RU2684216C2 - Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа - Google Patents

Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа Download PDF

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RU2684216C2
RU2684216C2 RU2015120601A RU2015120601A RU2684216C2 RU 2684216 C2 RU2684216 C2 RU 2684216C2 RU 2015120601 A RU2015120601 A RU 2015120601A RU 2015120601 A RU2015120601 A RU 2015120601A RU 2684216 C2 RU2684216 C2 RU 2684216C2
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erfe
hepcidin
iron
erythroferron
mice
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RU2015120601A
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RU2015120601A (ru
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Томас ГАНЗ
Элизабета НЕМЕТ
Леон КАУТЦ
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Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
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    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01N2333/52Assays involving cytokines
    • G01N2333/525Tumor necrosis factor [TNF]
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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RU2015120601A 2012-11-01 2013-10-31 Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа RU2684216C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261721322P 2012-11-01 2012-11-01
US61/721,322 2012-11-01
PCT/US2013/067771 WO2014071015A1 (en) 2012-11-01 2013-10-31 Erythroferrone and erfe polypeptides and methods of regulating iron metabolism

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RU2015120601A RU2015120601A (ru) 2016-12-20
RU2684216C2 true RU2684216C2 (ru) 2019-04-04

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US (2) US20160122409A1 (cg-RX-API-DMAC7.html)
EP (1) EP2914619B1 (cg-RX-API-DMAC7.html)
JP (1) JP6501362B2 (cg-RX-API-DMAC7.html)
KR (1) KR102186218B1 (cg-RX-API-DMAC7.html)
CN (1) CN104854130A (cg-RX-API-DMAC7.html)
AU (1) AU2013337808B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015009954A2 (cg-RX-API-DMAC7.html)
CA (1) CA2890040A1 (cg-RX-API-DMAC7.html)
ES (1) ES2731609T3 (cg-RX-API-DMAC7.html)
RU (1) RU2684216C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014071015A1 (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102405111B1 (ko) * 2016-04-27 2022-06-02 블라디미르 바드마에브 쇼가올을 이용한 철 항상성 유지 방법
WO2018027184A1 (en) * 2016-08-05 2018-02-08 Silarus Therapeutics, Inc. Erfe specific antibodies compositions and methods of use
EP3519432A1 (en) * 2016-10-03 2019-08-07 Silarus Therapeutics, Inc. Erfe fusion polypeptides compositions and methods of use
EP3595718A4 (en) * 2017-03-13 2021-05-26 Intrinsic LifeSciences LLC ANTIBODIES DIRECTED AGAINST ERYTHROFERRONE AND THEIR USES
US11612595B2 (en) * 2017-05-16 2023-03-28 Generos Biopharma Ltd. Compositions and methods for treating rheumatoid arthritis
US11255865B2 (en) 2017-06-06 2022-02-22 The Regents Of The University Of California Immunoassay for human erythroferrone
TW201945026A (zh) * 2018-01-29 2019-12-01 美商希拉諾斯醫療公司 結合erfe之抗體及使用方法
WO2019212364A1 (en) * 2018-05-01 2019-11-07 Christopher Joseph Pemberton Test for heart failure
CA3045370A1 (en) * 2018-06-08 2019-12-08 Pfizer Inc. Methods of treating metabolic disease
US20220119516A1 (en) * 2019-01-16 2022-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Variants of erythroferrone and their use
AU2020356575A1 (en) 2019-09-27 2022-04-14 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
EP4149548A4 (en) 2020-05-13 2024-05-08 Disc Medicine, Inc. ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
EP4665354A1 (en) 2023-02-13 2025-12-24 Institut National de la Santé et de la Recherche Médicale Methods of treatment of iron overload associated diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006046073A2 (en) * 2004-10-28 2006-05-04 Ares Trading S.A. C1q related protein
RU2359268C2 (ru) * 2002-11-19 2009-06-20 ДиАрДжи ИНТЕРНЭШНЛ, ИНК. Способ диагностики заболеваний путем скрининга тканей, крови или жидкостей организма животных или человека на предмет обнаружения нефизиологических уровней гепсидина и его терапевтическое применение

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2335719B1 (en) * 2005-02-16 2015-06-24 The General Hospital Corporation Use of hemojuvelin fusion proteins to regulate hepcidin-mediated iron metabolism
TW200900420A (en) * 2007-02-02 2009-01-01 Amgen Inc Hepcidin, hepcidin antagonists and methods of use
GB0818273D0 (en) * 2008-10-06 2008-11-12 Cambridge Entpr Ltd Modulation of cellular activity and differentiation
AU2009322260B2 (en) * 2008-12-05 2013-09-12 The Regents Of The University Of California Mini-hepcidin peptides and methods of using thereof
WO2013112663A1 (en) * 2012-01-26 2013-08-01 The Johns Hopkins University Myonectin (ctrp15), compositions comprising same, and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2359268C2 (ru) * 2002-11-19 2009-06-20 ДиАрДжи ИНТЕРНЭШНЛ, ИНК. Способ диагностики заболеваний путем скрининга тканей, крови или жидкостей организма животных или человека на предмет обнаружения нефизиологических уровней гепсидина и его терапевтическое применение
WO2006046073A2 (en) * 2004-10-28 2006-05-04 Ares Trading S.A. C1q related protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SELDIN M.M. ET AL. Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, v. 287, n. 15, p.11968-11980. *

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EP2914619A1 (en) 2015-09-09
AU2013337808A1 (en) 2015-05-14
AU2013337808B2 (en) 2017-12-21
EP2914619B1 (en) 2019-05-29
CN104854130A (zh) 2015-08-19
KR102186218B1 (ko) 2020-12-03
JP6501362B2 (ja) 2019-04-17
ES2731609T3 (es) 2019-11-18
KR20150077471A (ko) 2015-07-07
CA2890040A1 (en) 2014-05-08
RU2015120601A (ru) 2016-12-20
US20180355008A1 (en) 2018-12-13
JP2015536337A (ja) 2015-12-21
BR112015009954A2 (pt) 2017-08-22
US20160122409A1 (en) 2016-05-05
WO2014071015A1 (en) 2014-05-08
EP2914619A4 (en) 2016-05-11

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