RU2702732C1 - Органические соединения - Google Patents

Органические соединения Download PDF

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RU2702732C1
RU2702732C1 RU2017123680A RU2017123680A RU2702732C1 RU 2702732 C1 RU2702732 C1 RU 2702732C1 RU 2017123680 A RU2017123680 A RU 2017123680A RU 2017123680 A RU2017123680 A RU 2017123680A RU 2702732 C1 RU2702732 C1 RU 2702732C1
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Russia
Prior art keywords
pyrazolo
methyl
butoxy
naphthyridin
fluorophenyl
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RU2017123680A
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English (en)
Russian (ru)
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Пэн ЛИ
Хайлинь ЧЖЭН
Гретхен СНАЙДЕР
Лоуренс П. УЭННОГЛ
Джозеф ХЕНДРИК
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Интра-Селлулар Терапиз, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2017123680A 2014-12-06 2015-12-07 Органические соединения RU2702732C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088540P 2014-12-06 2014-12-06
US62/088,540 2014-12-06
PCT/US2015/064331 WO2016090382A1 (en) 2014-12-06 2015-12-07 Organic compounds

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RU2702732C1 true RU2702732C1 (ru) 2019-10-10

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EP (1) EP3226862B1 (cg-RX-API-DMAC7.html)
JP (1) JP6608933B2 (cg-RX-API-DMAC7.html)
KR (1) KR102562576B1 (cg-RX-API-DMAC7.html)
CN (1) CN107205993B (cg-RX-API-DMAC7.html)
AU (1) AU2015357498B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017012005B1 (cg-RX-API-DMAC7.html)
CA (1) CA2969597C (cg-RX-API-DMAC7.html)
HK (2) HK1244427A1 (cg-RX-API-DMAC7.html)
IL (1) IL252578B (cg-RX-API-DMAC7.html)
MX (1) MX373320B (cg-RX-API-DMAC7.html)
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HK1244427A1 (zh) * 2014-12-06 2018-08-10 Intra-Cellular Therapies, Inc. 有机化合物
US9628116B2 (en) 2015-07-14 2017-04-18 At&T Intellectual Property I, L.P. Apparatus and methods for transmitting wireless signals
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
TWI782056B (zh) * 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
CN119330979A (zh) 2018-04-13 2025-01-21 癌症研究技术有限公司 作为bcl6抑制剂的化合物及其制备方法
CN112585128B (zh) * 2018-06-18 2023-02-21 詹森药业有限公司 作为malt1抑制剂的吡唑衍生物
EP3909583A4 (en) 2019-01-11 2022-08-17 Shionogi & Co., Ltd DIHYDROPYRAZOLOPYRAZINONE DERIVATIVES WITH MGAT2 INHIBITORY ACTIVITY
KR20210151880A (ko) 2019-04-11 2021-12-14 얀센 파마슈티카 엔.브이. Malt1 억제제로서의 피리딘 고리 함유 유도체
GB201914860D0 (en) * 2019-10-14 2019-11-27 Cancer Research Tech Ltd Inhibitor compounds
CN112851667B (zh) * 2019-11-28 2022-09-09 暨南大学 含氮并杂环类化合物及其药用组合物和应用
KR20210109406A (ko) 2020-02-27 2021-09-06 주식회사 재원인더스트리 열 교환기능을 구비한 환기모듈
CN114539263B (zh) * 2020-11-11 2023-04-25 暨南大学 一类含氮并杂环化合物及其药用组合物和应用

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