RU2679661C1 - Применение антагониста опиоидных рецепторов с k-активностью и вортиоксетина для лечения депрессивного расстройства с меланхолическими признаками - Google Patents
Применение антагониста опиоидных рецепторов с k-активностью и вортиоксетина для лечения депрессивного расстройства с меланхолическими признаками Download PDFInfo
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- vortioxetine
- activity
- opioid antagonist
- nalmefene
- treatment
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| MA45532A (fr) * | 2016-07-01 | 2019-05-08 | H Lundbeck As | Schémas posologiques de la vortioxétine destinés à une apparition rapide de l'effet antidépresseur |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| US11865112B2 (en) | 2018-11-06 | 2024-01-09 | Purdue Pharma L.P. | Compositions and methods for opioid antagonist delivery |
| US11266627B1 (en) | 2021-05-04 | 2022-03-08 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| US12161622B2 (en) | 2021-05-04 | 2024-12-10 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| CA3254546A1 (en) | 2022-03-07 | 2023-09-14 | Janssen Pharmaceuticals, Inc. | COMPOSITIONS CONTAINING ATICAPRANT |
| CN119156211A (zh) | 2022-03-07 | 2024-12-17 | 杨森制药公司 | 用于治疗重性抑郁障碍的多晶型形式的阿替卡普兰 |
| TW202547487A (zh) * | 2024-03-18 | 2025-12-16 | 學校法人東京理科大學 | 失樂症的治療或預防用醫藥組成物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200802104A1 (ru) * | 2006-04-04 | 2009-04-28 | Хольгер Ларс Герман | Применение композиций, содержащих антагонисты каппа-опиоидных рецепторов, для лечения диссоциативных расстройств |
| EA017432B1 (ru) * | 2007-12-14 | 2012-12-28 | Х. Лундбекк А/С | 4-[2,3-дифтор-6-(2-фтор-4-метилфенилсульфанил)фенил]пиперидин |
| US20130289061A1 (en) * | 2009-08-13 | 2013-10-31 | The General Hospital Corporation | Methods and compositions to prevent addiction |
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| US5013740A (en) | 1990-03-22 | 1991-05-07 | Hillel Glover | Method for treating emotional numbness and coma |
| US5028612A (en) | 1990-03-22 | 1991-07-02 | Hillel Glover | Method for treating emotional numbness |
| US5512593A (en) * | 1993-03-02 | 1996-04-30 | John S. Nagle | Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor |
| JP2004518654A (ja) | 2000-12-21 | 2004-06-24 | ザ マクレーン ホスピタル コーポレーション | 鬱病の治療法 |
| US20030087896A1 (en) | 2001-08-09 | 2003-05-08 | Hillel Glover | Treatment of refractory depression with an opiate antagonist and an antidepressant |
| EP1423116A1 (en) * | 2001-08-14 | 2004-06-02 | Biotie Therapies Corp. | Method of treating alcoholism or alcohol abuse |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| PT1485051E (pt) * | 2002-03-20 | 2008-07-09 | Euro Celtique Sa | Processo de administração da buprenorfina para o tratamento da depressão |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| JP2009517393A (ja) * | 2005-11-28 | 2009-04-30 | オレキシジェン・セラピューティクス・インコーポレーテッド | 不安症の治療方法 |
| CN101432011A (zh) * | 2006-02-27 | 2009-05-13 | 亚历山大·米哈洛 | 通过诱导逆适应调节神经递质系统的方法 |
| WO2008066916A1 (en) | 2006-11-30 | 2008-06-05 | The Mclean Hospital Corporation | Methods for the treatment of mood disorders |
| US20070259939A1 (en) | 2006-05-04 | 2007-11-08 | Accelerated Technologies | Using naltrexone as a multi-purpose health supplement to improve the human condition and preventing multiple diseases and infirmities by stimulating immune system vitality and robustness |
| MY150647A (en) | 2006-06-16 | 2014-02-14 | Lundbeck & Co As H | 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment |
| TW200848411A (en) | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
| TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
| EA019331B1 (ru) | 2009-05-25 | 2014-02-28 | Х. Лундбекк А/С | Получение налмефена гидрохлорида из налтрексона |
| WO2011136376A1 (ja) | 2010-04-30 | 2011-11-03 | 武田薬品工業株式会社 | 腸溶性錠剤 |
| AU2011325563B2 (en) | 2010-11-05 | 2015-08-20 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| CA2899455C (en) * | 2013-01-30 | 2021-06-08 | Pharmorx Therapeutics, Inc. | Treatments for depression and other diseases with a low dose agent |
| CA2909506C (en) | 2013-04-17 | 2021-04-20 | H. Lundbeck A/S | Nalmefene for treatment of patients with anxiety disorder |
| JP6416213B2 (ja) * | 2013-04-17 | 2018-10-31 | ハー・ルンドベック・アクチエゼルスカベット | 気分障害患者の治療のためのナルメフェン |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200802104A1 (ru) * | 2006-04-04 | 2009-04-28 | Хольгер Ларс Герман | Применение композиций, содержащих антагонисты каппа-опиоидных рецепторов, для лечения диссоциативных расстройств |
| EA014820B1 (ru) * | 2006-04-04 | 2011-02-28 | Эмодис Гмбх | Применение композиций, содержащих антагонист каппа-опиоидных рецепторов бупренорфин, для лечения эмоционально неустойчивых расстройств личности |
| EA017432B1 (ru) * | 2007-12-14 | 2012-12-28 | Х. Лундбекк А/С | 4-[2,3-дифтор-6-(2-фтор-4-метилфенилсульфанил)фенил]пиперидин |
| US20130289061A1 (en) * | 2009-08-13 | 2013-10-31 | The General Hospital Corporation | Methods and compositions to prevent addiction |
Non-Patent Citations (5)
| Title |
|---|
| CARLEZON W.A. et al. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 September; 123(3): 334-343, , глава KOR Antagonists. Potential for clinical use. * |
| CHEN G. et al. Pharmacokinetic drug interactions involving vortioxetine (LU AA21004), a multimodal antidepressant. Clin. Drug Investig. (2013) 33: 727-728. Published on line: 23 August 2013, глава Introduction. * |
| KEATING G.M. Nalmefene: a review of its use in the treatment of alcohol dependence. CNS Drugs (2013) 27: 761-772. Published online: 16 August 2013. * |
| KEATING G.M. Nalmefene: a review of its use in the treatment of alcohol dependence. CNS Drugs (2013) 27: 761-772. Published online: 16 August 2013. KEATING G.M. Nalmefene: a review of its use in the treatment of alcohol dependence. CNS Drugs (2013) 27: 761-772. Published online: 16 August 2013. MIZUSHIMA J. et al. Melancholic and reactive depression: a reappraisal of old categories. BMC Psychiatry. 2013 Nov 16; 13: 311 [он лайн] [найдено 20.08.2018] (найдено из интернет :www.ncbi.nlm.nih.gov/pubmed/24237589). CARLEZON W.A. et al. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 September; 123(3): 334-343, реферат, глава KOR Antagonists. Potential for clinical use. CHEN G. et al. Pharmacokinetic drug interactions involving vortioxetine (LU AA21004), a multimodal antidepressant. Clin. Drug Investig. (2013) 33: 727-728. Published on line: 23 August 2013, глава Introduction. * |
| MIZUSHIMA J. et al. Melancholic and reactive depression: a reappraisal of old categories. BMC Psychiatry. 2013 Nov 16; 13: 311 [он лайн] [найдено 20.08.2018] (найдено из интернет :www.ncbi.nlm.nih.gov/pubmed/24237589). * |
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| US20160310488A1 (en) | 2016-10-27 |
| JP6448645B2 (ja) | 2019-01-09 |
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