopherol, being an antioxidant, is recommended for the prevention of cancer with chemical and radiation effects on the body, and also helps to produce red blood cells, delays the aging process and helps prevent cancer, diabetes and cardiovascular disease. Increases physical stamina, improving the efficiency of oxygen use by the body.

Magnesium and / or calcium stearate is used to reduce hygroscopicity, as an anti-caking agent,

Talc has a high adsorption capacity.

As a filler, lactose is introduced (to obtain 100 wt.%), To improve the qualitative and quantitative characteristics of the dosage form, but not causing the main pharmacological action of a biologically active food supplement.

Based on experimental studies of the encapsulation process of the proposed biologically active food additives, it was found that in order to ensure high quality products, the encapsulation mass should be 500 mg, and the gelatin capsule should be 100 mg.

Examples of the implementation of the proposed method

Example 1

A biologically active food supplement is prepared as follows, based on 1 capsule, weighing 600 mg, in the following ratio of components, wt. %:

composition of active components:

dry peach leaf extract 4.17 dry sea buckthorn fruit extract 4.17 dry cowberry leaf extract 4.17 vitamin C 16.68 tocopherol acetate 50% 12.51 beta carotene 4.17

Excipients:

talc 12.51 magnesium and / or calcium stearate 4.17 silica 4.17 lactose 16.68

capsule:

gelatin 16.54 glycerol 0.02 chlorophyllin copper complex 0.02 dye blue shiny 85% 0.02

The raw materials used must be accompanied by documents confirming its quality and safety. Next, the dosage of the formulation components is carried out. A hitch of each component is fixed in the routing. Monitoring is carried out on the conformity of the name, quantity and series of raw materials with the technological map. Through a vibrating screen, with a hole diameter of 1 millimeter, it sifts, the screenings are subjected to grinding in a hammer mill, and then re-sieved. When pressing with a pestle on the surface of the mixture, lumps and foreign inclusions should be absent. The resulting components are loaded into a V-shaped mixer and mixed at the rate of 100 kg-1 hour. The mixture is sent to a testing laboratory for analysis and a protocol of compliance with the stated requirements. Next, encapsulation is carried out in hard gelatin capsules and dust removal of the finished capsules. Finished capsules, satisfying in appearance, are weighed and transferred to the stage of filling and packaging.

Example 2

A biologically active food supplement is prepared as follows, based on 1 capsule, weighing 600 mg, in the following ratio of components, wt. %:

composition of active components:

dry peach leaf extract 8.34 dry sea buckthorn fruit extract 8.34 dry cowberry leaf extract 8.34 vitamin C 16.68 tocopherol acetate 50% 12.51 beta carotene 4.17

Excipients:

talc 12.51 magnesium and / or calcium stearate 4.17 silica 4.17 lactose 4.17

capsule:

gelatin 16.54 glycerol 0.02 chlorophyllin copper complex 0.02 dye blue shiny 85% 0.02

The description of the process is analogous to example 1.

The result of the invention is expressed in obtaining a biologically active additive with immunomodulating, hypocholesterolemic, antitumor properties.

Claims (7)

A biologically active food supplement with immunomodulating, hypocholesteric and antitumor properties, characterized in that it is made in the form of capsules weighing 600 mg and contains a composition of active ingredients - dry peach leaf extract, dry sea buckthorn fruit extract, dry cowberry leaf extract, ascorbic acid, tocopherol acetate 50%, beta-carotene, as well as excipients - talc, magnesium and / or calcium stearate, silicon dioxide, lactose and capsule components - gelatin, glycerin, copper set ex chlorophyllin, dye - brilliant blue 85% in the following ratio of components, wt. %: composition of active components: dry peach leaf extract 4.17-8.34 dry sea buckthorn fruit extract 4.17-8.34 dry cowberry leaf extract 4.17-8.34 vitamin C                    16.68 tocopherol acetate 50%                    12.51 beta carotene                                              4.17 Excipients: talc                                                        12.51 magnesium and / or calcium stearate          4.17 silica                                  4.17 lactose                                    4.17-16.68 capsule: gelatin                                             16.54 glycerol                                               0.02 chlorophyllin copper complex           0.02 dye blue shiny 85%           0.02