RU2695650C2 - Ингибиторы аргиназы и способы их применения - Google Patents
Ингибиторы аргиназы и способы их применения Download PDFInfo
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- RU2695650C2 RU2695650C2 RU2013145548A RU2013145548A RU2695650C2 RU 2695650 C2 RU2695650 C2 RU 2695650C2 RU 2013145548 A RU2013145548 A RU 2013145548A RU 2013145548 A RU2013145548 A RU 2013145548A RU 2695650 C2 RU2695650 C2 RU 2695650C2
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- Prior art keywords
- amino
- propyl
- borono
- compound
- acid
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| ES2568680T3 (es) | 2010-10-26 | 2016-05-03 | Mars, Incorporated | Boratos como inhibidores de arginasa |
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| CA2944903A1 (en) | 2014-04-24 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
| PL410665A1 (pl) * | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| MX385315B (es) | 2015-06-23 | 2025-03-14 | Calithera Biosciences Inc | Composiciones y metodos para inhibir actividad de arginasa. |
| CN108601767A (zh) * | 2015-10-05 | 2018-09-28 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法 |
| CA3001964A1 (en) | 2015-10-16 | 2017-04-20 | Takeda Pharmaceutical Company Limited | Method for producing heterocyclic compound |
| TWI710565B (zh) | 2015-10-30 | 2020-11-21 | 美商卡利泰拉生物科技公司 | 用於抑制精胺酸酶活性之組合物及方法 |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| CA3042878A1 (en) | 2016-11-08 | 2018-05-17 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
| MX378460B (es) * | 2016-12-22 | 2025-03-10 | Calithera Biosciences Inc | Composiciones y métodos para inhibir la actividad de la arginasa. |
| BR112019023582A2 (pt) | 2017-05-12 | 2020-06-02 | Calithera Biosciences Inc. | Método de preparar (3r,4s)-3-acetamido-4-alil-n-(terc-butil)pirrolidina-3-carboxamida |
| CA3091365A1 (en) | 2018-02-17 | 2019-08-22 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| EA202092086A1 (ru) | 2018-03-05 | 2021-02-09 | Аркус Байосайенсиз, Инк. | Ингибиторы аргиназы |
| WO2019177873A1 (en) * | 2018-03-13 | 2019-09-19 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| PL3774843T3 (pl) | 2018-03-29 | 2022-11-14 | Molecure Sa | Dipeptydowe pochodne piperydyny |
| CN111770756B (zh) * | 2018-04-27 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途 |
| US11274111B2 (en) | 2018-06-20 | 2022-03-15 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| AU2019379808C1 (en) | 2018-11-16 | 2024-01-25 | Arcus Biosciences, Inc. | Inhibitors of ARG1 and/or ARG2 |
| WO2020131598A1 (en) | 2018-12-18 | 2020-06-25 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| JP7579324B2 (ja) * | 2019-07-23 | 2024-11-07 | アストラゼネカ・アクチエボラーグ | アルギナーゼ阻害剤及びその使用方法 |
| US20230149521A1 (en) * | 2020-04-17 | 2023-05-18 | Bio-Cancer Treatment International Limited | Methods of treating viral infections using arginase |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
| US20240298987A1 (en) * | 2021-06-23 | 2024-09-12 | Yale University | Compounds For Molecular Imaging of Collagen Turnover and Methods Using Same |
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| ES2273365T3 (es) * | 1996-03-29 | 2007-05-01 | Ortho-Mcneil Pharmaceutical, Inc. | Amidinohidrazonas utiles como inhibidores de proteasa. |
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| EP1049660A1 (en) * | 1997-10-10 | 2000-11-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting arginase activity |
| ATE344246T1 (de) * | 1997-11-26 | 2006-11-15 | Ortho Mcneil Pharm Inc | Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer |
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| CN101932599A (zh) * | 2005-11-10 | 2010-12-29 | 阿波罗生命科学有限公司 | 分子及其嵌合分子 |
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