RU2706562C2 - Мультиплексная геномная инженерия, направляемая рнк - Google Patents

Мультиплексная геномная инженерия, направляемая рнк Download PDF

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RU2706562C2
RU2706562C2 RU2016104056A RU2016104056A RU2706562C2 RU 2706562 C2 RU2706562 C2 RU 2706562C2 RU 2016104056 A RU2016104056 A RU 2016104056A RU 2016104056 A RU2016104056 A RU 2016104056A RU 2706562 C2 RU2706562 C2 RU 2706562C2
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cell
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nucleic acid
binding protein
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Джордж М. ЧЁРЧ
Джеймс ДИКАРЛО
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Президент Энд Фэллоуз Оф Харвард Коллидж
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]

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RU2016104056A 2013-07-09 2014-07-08 Мультиплексная геномная инженерия, направляемая рнк RU2706562C2 (ru)

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US201361844168P 2013-07-09 2013-07-09
US61/844,168 2013-07-09
PCT/US2014/045691 WO2015006290A1 (en) 2013-07-09 2014-07-08 Multiplex rna-guided genome engineering

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RU2706562C2 true RU2706562C2 (ru) 2019-11-19

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EP (2) EP4166669A1 (enExample)
JP (4) JP7120717B2 (enExample)
KR (5) KR20260047646A (enExample)
CN (2) CN116042726A (enExample)
AU (3) AU2014287393B2 (enExample)
CA (2) CA3192673A1 (enExample)
ES (1) ES2929143T3 (enExample)
IL (2) IL243475B2 (enExample)
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