RU2707254C1 - Водный фармацевтический препарат и способ лечения хронической язвы - Google Patents
Водный фармацевтический препарат и способ лечения хронической язвы Download PDFInfo
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- RU2707254C1 RU2707254C1 RU2016124234A RU2016124234A RU2707254C1 RU 2707254 C1 RU2707254 C1 RU 2707254C1 RU 2016124234 A RU2016124234 A RU 2016124234A RU 2016124234 A RU2016124234 A RU 2016124234A RU 2707254 C1 RU2707254 C1 RU 2707254C1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBPCT/GB2013/053053 | 2013-11-19 | ||
| PCT/GB2013/053053 WO2015075406A1 (en) | 2013-11-19 | 2013-11-19 | New treatment of chronic ulcers |
| PCT/GB2014/053415 WO2015075441A1 (en) | 2013-11-19 | 2014-11-19 | New treatment of chronic ulcers |
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Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808376D0 (en) | 2008-05-08 | 2008-06-18 | Bristol Myers Squibb Co | Wound dressing |
| GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| PL2648795T3 (pl) | 2010-12-08 | 2023-05-08 | Convatec Technologies Inc. | System do usuwania wysięków z miejsca rany |
| CN103347562B (zh) | 2010-12-08 | 2016-08-10 | 康沃特克科技公司 | 伤口分泌液系统附件 |
| CN103347561B (zh) | 2010-12-08 | 2016-09-07 | 康沃特克科技公司 | 用于评估伤口分泌液的集成系统 |
| GB201115182D0 (en) | 2011-09-02 | 2011-10-19 | Trio Healthcare Ltd | Skin contact material |
| GB2497406A (en) | 2011-11-29 | 2013-06-12 | Webtec Converting Llc | Dressing with a perforated binder layer |
| GB201120693D0 (en) | 2011-12-01 | 2012-01-11 | Convatec Technologies Inc | Wound dressing for use in vacuum therapy |
| JP2016507663A (ja) | 2012-12-20 | 2016-03-10 | コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ | 化学修飾セルロース系繊維の加工 |
| WO2015075406A1 (en) | 2013-11-19 | 2015-05-28 | Lipopeptide Ab | New treatment of chronic ulcers |
| JP6738833B2 (ja) | 2015-04-28 | 2020-08-12 | コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ | 抗細菌性ナノファイバー |
| GB2543544A (en) | 2015-10-21 | 2017-04-26 | Brightwake Ltd | Wound dressing |
| US20190142642A1 (en) | 2016-03-30 | 2019-05-16 | Convatec Technologies Inc. | Detecting microbial infections in wounds |
| CN109416355A (zh) | 2016-03-30 | 2019-03-01 | 定性酶诊断有限责任两合公司 | 检测伤口微生物感染 |
| GB201608099D0 (en) | 2016-05-09 | 2016-06-22 | Convatec Technologies Inc | Negative pressure wound dressing |
| CA3030151A1 (en) | 2016-07-08 | 2018-01-11 | Convatec Technologies Inc. | Fluid collection apparatus |
| MX2019000239A (es) | 2016-07-08 | 2019-09-06 | Convatec Technologies Inc | Sistema de presion negativa flexible. |
| TW201805035A (zh) | 2016-07-08 | 2018-02-16 | 美商康瓦鐵克科技股份有限公司 | 流體流動感測 |
| US11795192B2 (en) | 2017-03-10 | 2023-10-24 | Lakewood Amedex, Inc. | Antimicrobial compounds, compositions, and uses thereof |
| DK3638251T3 (da) | 2017-06-12 | 2024-05-13 | Lakewood Amedex Inc | Bisphosphocin gel formuleringer og brug deraf |
| EP4360666A3 (en) | 2017-11-16 | 2024-05-08 | ConvaTec Limited | Fluid collection apparatus |
| AU2019361999A1 (en) | 2018-10-17 | 2021-02-25 | Lakewood Amedex, Inc. | Methods and compositions for treating oral mucositis |
| EP3962544B1 (en) | 2019-06-03 | 2023-11-08 | Convatec Limited | Methods and devices to disrupt and contain pathogens |
| US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
| US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5271943A (en) * | 1989-10-27 | 1993-12-21 | Scott Health Care | Wound gel compositions containing sodium chloride and method of using them |
| US6201164B1 (en) * | 1996-07-11 | 2001-03-13 | Coloplast A/S | Hydrocolloid wound gel |
| US20080226724A1 (en) * | 2007-01-19 | 2008-09-18 | Genentech, Inc. | Prevention of hydrogel viscosity loss |
| US7452864B2 (en) * | 2003-01-29 | 2008-11-18 | Lipopeptide Ab | Use of the cathelicidin LL-37 and derivatives thereof for wound healing |
| WO2009001087A2 (en) * | 2007-06-25 | 2008-12-31 | Lipopeptide Ab | New medical products |
| RU2392962C2 (ru) * | 2004-07-28 | 2010-06-27 | Октоплюс Сайенсиз Б.В. | Противомикробные пептиды |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641483A (en) * | 1995-06-07 | 1997-06-24 | Beaulieu; Andre | Wound healing formulations containing human plasma fibronectin |
| JP4048565B2 (ja) | 1996-04-23 | 2008-02-20 | 東レ株式会社 | 「抗ピロリ菌剤」 |
| US6861067B2 (en) * | 1998-09-17 | 2005-03-01 | Sherwood Services Ag | Hydrogel wound dressing and the method of making and using the same |
| US6835713B2 (en) | 2001-02-16 | 2004-12-28 | University Of Pittsburgh | Virus derived antimicrobial peptides |
| EP1358888A1 (en) | 2002-02-28 | 2003-11-05 | Robert Bals | The human peptide antibiotic LL-37/hCAP-18 is an inducer of angiogenesis |
| US7262179B2 (en) * | 2003-05-28 | 2007-08-28 | Bristol-Myers Squibb Company | Wound care compositions |
| ZA200600686B (en) | 2006-01-24 | 2006-04-26 | Jacobus F Mouton | A wound dressing |
| AU2008289178A1 (en) * | 2007-08-16 | 2009-02-26 | Carnegie Mellon University | Inflammation-regulating compositions and methods |
| JP5553769B2 (ja) * | 2007-12-28 | 2014-07-16 | アウグスティヌス・バーダー | 皮膚創傷治癒のためのエリスロポエチンの局所適用および製剤 |
| US20120213843A1 (en) | 2009-11-03 | 2012-08-23 | Lipidor Ab | Composition for promoting wound healing |
| WO2012033792A2 (en) * | 2010-09-07 | 2012-03-15 | Dmi Acquisition Corp. | Treatment of diseases |
| US9693936B2 (en) * | 2012-03-07 | 2017-07-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Dispersions in oil of Dead Sea nano sized material preparation and uses therof |
| WO2013163423A1 (en) * | 2012-04-25 | 2013-10-31 | Musc Foundation For Research Development | Compositions and methods for wound healing and tissue repair |
| WO2015075406A1 (en) | 2013-11-19 | 2015-05-28 | Lipopeptide Ab | New treatment of chronic ulcers |
-
2013
- 2013-11-19 WO PCT/GB2013/053053 patent/WO2015075406A1/en not_active Ceased
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2014
- 2014-11-14 TW TW103139532A patent/TWI698251B/zh not_active IP Right Cessation
- 2014-11-19 US US15/037,199 patent/US10226508B2/en active Active
- 2014-11-19 RU RU2016124234A patent/RU2707254C1/ru active
- 2014-11-19 BR BR112016011166A patent/BR112016011166A8/pt not_active Application Discontinuation
- 2014-11-19 MX MX2016006091A patent/MX379357B/es unknown
- 2014-11-19 JP JP2016532032A patent/JP6539268B2/ja not_active Expired - Fee Related
- 2014-11-19 KR KR1020167016272A patent/KR102360938B1/ko not_active Expired - Fee Related
- 2014-11-19 EP EP14825175.4A patent/EP3071216B1/en active Active
- 2014-11-19 WO PCT/GB2014/053415 patent/WO2015075441A1/en not_active Ceased
- 2014-11-19 ES ES14825175T patent/ES2925876T3/es active Active
- 2014-11-19 CA CA2927557A patent/CA2927557C/en active Active
- 2014-11-19 AU AU2014351607A patent/AU2014351607B2/en not_active Ceased
- 2014-11-19 PL PL14825175.4T patent/PL3071216T3/pl unknown
- 2014-11-19 CN CN201480063233.4A patent/CN105939726A/zh active Pending
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2016
- 2016-06-17 ZA ZA2016/04110A patent/ZA201604110B/en unknown
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2019
- 2019-01-11 US US16/245,642 patent/US10709760B2/en not_active Expired - Fee Related
-
2020
- 2020-06-04 US US16/893,025 patent/US11191810B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5271943A (en) * | 1989-10-27 | 1993-12-21 | Scott Health Care | Wound gel compositions containing sodium chloride and method of using them |
| US6201164B1 (en) * | 1996-07-11 | 2001-03-13 | Coloplast A/S | Hydrocolloid wound gel |
| US7452864B2 (en) * | 2003-01-29 | 2008-11-18 | Lipopeptide Ab | Use of the cathelicidin LL-37 and derivatives thereof for wound healing |
| RU2392962C2 (ru) * | 2004-07-28 | 2010-06-27 | Октоплюс Сайенсиз Б.В. | Противомикробные пептиды |
| US20080226724A1 (en) * | 2007-01-19 | 2008-09-18 | Genentech, Inc. | Prevention of hydrogel viscosity loss |
| WO2009001087A2 (en) * | 2007-06-25 | 2008-12-31 | Lipopeptide Ab | New medical products |
Non-Patent Citations (2)
| Title |
|---|
| "Pergamum announces final data from Phase I/ll study of LL-37 in patients with chronic leg ulcers", 10 October 2013, Pergamum AB, найдено в Интернет [24.07.18] http://globenewswire.com/Attachment/DownloadAttachment?articleid=579421&fileId=270361&filename=10095394.pdf&filetype=3&islogo=0;. * |
| GRONBERG A. ET AL. "Stability of the cathelicidin peptide LL-37 in a non-healing wound environment". ACTA DERMATO-VENEREOLOGICA, 2011, v.91, no.5, p.511-515. * |
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| BR112016011166A8 (pt) | 2022-06-28 |
| PL3071216T3 (pl) | 2022-11-21 |
| ZA201604110B (en) | 2020-11-25 |
| US10226508B2 (en) | 2019-03-12 |
| TWI698251B (zh) | 2020-07-11 |
| AU2014351607A1 (en) | 2016-06-23 |
| BR112016011166A2 (enExample) | 2017-08-08 |
| JP2016537373A (ja) | 2016-12-01 |
| CN105939726A (zh) | 2016-09-14 |
| US20190255147A1 (en) | 2019-08-22 |
| US10709760B2 (en) | 2020-07-14 |
| CA2927557A1 (en) | 2015-05-28 |
| WO2015075441A1 (en) | 2015-05-28 |
| MX2016006091A (es) | 2016-12-09 |
| AU2014351607B2 (en) | 2020-03-05 |
| CA2927557C (en) | 2023-05-02 |
| KR20160088914A (ko) | 2016-07-26 |
| EP3071216A1 (en) | 2016-09-28 |
| EP3071216B1 (en) | 2022-08-03 |
| US20200384077A1 (en) | 2020-12-10 |
| MX379357B (es) | 2025-03-11 |
| WO2015075406A1 (en) | 2015-05-28 |
| TW201521760A (zh) | 2015-06-16 |
| JP6539268B2 (ja) | 2019-07-03 |
| ES2925876T3 (es) | 2022-10-20 |
| RU2016124234A (ru) | 2017-12-25 |
| US20160271217A1 (en) | 2016-09-22 |
| KR102360938B1 (ko) | 2022-02-09 |
| US11191810B2 (en) | 2021-12-07 |
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