RU2666349C2 - Новое конденсированное пиримидиновое соединение или его соль - Google Patents

Новое конденсированное пиримидиновое соединение или его соль Download PDF

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Publication number
RU2666349C2
RU2666349C2 RU2015156524A RU2015156524A RU2666349C2 RU 2666349 C2 RU2666349 C2 RU 2666349C2 RU 2015156524 A RU2015156524 A RU 2015156524A RU 2015156524 A RU2015156524 A RU 2015156524A RU 2666349 C2 RU2666349 C2 RU 2666349C2
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Russia
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group
amino
oxazol
carboxamide
pyrazolo
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RU2015156524A
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English (en)
Russian (ru)
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RU2015156524A (ru
Inventor
Сатору Игути
Фумихито ХОСОЙ
Такеси Сагара
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Тайхо Фармасьютикал Ко., Лтд.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
RU2015156524A 2013-08-12 2014-08-11 Новое конденсированное пиримидиновое соединение или его соль RU2666349C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-167600 2013-08-12
JP2013167600 2013-08-12
PCT/JP2014/071158 WO2015022926A1 (ja) 2013-08-12 2014-08-11 新規な縮合ピリミジン化合物又はその塩

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Publication Number Publication Date
RU2015156524A RU2015156524A (ru) 2017-09-14
RU2666349C2 true RU2666349C2 (ru) 2018-09-07

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US (1) US9580432B2 (enExample)
EP (1) EP2947086B1 (enExample)
JP (1) JP6035423B2 (enExample)
KR (1) KR101828187B1 (enExample)
CN (1) CN105452257B (enExample)
AU (1) AU2014307437B2 (enExample)
BR (1) BR112016002069B1 (enExample)
CA (1) CA2921208C (enExample)
DK (1) DK2947086T3 (enExample)
ES (1) ES2661733T3 (enExample)
HU (1) HUE036834T2 (enExample)
MX (1) MX360498B (enExample)
MY (1) MY171831A (enExample)
NO (1) NO2947086T3 (enExample)
PH (1) PH12015502737B1 (enExample)
PL (1) PL2947086T3 (enExample)
PT (1) PT2947086T (enExample)
RU (1) RU2666349C2 (enExample)
SG (1) SG11201600048VA (enExample)
TR (1) TR201802875T4 (enExample)
TW (1) TWI585089B (enExample)
WO (1) WO2015022926A1 (enExample)

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RU2705579C2 (ru) * 2015-09-01 2019-11-08 Тайхо Фармасьютикал Ко., Лтд. Новое пиразоло[3, 4-d]пиримидиновое соединение или его соль

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US20170050936A1 (en) 2013-08-23 2017-02-23 Neupharma, Inc. Certain chemical entities, compositions, and methods
SG11201704431VA (en) 2015-01-30 2017-09-28 Taiho Pharmaceutical Co Ltd Novel salt of fused pyrimidine compound and crystal thereof
CN107206001B (zh) * 2015-01-30 2021-09-28 大鹏药品工业株式会社 免疫疾病的预防剂和/或治疗剂
MA41559A (fr) 2015-09-08 2017-12-26 Taiho Pharmaceutical Co Ltd Composé de pyrimidine condensé ou un sel de celui-ci
TWI642671B (zh) * 2015-10-28 2018-12-01 台灣神隆股份有限公司 依魯替尼之製備方法及其中間體
EP3269370B1 (en) 2016-02-23 2020-01-08 Taiho Pharmaceutical Co., Ltd. Novel condensed pyrimidine compound or salt thereof
EP4006035B1 (en) * 2016-08-15 2023-11-22 Neupharma, Inc. Quinazoline derivatives as tyrosine kinase inhibitors for the treatment of cancer
JP7223684B2 (ja) * 2017-02-28 2023-02-16 大鵬薬品工業株式会社 ピラゾロ［３，４－ｄ］ピリミジン化合物を用いた抗腫瘍効果増強剤
EP3674325A4 (en) 2017-08-21 2021-11-03 Taiho Pharmaceutical Co., Ltd. FUSION PROTEIN OF DCTN1 PROTEIN WITH RET PROTEIN
PL3909584T3 (pl) * 2019-01-11 2024-03-25 Taiho Pharmaceutical Co., Ltd. Związek pirymidynowy lub jego sól
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
US20230064254A1 (en) 2019-12-19 2023-03-02 Taiho Pharmaceutical Co., Ltd. Therapeutic agent containing fused pyrimidine compound as active ingredient
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20230255972A1 (en) * 2020-07-15 2023-08-17 Taiho Pharmaceutical Co., Ltd. Pyrimidine compound-containing combination to be used in tumor treatment
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN114736207B (zh) * 2022-04-28 2023-03-31 武汉九州钰民医药科技有限公司 一种小分子her2抑制剂的制备工艺

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RU2001111034A (ru) * 1998-09-18 2003-05-20 Басф Акциенгезелльшафт 4-аминопирролопиримидины в качестве ингибиторов киназ
WO2008054827A2 (en) * 2006-11-03 2008-05-08 Pharmacyclics, Inc. Bruton's tyrosine kinase activity probe and method of using
WO2009057733A1 (ja) * 2007-10-31 2009-05-07 Santen Pharmaceutical Co., Ltd. 血管新生阻害活性を有する新規インドール誘導体
JP2009518434A (ja) * 2005-12-08 2009-05-07 アボット・ラボラトリーズ タンパク質キナーゼ阻害薬としての９員ヘテロ二環式化合物
WO2013010136A2 (en) * 2011-07-13 2013-01-17 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2013010889A1 (en) * 2011-07-15 2013-01-24 Sanofi-Aventis Deutschland Gmbh A drug delivery device
EA017865B1 (ru) * 2007-03-28 2013-03-29 Фармасайкликс, Инк. Ингибиторы тирозинкиназы брутона

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AU2004285923A1 (en) 2003-10-27 2005-05-12 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
CN101460161A (zh) 2006-03-29 2009-06-17 弗尔德里克斯制药股份有限公司 α-突触核蛋白毒性的抑制
CA3031835C (en) 2008-06-27 2021-09-07 Celgene Car Llc Heteroaryl compounds and uses thereof
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
CN103958512B (zh) 2012-01-19 2016-01-20 大鹏药品工业株式会社 3,5-双取代炔基苯化合物及其盐
CN104250250A (zh) * 2013-06-25 2014-12-31 苏州科捷生物医药有限公司 4-芳香胺基嘧啶类化合物及其抗肿瘤用途

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2001111034A (ru) * 1998-09-18 2003-05-20 Басф Акциенгезелльшафт 4-аминопирролопиримидины в качестве ингибиторов киназ
JP2009518434A (ja) * 2005-12-08 2009-05-07 アボット・ラボラトリーズ タンパク質キナーゼ阻害薬としての９員ヘテロ二環式化合物
WO2008054827A2 (en) * 2006-11-03 2008-05-08 Pharmacyclics, Inc. Bruton's tyrosine kinase activity probe and method of using
EA017865B1 (ru) * 2007-03-28 2013-03-29 Фармасайкликс, Инк. Ингибиторы тирозинкиназы брутона
WO2009057733A1 (ja) * 2007-10-31 2009-05-07 Santen Pharmaceutical Co., Ltd. 血管新生阻害活性を有する新規インドール誘導体
WO2013010136A2 (en) * 2011-07-13 2013-01-17 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2013010889A1 (en) * 2011-07-15 2013-01-24 Sanofi-Aventis Deutschland Gmbh A drug delivery device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2705579C2 (ru) * 2015-09-01 2019-11-08 Тайхо Фармасьютикал Ко., Лтд. Новое пиразоло[3, 4-d]пиримидиновое соединение или его соль

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JP6035423B2 (ja) 2016-11-30
ES2661733T3 (es) 2018-04-03
CA2921208A1 (en) 2015-02-19
KR20160038891A (ko) 2016-04-07
TWI585089B (zh) 2017-06-01
EP2947086B1 (en) 2018-01-03
TR201802875T4 (tr) 2018-03-21
CA2921208C (en) 2018-02-20
MX2016001845A (es) 2016-05-16
NO2947086T3 (enExample) 2018-06-02
RU2015156524A (ru) 2017-09-14
JPWO2015022926A1 (ja) 2017-03-02
PH12015502737B1 (en) 2018-08-31
US9580432B2 (en) 2017-02-28
TW201536786A (zh) 2015-10-01
MX360498B (es) 2018-11-05
BR112016002069A2 (pt) 2017-08-01
MY171831A (en) 2019-11-01
PL2947086T3 (pl) 2018-06-29
DK2947086T3 (en) 2018-03-19
KR101828187B1 (ko) 2018-02-09
PH12015502737A1 (en) 2016-03-07
WO2015022926A1 (ja) 2015-02-19
BR112016002069B1 (pt) 2020-08-18
US20160115168A1 (en) 2016-04-28
CN105452257B (zh) 2017-09-05
AU2014307437A1 (en) 2016-01-21
CN105452257A (zh) 2016-03-30
SG11201600048VA (en) 2016-03-30
HK1217703A1 (zh) 2017-01-20
AU2014307437B2 (en) 2016-12-15
EP2947086A1 (en) 2015-11-25
HUE036834T2 (hu) 2018-08-28
PT2947086T (pt) 2018-03-09
EP2947086A4 (en) 2016-06-22

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