RU2679661C1 - Применение антагониста опиоидных рецепторов с k-активностью и вортиоксетина для лечения депрессивного расстройства с меланхолическими признаками - Google Patents

Применение антагониста опиоидных рецепторов с k-активностью и вортиоксетина для лечения депрессивного расстройства с меланхолическими признаками Download PDF

Info

Publication number
RU2679661C1
RU2679661C1 RU2016123972A RU2016123972A RU2679661C1 RU 2679661 C1 RU2679661 C1 RU 2679661C1 RU 2016123972 A RU2016123972 A RU 2016123972A RU 2016123972 A RU2016123972 A RU 2016123972A RU 2679661 C1 RU2679661 C1 RU 2679661C1
Authority
RU
Russia
Prior art keywords
vortioxetine
activity
opioid antagonist
nalmefene
treatment
Prior art date
Application number
RU2016123972A
Other languages
English (en)
Russian (ru)
Other versions
RU2016123972A (ru
Inventor
Конни Санчез Морилло
Геннадий Н. СМАГИН
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52146489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2679661(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of RU2016123972A publication Critical patent/RU2016123972A/ru
Application granted granted Critical
Publication of RU2679661C1 publication Critical patent/RU2679661C1/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2016123972A 2013-12-20 2014-12-18 Применение антагониста опиоидных рецепторов с k-активностью и вортиоксетина для лечения депрессивного расстройства с меланхолическими признаками RU2679661C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201300710 2013-12-20
DKPA201300710 2013-12-20
DKPA201400590 2014-10-16
DKPA201400590 2014-10-16
PCT/EP2014/078515 WO2015091833A1 (en) 2013-12-20 2014-12-18 Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features

Publications (2)

Publication Number Publication Date
RU2016123972A RU2016123972A (ru) 2018-01-25
RU2679661C1 true RU2679661C1 (ru) 2019-02-12

Family

ID=52146489

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016123972A RU2679661C1 (ru) 2013-12-20 2014-12-18 Применение антагониста опиоидных рецепторов с k-активностью и вортиоксетина для лечения депрессивного расстройства с меланхолическими признаками

Country Status (14)

Country Link
US (1) US10376506B2 (enExample)
EP (1) EP3082815B1 (enExample)
JP (1) JP6448645B2 (enExample)
KR (1) KR20160093025A (enExample)
CN (1) CN105828821B (enExample)
AU (1) AU2014368548B2 (enExample)
CA (1) CA2933733A1 (enExample)
CL (1) CL2016001570A1 (enExample)
ES (1) ES2694352T3 (enExample)
IL (1) IL246253A0 (enExample)
MX (1) MX368870B (enExample)
RU (1) RU2679661C1 (enExample)
SG (1) SG11201604944PA (enExample)
WO (1) WO2015091833A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA45532A (fr) * 2016-07-01 2019-05-08 H Lundbeck As Schémas posologiques de la vortioxétine destinés à une apparition rapide de l'effet antidépresseur
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
AU2019376633B2 (en) 2018-11-06 2025-08-14 Purdue Pharma L.P. Compositions and methods for opioid antagonist delivery
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
TW202345796A (zh) 2022-03-07 2023-12-01 美商健生醫藥公司 阿替卡普蘭(aticaprant)之形式
KR20240152410A (ko) 2022-03-07 2024-10-21 얀센 파마슈티칼즈, 인코포레이티드 아티카프란트를 포함하는 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200802104A1 (ru) * 2006-04-04 2009-04-28 Хольгер Ларс Герман Применение композиций, содержащих антагонисты каппа-опиоидных рецепторов, для лечения диссоциативных расстройств
EA017432B1 (ru) * 2007-12-14 2012-12-28 Х. Лундбекк А/С 4-[2,3-дифтор-6-(2-фтор-4-метилфенилсульфанил)фенил]пиперидин
US20130289061A1 (en) * 2009-08-13 2013-10-31 The General Hospital Corporation Methods and compositions to prevent addiction

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013740A (en) 1990-03-22 1991-05-07 Hillel Glover Method for treating emotional numbness and coma
US5028612A (en) 1990-03-22 1991-07-02 Hillel Glover Method for treating emotional numbness
US5512593A (en) * 1993-03-02 1996-04-30 John S. Nagle Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor
US6528518B2 (en) * 2000-12-21 2003-03-04 The Mclean Hospital Corporation Treatment of depression with kappa receptor antagonists
US20030087896A1 (en) * 2001-08-09 2003-05-08 Hillel Glover Treatment of refractory depression with an opiate antagonist and an antidepressant
JP2005508888A (ja) * 2001-08-14 2005-04-07 バイオティ セラピーズ コーポレイション アルコール依存症またはアルコール中毒を治療する方法
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
US20030181475A1 (en) 2002-03-20 2003-09-25 Euro-Celtique S.A. Method of administering buprenorphine to treat depression
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
AR058239A1 (es) * 2005-11-28 2008-01-23 Orexigen Therapeutics Inc Metodos para tratar trastornos de ansiedad
CN101432011A (zh) * 2006-02-27 2009-05-13 亚历山大·米哈洛 通过诱导逆适应调节神经递质系统的方法
WO2008066916A1 (en) 2006-11-30 2008-06-05 The Mclean Hospital Corporation Methods for the treatment of mood disorders
US20070259939A1 (en) * 2006-05-04 2007-11-08 Accelerated Technologies Using naltrexone as a multi-purpose health supplement to improve the human condition and preventing multiple diseases and infirmities by stimulating immune system vitality and robustness
EA015287B1 (ru) 2006-06-16 2011-06-30 Х. Лундбекк А/С 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазин в качестве соединения с сочетанием активности в отношении повторного захвата серотонина, 5-нти 5-нтдля лечения когнитивного нарушения
TW200848411A (en) 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
TW200932233A (en) * 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
HRP20160110T1 (hr) 2009-05-25 2016-03-11 H. Lundbeck A/S Priprema nalmefen hidroklorida iz naltreksona
KR101820181B1 (ko) 2010-04-30 2018-02-28 다케다 야쿠힌 고교 가부시키가이샤 장용성 정제
CA2815093C (en) 2010-11-05 2019-08-06 H. Lundbeck A/S Method for the manufacturing of naltrexone
CA2899455C (en) * 2013-01-30 2021-06-08 Pharmorx Therapeutics, Inc. Treatments for depression and other diseases with a low dose agent
JP6479766B2 (ja) 2013-04-17 2019-03-06 ハー・ルンドベック・アクチエゼルスカベット 不安障害患者の治療のためのナルメフェン
US20160058753A1 (en) * 2013-04-17 2016-03-03 H. Lundbeck A/S Nalmefene for Treatment of Patients with Mood Disorder

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200802104A1 (ru) * 2006-04-04 2009-04-28 Хольгер Ларс Герман Применение композиций, содержащих антагонисты каппа-опиоидных рецепторов, для лечения диссоциативных расстройств
EA014820B1 (ru) * 2006-04-04 2011-02-28 Эмодис Гмбх Применение композиций, содержащих антагонист каппа-опиоидных рецепторов бупренорфин, для лечения эмоционально неустойчивых расстройств личности
EA017432B1 (ru) * 2007-12-14 2012-12-28 Х. Лундбекк А/С 4-[2,3-дифтор-6-(2-фтор-4-метилфенилсульфанил)фенил]пиперидин
US20130289061A1 (en) * 2009-08-13 2013-10-31 The General Hospital Corporation Methods and compositions to prevent addiction

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARLEZON W.A. et al. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 September; 123(3): 334-343, , глава KOR Antagonists. Potential for clinical use. *
CHEN G. et al. Pharmacokinetic drug interactions involving vortioxetine (LU AA21004), a multimodal antidepressant. Clin. Drug Investig. (2013) 33: 727-728. Published on line: 23 August 2013, глава Introduction. *
KEATING G.M. Nalmefene: a review of its use in the treatment of alcohol dependence. CNS Drugs (2013) 27: 761-772. Published online: 16 August 2013. *
KEATING G.M. Nalmefene: a review of its use in the treatment of alcohol dependence. CNS Drugs (2013) 27: 761-772. Published online: 16 August 2013. KEATING G.M. Nalmefene: a review of its use in the treatment of alcohol dependence. CNS Drugs (2013) 27: 761-772. Published online: 16 August 2013. MIZUSHIMA J. et al. Melancholic and reactive depression: a reappraisal of old categories. BMC Psychiatry. 2013 Nov 16; 13: 311 [он лайн] [найдено 20.08.2018] (найдено из интернет :www.ncbi.nlm.nih.gov/pubmed/24237589). CARLEZON W.A. et al. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 September; 123(3): 334-343, реферат, глава KOR Antagonists. Potential for clinical use. CHEN G. et al. Pharmacokinetic drug interactions involving vortioxetine (LU AA21004), a multimodal antidepressant. Clin. Drug Investig. (2013) 33: 727-728. Published on line: 23 August 2013, глава Introduction. *
MIZUSHIMA J. et al. Melancholic and reactive depression: a reappraisal of old categories. BMC Psychiatry. 2013 Nov 16; 13: 311 [он лайн] [найдено 20.08.2018] (найдено из интернет :www.ncbi.nlm.nih.gov/pubmed/24237589). *

Also Published As

Publication number Publication date
SG11201604944PA (en) 2016-07-28
AU2014368548A1 (en) 2016-06-30
EP3082815B1 (en) 2018-10-03
CL2016001570A1 (es) 2016-12-09
RU2016123972A (ru) 2018-01-25
CN105828821A (zh) 2016-08-03
CN105828821B (zh) 2019-04-09
MX2016007947A (es) 2016-09-09
CA2933733A1 (en) 2015-06-25
ES2694352T3 (es) 2018-12-20
KR20160093025A (ko) 2016-08-05
US20160310488A1 (en) 2016-10-27
US10376506B2 (en) 2019-08-13
MX368870B (es) 2019-10-21
EP3082815A1 (en) 2016-10-26
JP2016540030A (ja) 2016-12-22
IL246253A0 (en) 2016-07-31
AU2014368548B2 (en) 2019-09-19
JP6448645B2 (ja) 2019-01-09
WO2015091833A1 (en) 2015-06-25

Similar Documents

Publication Publication Date Title
RU2679661C1 (ru) Применение антагониста опиоидных рецепторов с k-активностью и вортиоксетина для лечения депрессивного расстройства с меланхолическими признаками
JP2024091801A (ja) 物質乱用の治療方法
RU2492858C2 (ru) Композиции и способы профилактики и лечения зависимостей
JP2009517393A (ja) 不安症の治療方法
CA2414500A1 (en) Agonist-aversive combination medicines
CA2909506A1 (en) Nalmefene for treatment of patients with anxiety disorder
ES2337622T3 (es) Uso de composiciones que contienen antagonistas del receptor opioide kappa para el tratamiento de trastornos disociativos.
Uys et al. Pharmacological aspects of the combined use of 3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature
JP2021511338A (ja) 睡眠障害の治療及び予防
US20070053976A1 (en) Novel combination of drugs as antidepressant
H Rezvani et al. Novel medication targets for the treatment of alcoholism: preclinical studies
KR20010031470A (ko) 포유동물의 갈망을 감소시키는 방법
EP2138174A1 (en) Pharmaceutical composition in the form of a sublingual tablet consisting of a non-steroidal anti-inflammatory agent and an opiate analgesic for pain management
CA3073186C (en) Synergistic pharmaceutical combination of the active enantiomer s-ketorolac tromethamine and tramadol chlorhydrate
Aubel et al. Evidence for adenosine-and serotonin-mediated antihyperalgesic effects of cizolirtine in rats suffering from diabetic neuropathy
EP1942891B1 (en) Novel combination of drugs as antidepressant
HK1229240A1 (en) Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features
HK1229240B (en) Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features
Serani et al. Mechanisms Of Opioid-Induced Hyperalgesia: Implications For Chronic Pain Management
Volonteri et al. Clinical outcome and tolerability of duloxetine in the treatment of major depressive disorder: a 12-week study with plasma levels
JP6416213B2 (ja) 気分障害患者の治療のためのナルメフェン
Schifano Drug abuse: treatment and management
Watson et al. Toxicity of agents used for opioid withdrawal: a case-based approach
Vivian et al. Oral self-administration of ethanol, phencyclidine, methadone, pentobarbital and quinine in rhesus monkeys
Aubin Acamprosate in clinical practice: The French experience

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20201219