RU2702838C2 - Композиции для модуляции экспрессии атаксина 2 - Google Patents

Композиции для модуляции экспрессии атаксина 2 Download PDF

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RU2702838C2
RU2702838C2 RU2016140897A RU2016140897A RU2702838C2 RU 2702838 C2 RU2702838 C2 RU 2702838C2 RU 2016140897 A RU2016140897 A RU 2016140897A RU 2016140897 A RU2016140897 A RU 2016140897A RU 2702838 C2 RU2702838 C2 RU 2702838C2
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modified
seq
ataxin
nucleotide bases
parts
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RU2016140897A
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RU2016140897A3 (enExample
RU2016140897A (ru
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Сьюзан М. Фрэйер
Гене ХАНГ
С. Фрэнк БЕННЕТТ
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Ионис Фармасьютикалз, Инк.
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RU2016140897A 2014-03-19 2015-03-19 Композиции для модуляции экспрессии атаксина 2 RU2702838C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461955705P 2014-03-19 2014-03-19
US61/955,705 2014-03-19
US201461982131P 2014-04-21 2014-04-21
US61/982,131 2014-04-21
PCT/US2015/021608 WO2015143246A1 (en) 2014-03-19 2015-03-19 Compositions for modulating ataxin 2 expression

Related Child Applications (1)

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RU2019130898A Division RU2019130898A (ru) 2014-03-19 2015-03-19 Композиции для модуляции экспрессии атаксина 2

Publications (3)

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RU2016140897A RU2016140897A (ru) 2018-04-19
RU2016140897A3 RU2016140897A3 (enExample) 2018-08-20
RU2702838C2 true RU2702838C2 (ru) 2019-10-11

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RU2016140897A RU2702838C2 (ru) 2014-03-19 2015-03-19 Композиции для модуляции экспрессии атаксина 2
RU2019130898A RU2019130898A (ru) 2014-03-19 2015-03-19 Композиции для модуляции экспрессии атаксина 2

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US (4) US10308934B2 (enExample)
EP (2) EP3978610A3 (enExample)
JP (3) JP6902869B2 (enExample)
KR (1) KR102352589B1 (enExample)
CN (2) CN106103717A (enExample)
AU (2) AU2015231130C1 (enExample)
BR (1) BR112016020472B1 (enExample)
CA (1) CA2942340A1 (enExample)
CL (1) CL2016002346A1 (enExample)
CY (1) CY1124526T1 (enExample)
DK (1) DK3119888T3 (enExample)
ES (1) ES2890677T3 (enExample)
HR (1) HRP20211397T1 (enExample)
HU (1) HUE055877T2 (enExample)
IL (1) IL247600B (enExample)
LT (1) LT3119888T (enExample)
MX (1) MX389437B (enExample)
PL (1) PL3119888T3 (enExample)
PT (1) PT3119888T (enExample)
RS (1) RS62526B1 (enExample)
RU (2) RU2702838C2 (enExample)
SG (2) SG11201607761UA (enExample)
SI (1) SI3119888T1 (enExample)
SM (1) SMT202100562T1 (enExample)
WO (1) WO2015143246A1 (enExample)

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US10006027B2 (en) 2014-03-19 2018-06-26 Ionis Pharmaceuticals, Inc. Methods for modulating Ataxin 2 expression
CA2942340A1 (en) 2014-03-19 2015-09-24 Ionis Pharmaceuticals, Inc. Compositions for modulating ataxin 2 expression
US10533175B2 (en) 2015-09-25 2020-01-14 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating Ataxin 3 expression
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
WO2017087282A1 (en) 2015-11-18 2017-05-26 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease
EP3397288A4 (en) * 2015-12-31 2019-09-11 Ionis Pharmaceuticals, Inc. PROCESS FOR REDUCING ATAXIN-2 EXPRESSION
JOP20190104A1 (ar) * 2016-11-10 2019-05-07 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن atxn3
CA3083582A1 (en) * 2017-10-23 2019-05-02 Prevail Therapeutics, Inc. Gene therapies for neurodegenerative disease
US11434488B2 (en) 2018-05-09 2022-09-06 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing ATXN3 expression
PE20211397A1 (es) 2018-05-22 2021-07-27 Ionis Pharmaceuticals Inc Moduladores de la expresion de apol1
WO2019233922A1 (en) 2018-06-05 2019-12-12 F. Hoffmann-La Roche Ag Oligonucleotides for modulating atxn2 expression
EA202190299A1 (ru) * 2018-07-25 2021-06-11 Ионис Фармасьютикалз, Инк. Соединения и способы для снижения экспрессии atxn2
MA54383A (fr) 2018-12-06 2021-10-13 Biogen Ma Inc Protéine neurofilamenteuse pour guider une intervention thérapeutique dans la sclérose laterale amyotrophique
UY38506A (es) * 2018-12-14 2020-06-30 Biogen Ma Inc Composiciones y metodos para tratar y prevenir la esclerosis lateral amiotrofica
CN109529018B (zh) * 2019-01-10 2021-11-30 南方医科大学南方医院 Atxn2l用于制备逆转胃癌奥沙利铂耐药的药物的用途
US11286485B2 (en) 2019-04-04 2022-03-29 Hoffmann-La Roche Inc. Oligonucleotides for modulating ATXN2 expression
EP3947677A1 (en) * 2019-04-04 2022-02-09 F. Hoffmann-La Roche AG Oligonucleotides for modulating atxn2 expression
WO2022026531A1 (en) * 2020-07-29 2022-02-03 Alnylam Pharmaceuticals, Inc. Atxn2 irna compositions and methods of use thereof for treating or preventing atxn2-associated neurodegenerative diseases
KR20250028434A (ko) * 2022-06-24 2025-02-28 일라이 릴리 앤드 캄파니 Atxn2 rna 간섭 작용제
WO2025067482A1 (zh) * 2023-09-28 2025-04-03 大睿生物 调控atxn2表达的dsrna分子
KR20250178496A (ko) 2024-06-19 2025-12-29 이양원 Pcr 장치

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