RU2704323C1 - Preparation for recovery of cardiovascular system, having cardioprotective, sedative and hypotensive action - Google Patents

Abstract

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to a preparation having cardioprotective, sedative and hypotensive action, which can be used for preventing and adjuvant therapy of cardiovascular diseases. Preparation represents a water-alcohol extract of vegetal raw materials, obtained from Aristolochia manshuriensis stems, Scutellaria baicalensis roots, Paeonia lactiflora roots, Prunella vulgaris herb, Patrinia scabiosifolia herb, leaves and stems of Viscum coloratum, Adonis vernalis herb, Cimicifugae dahuricae root, Valeriana officinalis root, Melissa officinalis herb, Leonurus herb, Crataegus sanguinea berries, Rosa berries, Gnaphalium uliginosum herb, Cichorium intybus herb, Polygonum aviculare herb, Tanacetum flowers, Calendula officinalis flowers, Matricaria chamomilla flowers, Serratula herb, nutmeg, 40 % ethyl alcohol and distilled water taken in certain proportions.

EFFECT: preparation promotes effective recovery of cardiovascular system through suppression of sympathetic nervous system tone, and also widens range of such agents.

1 cl, 2 dwg, 4 tbl

Description

The invention relates to the pharmaceutical industry, in particular to a drug with cardioprotective, sedative and hypotensive effects, which may find applications for the prevention and adjunctive therapy of cardiovascular diseases.

Cardiovascular Disease (CVD) is a group of diseases of the heart and blood vessels. CVD is rightly called an epidemic of the 20th century. For many years they have been the leading cause of mortality in many economically developed countries, including Russia, accounting for 55% of total mortality.

Blood pressure in the body is regulated by a complex multifactorial system of hemodynamic homeostasis, which involves the central and autonomic nervous systems, kidneys, heart, blood vessels of the coagulation and anticoagulation systems, as well as the influence of the neurotransmitter nitrogen nitroxide.

To stabilize hemodynamic homeostasis, various medications are used, including phyto-collection.

Known drug collection of plants for the treatment of cardiovascular diseases, which is a tincture of 41 plants in 70% ethanol [RU 2484843 C1, 06/20/2013]. This tincture is prescribed to patients for 1 tablespoon diluted in 100 g of water, 4-5 times a day for 6 months, i.e. the patient daily ingests 60-75 ml of 70% tincture. This is a rather large dose, because when alcohol is broken down, a noticeable proportion of toxic acetyldehyde is formed in the body.

A known tool for the treatment of cardiovascular diseases, characterized in that it contains the fruits of the common hawthorn, the roots of Valerian officinalis, grass of the motherwort five-bladed, the roots of elecampane high, the roots of licorice naked or Ural, the St. John's wort perforated and the seed of poppy seed, taken in the ratio 1: 1: 1: 1: 1: 1: 2, can be made in the form of 40% or 70% alcohol tincture, syrup, aqueous extract for internal use [RU 2391996 C1, 06/20/2010]. Treatment with this drug is quite lengthy, stabilization of pressure occurs in 15-18 days.

Known drug for the treatment of cardiovascular diseases "Cardiophytum", which provides cardiotonic, coronarolytic, hypotensive, antihypoxic, antithrombotic and sedative effects [RU 2137496 C1, 09/20/1999]. The drug contains tincture of 14 medicinal plants in 40% ethanol. The drug showed a good therapeutic effect, contributed to the preservation of optimal performance, smoothing the manifestation of diencephalic disorders, improving the condition of the body during physical exertion. This drug is selected as a prototype.

However, the preparation “Cardiofit” does not have a proper effect on the central and autonomic nervous systems, because its composition is not enough medicinal plants containing substances that have this effect.

The objective of the invention is the expansion of the arsenal of drugs based on medicinal plant materials intended for the improvement of the human cardiovascular system.

The problem was solved by a drug with cardioprotective, sedative and hypotensive effects, which is a water-alcohol extract of plant materials obtained from stalks of Manchurian kirkason, Scutellaria baicalensis roots, milky flowering peony roots, common blackhead grass, scabiosolum grass leaves, stamen leaves, and Adonis, Cimicifuga daurica roots, Valerian officinalis, Melissa officinalis herb, motherwort herb, hawthorn fruit sleepy rosehips, rose hips, marshmallow herbs, common chicory herbs, bird of highlander, tansy flowers, calendula flowers, pharmacy chamomile flowers, sickle grass, nutmeg, 40% ethyl alcohol and distilled water in the following ratio of components, kg per 100 decaliters of extract :

The stems of the Manchu kirkazon 0.4-0.8 The roots of Scutellaria baicalensis 3.6-4.0 Milky-flowered peony roots 3.6-4.0 Common Black-headed Grass 1.6-2.0 Patrinia herb scabiosol 2.8-4.0 Leaves and stems of mistletoe painted 0.6-0.8 Spring adonis grass 3.6-4.0 The roots of tsimitsifugi daursky 3.6-4.0 The roots of Valerian officinalis 1.6-2.0 Melissa officinalis herb 1.6-2.0 Motherwort herb 1.6-2.0 Fruits of hawthorn blood red 3.6-4.0 Dog-rose fruit 1.6-2.0 Marshmallow grass 0.4-0.8 Chicory herb 1.6-2.0 Highlander's Grass 1.2-1.6 Tansy flowers 0.4-1.0 Marigold flowers 1.6-2.0 Chamomile flowers 1.6-2.0 Grass shepherds 1.6-2.0 Nutmeg 0.8-1.2 Ethyl alcohol 40% 380.0-420.0 Distilled water rest

The technical result - the creation of a new drug, which is a water-alcohol extract of phytosborder containing 21 medicinal plants, which, when used, unlike the prototype, has a healing effect on the cardiovascular system by suppressing the tone of the sympathetic nervous system. As a result, there is a decrease in the rigidity of the vascular system and a decrease in blood pressure in the system of the small and large circles of blood circulation, as well as a decrease in afterload, which leads to an improvement in the contractility of the myocardium and an increase in the efficiency of the functioning of the circulatory system.

The components of the proposed drug in the claimed qualitative and quantitative ratio exhibit synergistic properties, providing its cardioprotective, sedative and hypotensive effects on the cardiovascular system of the body.

The stalks of Manchu kircasone are used as a cardiotonic, sedative, antipyretic, sedative. Helps relieve arrhythmia, increases the contractility of the heart.

The roots of Scutellaria baicalensis are used for hypertension, tachycardia, have a vasodilating, adaptogenic and soothing effect. Decoctions of the roots of Scutellaria eliminate insomnia, increased nervousness, migraine, reduce the functional activity of the central nervous system.

Milk-flowered peony roots are used for diseases of the central nervous system, posthemorrhagic anemia, hypertension. Tincture of marin root is prescribed as a sedative in case of neurasthenic conditions against the background of increased reflex excitability, as well as for the treatment of phobias, vegetative-vascular pathologies.

The herb Chernogolovka vulgaris has a diuretic, antitumor, antipyretic, hemostatic, anti-inflammatory, antispasmodic, tonic effect on the central nervous system.

The herb of patrinia scabiosolus is used for increased irritability, cardiac neurosis, and insomnia.

Leaves and stems of mistletoe are an effective remedy for hypertension, have an antioxidant, lipid-lowering, immunomodulating effect.

Spring adonis herb has a cardiotonic, calming, diuretic effect, slows the heart rate, strengthens systole, prolongs diastole, increases stroke volume of blood, and has moderate inhibition of intracardiac conduction.

The roots of tsimitsifuga daursky have a hypotensive effect, leading to improved cardiac activity, relaxation of smooth muscles of internal organs and increased urine output.

Tincture from the roots of Valerian officinalis has a calming, hypotensive, vasodilating and sedative effect.

Melissa officinalis herb is used for atherosclerosis, hypertension, tachycardia, cardiac neurosis, angina pectoris.

Motherwort herb stabilizes the heart rhythm and strengthens the myocardium, has an antispasmodic and anticonvulsant effect, lowers blood pressure and cholesterol.

The fruits of the hawthorn blood-red significantly improve the work of the heart, soothe, normalize the heart rhythm and protect against overwork, neurosis, normalize the metabolism.

Rose hips are a valuable multivitamin, have phytoncidal and powerful bactericidal properties. They contain a large amount of antioxidants.

Marshmallow grass is used in the initial stage of hypertension, with angina pectoris, gastric and duodenal ulcers, and diabetes mellitus, it has a vasodilating effect.

An infusion of chicory herb has a calming effect on the central nervous system, tones the heart, and has a choleretic effect.

Highlander's grass is used for hypertension, neurosthenia, fever, headache.

Tansy flowers have antispasmodic, anticonvulsant, sedative, diuretic, anti-inflammatory effects.

Calendula flowers have a vasodilating, antispasmodic, sedative, cardiotonic, anticoagulant effect.

Pharmaceutical chamomile flowers have a sedative, antispasmodic, anti-allergic, analgesic effect.

Serpukha grass is recommended for use in various stomach and heart diseases, with anemia and jaundice, as well as with all kinds of neuroses.

Nutmeg is indicated for anxiety, high cholesterol, memory loss, spasms, heart disease, tachycardia. Very small doses of nutmeg can calm the nervous system, restore lost sleep.

The invention is illustrated by the following examples.

Example 1. For the preparation of a water-alcohol extract, medicinal raw materials were taken in the form of phyto-collection of the following content, kg:

The stems of the Manchu kirkazon 0.6 The roots of Scutellaria baicalensis 3.8 Milky-flowered peony roots 3.8 Common Chernogolovka grass 1.8 Herb Patrinia Scabiosolus 3.4 Leaves and stems of mistletoe painted 0.7 Spring adonis grass 3.8 The roots of tsimitsifugi daursky 3.8 The roots of Valerian officinalis 1.8 Melissa officinalis herb 1.8 Motherwort herb 1.8 Fruits of hawthorn blood red 3.8 Dog-rose fruit 1.8 Marshmallow grass 0.6 Chicory herb 1.8 Highlander's Grass 1.4 Tansy flowers 0.7 Marigold flowers 1.8 Chamomile flowers 1.8 Grass shepherds 1.8 Nutmeg 1,0

The above phytobox is suspended in 100 dal of 40% ethanol, insisted for 10 days with daily heating of the mixture to 40 ° C and stirred. Next, the infusion is filtered through belting and poured into 100 ml glass vials. The drug is a brown liquid with a balsamic aroma of essential oils of plants like Valerian officinalis.

The inventive preparation in an amount of 20-30 drops in a dilution with 50 ml of water is used for internal use 1-2 times a day.

Example 2. The study of the effect of the drug on the cardiovascular system.

For this purpose, patients with nosological forms of various etiologies, pathogenesis, and symptoms were selected. Twenty-four volunteers took part in the test — employees of the Far Eastern Branch of the Russian Academy of Sciences aged 25 to 65, including 13 men and 11 women.

The distribution of nosological forms in patients is as follows: hypertension - 15 people, coronary heart disease - 5 people, thyrotoxicosis - 3 people, vegetovascular dystonia with cardiac arrhythmia according to the type of ventricular extrasystole - 1 person.

Studies of the state of the sero-vascular system were carried out twice: the first - background (Mn), the second - one hour after taking 20-30 drops of the inventive preparation (Mr) using a non-invasive printing method. In this case, the parameters of the phase structure of the cardiac cycle, relative and complex indicators of cardiohemodynamics, indicators of central hemodynamics, indicators of the state of the autonomic nervous system, adaptation of the cardiovascular system, and vector assessment of polycardiograms were determined. The results are presented in tables 1-4.

Table 1

Indicators of the phase structure of the heart cycle

Abbreviations Used:

Heart rate - heart rate (bpm)

R-R - the duration of the heart cycle (s)

AS - phase of asynchronous reduction (s)

IC - isometric contraction phase (s)

T - voltage period (s)

E - the period of exile (s)

S _m - mechanical systole (s)

S _a - acoustic systole (s)

S _e - electric systole (s)

D - diastole (s)

Note: the top line in table 1 and the following tables shows the values before taking the drug, the average one hour after taking the lower line - asterisks reflecting statistical significance.

table 2

Relative and complex indicators of cardiodynamics

Abbreviations Used:

KMB - Blumberger mechanical coefficient (rel. Units)

INM - myocardial stress index (%)

VSP - intrasystolic indicator (%)

SP - systolic indicator (rel. Units)

Vi is the average rate of increase in intraventricular pressure (mmHg / s)

Ve is the volumetric ejection rate (ml / sec.)

VIMO - time of expulsion of the minute volume of blood (rel. Units)

Table 3

Indicators of central hemodynamics

Abbreviations Used:

Mak - systolic blood pressure (according to Korotkov) (mmHg)

Min - diastolic blood pressure (according to Korotkov) (mmHg)

IPD - true pulse pressure (mmHg)

LAC - mean pressure in the pulmonary artery (mmHg)

MOK - minute volume of blood circulation (l / min)

UO - stroke volume (ml)

A - the work of the left ventricle (kgm / min)

M - left ventricular contraction power (watts)

RE - left ventricular energy expenditure for the promotion of 1 liter of blood (watts)

W - total vascular peripheral resistance (dyne / s / cm ^-5 )

ЕО - total elastic resistance of the arterial system (dyne / s / cm ^-5 )

EOW - the ratio of the bulk modulus and peripheral resistance (rel. Units)

Table 4

Indicators of the state of the autonomic nervous system, adaptation of the cardiovascular system, vector assessment of polycardiograms

Abbreviations Used:

VIK - Kerdo Vegetative Index (%)

AR - adaptive potential of blood circulation (rel. Units)

VECT - polycardiogram vector (sec)

ALFA - polycardiogram vector angle (degree)

In FIG. 1 is a graph of the results of a vector analysis of polycardiograms.

In the diagram: a circle is a normal zone; ΔFIS - deviation from the proper value.

The upper right area corresponds to the zone of high diastolic pressure syndrome, which is a reflection of the restructuring of the heart in conditions of high blood pressure. Vector in the form of a long arrow - the condition of patients before taking the drug, vector in the form of a short arrow - after taking the claimed drug. The length of the vectors characterizes the severity of pathological changes. Obviously, the test drug showed a noticeable positive effect.

In FIG. 2a is a diagram showing the effect of regulation of the circulatory system.

In FIG. 2b is a diagram showing the dynamics of blood pressure.

Fig. 2c is a diagram showing myocardial contractility.

According to the results of a background examination of the parameters of cardiohemodynamics, changes in the parameters of the chronocardiogram are noted (decrease in heart rate, lengthening of the heart cycle and diastole); relative and complex indicators of cardiohemodynamics (decrease in systolic rate and time of expulsion of the minute volume of blood); central hemodynamics (an increase in systolic and true pulse arterial pressure, peripheral arterial vascular resistance, increased tone of the vascular wall); indicators of adaptation of the cardiovascular system (increase in the adaptive potential of blood circulation and lengthening of the polycardiogram vector). The work of the heart is characterized by increased energy expenditure. This picture of indicators of cardiohemodynamics indicates the tension in the functioning of the circulatory system.

After taking the claimed drug, against the background of some inhibition of the sympathetic nervous system (according to the value of the Kerdo vegetative index), there was a change in the parameters of cardiohemodynamics, which consisted in a reduction in heart rate, lengthening of the diastole, a decrease in systolic rate, time of expulsion of the minute blood volume, decrease in systolic blood pressure, pulse pressure, pressure in the pulmonary artery, reducing the rigidity of the arterial vascular system. The consumption of energy by the myocardium of the left ventricle of the heart for the advancement of blood is reduced, the contractile function of the myocardium is normalized. These changes indicate a decrease in tension in the functioning of the circulatory system after taking the drug.

From the presented diagrams it follows that the claimed drug causes a noticeable decrease in the percentage of patients with tachycardia, high blood pressure and low myocardial contractility.

Claims (2)

The drug has a cardioprotective, sedative and hypotensive effect, which is a water-alcohol extract of plant material obtained from stalks of Manchurian kirkazon, roots of Scutellaria baicalensis, roots of milky-flowered peony, common black-headed grass, patrionia scabiosolifolia grass, leaves and stalks of spring grass, mistletoe , tsimitsifuga daursky roots, Valerian officinalis roots, Melissa officinalis herb, motherwort herb, blood-red hawthorn fruit, shea fruit ovnika, herbs uliginose, chicory ordinary grass, herbs Polygonum avian, tansy flowers, marigold flowers, chamomile flowers, herbs Serratula, walnut nutmeg, 40% ethyl alcohol and distilled water in the following ratio of components per 100 kg of the extract gave: The stems of the Manchu kirkazon 0.4-0.8 The roots of Scutellaria baicalensis 3.6-4.0 Milky-flowered peony roots 3.6-4.0 Common Black-headed Grass 1.6-2.0 Herb Patrinia Scabiosolus 2.8-4.0 Leaves and stems of mistletoe painted 0.6-0.8 Spring adonis grass 3.6-4.0 The roots of tsimitsifugi daursky 3.6-4.0 The roots of Valerian officinalis 1.6-2.0 Melissa officinalis herb 1.6-2.0 Motherwort herb 1.6-2.0 Fruits of hawthorn blood red 3.6-4.0 Dog-rose fruit 1.6-2.0 Marshmallow grass 0.4-0.8 Chicory herb 1.6-2.0 Highlander's Grass 1.2-1.6 Tansy flowers 0.4-1.0 Marigold flowers 1.6-2.0 Chamomile flowers 1.6-2.0 Grass shepherds 1.6-2.0 Nutmeg 0.8-1.2 Ethyl alcohol 40% 380.0-420.0 Distilled water rest

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