RU2674995C2 - Фармацевтические комбинации - Google Patents

Фармацевтические комбинации Download PDF

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Publication number
RU2674995C2
RU2674995C2 RU2015124954A RU2015124954A RU2674995C2 RU 2674995 C2 RU2674995 C2 RU 2674995C2 RU 2015124954 A RU2015124954 A RU 2015124954A RU 2015124954 A RU2015124954 A RU 2015124954A RU 2674995 C2 RU2674995 C2 RU 2674995C2
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RU
Russia
Prior art keywords
compound
melanoma
inhibitor compound
pharmaceutically acceptable
combination
Prior art date
Application number
RU2015124954A
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English (en)
Russian (ru)
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RU2015124954A (ru
Inventor
Дейл ПОРТЕР
Кэролайн Эмери
Луцзянь ТАНЬ
Падмаджа ЙЕРРАМИЛЛИ-РАО
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2015124954A publication Critical patent/RU2015124954A/ru
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Publication of RU2674995C2 publication Critical patent/RU2674995C2/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2015124954A 2012-11-29 2013-11-26 Фармацевтические комбинации RU2674995C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261731174P 2012-11-29 2012-11-29
US61/731,174 2012-11-29
US201261731555P 2012-11-30 2012-11-30
US61/731,555 2012-11-30
US201361755520P 2013-01-23 2013-01-23
US61/755,520 2013-01-23
PCT/US2013/071852 WO2014085381A1 (en) 2012-11-29 2013-11-26 Pharmaceutical combinations

Publications (2)

Publication Number Publication Date
RU2015124954A RU2015124954A (ru) 2017-01-11
RU2674995C2 true RU2674995C2 (ru) 2018-12-14

Family

ID=49753513

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015124954A RU2674995C2 (ru) 2012-11-29 2013-11-26 Фармацевтические комбинации

Country Status (16)

Country Link
US (1) US9446043B2 (cg-RX-API-DMAC7.html)
EP (1) EP2925366B1 (cg-RX-API-DMAC7.html)
JP (1) JP6437444B2 (cg-RX-API-DMAC7.html)
CN (1) CN104812415A (cg-RX-API-DMAC7.html)
AU (1) AU2013352379B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015012497B1 (cg-RX-API-DMAC7.html)
CA (1) CA2892578C (cg-RX-API-DMAC7.html)
DK (1) DK2925366T3 (cg-RX-API-DMAC7.html)
ES (1) ES2669248T3 (cg-RX-API-DMAC7.html)
HU (1) HUE037618T2 (cg-RX-API-DMAC7.html)
NZ (1) NZ708802A (cg-RX-API-DMAC7.html)
PL (1) PL2925366T3 (cg-RX-API-DMAC7.html)
RU (1) RU2674995C2 (cg-RX-API-DMAC7.html)
TR (1) TR201806682T4 (cg-RX-API-DMAC7.html)
UA (1) UA115250C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014085381A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201904851D0 (en) 2019-04-05 2019-05-22 Katholieke Univ Leven Melanoma treatment
US11086278B2 (en) 2019-08-29 2021-08-10 Inventus Holdings, Llc Adaptive system monitoring using incremental regression model development
US20240207257A1 (en) * 2021-04-15 2024-06-27 Ideaya Biosciences, Inc. Combination therapy comprising a pkc inhibitor and a mek inhibitor
WO2024044774A2 (en) * 2022-08-26 2024-02-29 Ideaya Biosciences, Inc. Methods of treating uveal melanoma with a pkc inhibitor
GB202408599D0 (en) * 2024-06-14 2024-07-31 Vasopharma Ab Combination treatments
GB202408598D0 (en) * 2024-06-14 2024-07-31 Edvince Ab Combination treatments

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038561A1 (en) * 2000-11-07 2002-05-16 Novartis Ag Indolylmaleimide derivatives as protein kinase c inhibitors
WO2003077914A1 (en) * 2002-03-13 2003-09-25 Array Biopharma, Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US20050009767A1 (en) * 2003-07-10 2005-01-13 Icn Pharmaceuticals Switzerland Ag Use of ribofuranose derivatives against inflammatory bowel diseases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489608A (en) 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
US5475085A (en) 1991-02-07 1995-12-12 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
PE49195A1 (es) 1993-12-07 1996-01-06 Lilly Co Eli Inhibidor de proteinquinasa
US5545636A (en) 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
EP1449529B1 (en) 1993-12-23 2010-01-27 Eli Lilly And Company Protein Kinase C Inhibitors
ZA969646B (en) 1995-11-20 1998-05-18 Lilly Co Eli Protein kinase C inhibitor.
YU2503A (sh) 2000-07-19 2006-05-25 Warner-Lambert Company Oksigenovani estri 4-jodo fenilamino benzhidroksamskih kiselina
US6645970B2 (en) 2000-11-07 2003-11-11 Novartis Ag Indolylmaleimide derivatives
AR039209A1 (es) 2002-04-03 2005-02-09 Novartis Ag Derivados de indolilmaleimida
RS50569B (sr) 2004-06-11 2010-05-07 Japan Tobacco Inc. Derivati 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2h-pirido (2,3-d)pirimidina i slična jedinjenja za lečenje raka
EP2361905B1 (en) 2005-05-18 2013-03-06 Array Biopharma Inc. Heterocyclic Inhibitors of MEK and methods of use thereof
MX2008000463A (es) 2005-07-11 2008-03-11 Novartis Ag Derivados de indolil-maleimida.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038561A1 (en) * 2000-11-07 2002-05-16 Novartis Ag Indolylmaleimide derivatives as protein kinase c inhibitors
WO2003077914A1 (en) * 2002-03-13 2003-09-25 Array Biopharma, Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US20050009767A1 (en) * 2003-07-10 2005-01-13 Icn Pharmaceuticals Switzerland Ag Use of ribofuranose derivatives against inflammatory bowel diseases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAMPILLO N.E. In silico ADME Approaches // Frontiers in Drug Design & Discovery 4, 2009, стр. 320. PHENEGER J. et al. Characterization of ARRY-438162, a potent MEK inhibitor in combination with Methotreaxate or Ibuprofen in vivo modls of arthritis // American College of Rheumatology, Annual Scientific Meeting, 2006. U0126 Bis[amino[(2-aminophenyl)thio]methylene] butanedinitrile // Life Technolodies, 09.09.2011. Приказ 82 Министерства Здравоохранения Российской Федерации, 29.02.2000, стр. 4. *
WU X. et al. The protein kinase C inhibitor Enzastaurin exhibits antitumor activity against uveal melanoma // PLoS *
WU X. et al. The protein kinase C inhibitor Enzastaurin exhibits antitumor activity against uveal melanoma // PLoS ONE 12.01.2012 *

Also Published As

Publication number Publication date
CA2892578A1 (en) 2014-06-05
US9446043B2 (en) 2016-09-20
JP2016501222A (ja) 2016-01-18
CN104812415A (zh) 2015-07-29
WO2014085381A1 (en) 2014-06-05
DK2925366T3 (en) 2018-06-06
BR112015012497A2 (pt) 2017-07-11
EP2925366A1 (en) 2015-10-07
BR112015012497B1 (pt) 2022-05-17
NZ708802A (en) 2019-09-27
ES2669248T3 (es) 2018-05-24
CA2892578C (en) 2021-01-12
US20150306101A1 (en) 2015-10-29
JP6437444B2 (ja) 2018-12-12
AU2013352379A1 (en) 2015-06-11
RU2015124954A (ru) 2017-01-11
BR112015012497A8 (pt) 2019-10-01
PL2925366T3 (pl) 2018-08-31
HUE037618T2 (hu) 2018-09-28
UA115250C2 (uk) 2017-10-10
TR201806682T4 (tr) 2018-06-21
HK1215789A1 (en) 2016-09-15
EP2925366B1 (en) 2018-02-21
AU2013352379B2 (en) 2018-09-06

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