RU2664462C9 - Комбинированная терапия с помощью антитела к CD19 и аналога пурина - Google Patents

Комбинированная терапия с помощью антитела к CD19 и аналога пурина Download PDF

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RU2664462C9
RU2664462C9 RU2014103490A RU2014103490A RU2664462C9 RU 2664462 C9 RU2664462 C9 RU 2664462C9 RU 2014103490 A RU2014103490 A RU 2014103490A RU 2014103490 A RU2014103490 A RU 2014103490A RU 2664462 C9 RU2664462 C9 RU 2664462C9
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lymphoma
seq
sequence
fludarabine
antibody
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RU2014103490A
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Russian (ru)
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RU2664462C2 (ru
RU2014103490A (ru
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Ютта АМЕРСДОРФЕР
Штефан Штайдль
Марк ВИНДЕРЛИХ
Сузанне КРОН
Лиза РОЙКЬЕР
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МорфоСис АГ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
RU2014103490A 2011-08-16 2012-08-14 Комбинированная терапия с помощью антитела к CD19 и аналога пурина RU2664462C9 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161523862P 2011-08-16 2011-08-16
US61/523,862 2011-08-16
EP11177660 2011-08-16
EP11177660.5 2011-08-16
PCT/EP2012/065904 WO2013024095A1 (en) 2011-08-16 2012-08-14 Combination therapy with an anti - cd19 antibody and a purine analog

Publications (3)

Publication Number Publication Date
RU2014103490A RU2014103490A (ru) 2015-09-27
RU2664462C2 RU2664462C2 (ru) 2018-08-17
RU2664462C9 true RU2664462C9 (ru) 2018-09-28

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RU2014103490A RU2664462C9 (ru) 2011-08-16 2012-08-14 Комбинированная терапия с помощью антитела к CD19 и аналога пурина

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US (3) US20140227277A1 (enExample)
EP (2) EP4083071A3 (enExample)
JP (1) JP6114273B2 (enExample)
KR (3) KR102117202B1 (enExample)
CN (1) CN103703027B (enExample)
AU (1) AU2012296905B2 (enExample)
BR (1) BR112013033916B1 (enExample)
CA (1) CA2841738C (enExample)
CY (1) CY1125148T1 (enExample)
DK (1) DK2744826T3 (enExample)
ES (1) ES2909720T3 (enExample)
HR (1) HRP20220224T1 (enExample)
HU (1) HUE058855T2 (enExample)
IL (1) IL230295B (enExample)
LT (1) LT2744826T (enExample)
MX (1) MX353589B (enExample)
PL (1) PL2744826T3 (enExample)
PT (1) PT2744826T (enExample)
RS (1) RS63121B1 (enExample)
RU (1) RU2664462C9 (enExample)
SG (1) SG10201606788VA (enExample)
SI (1) SI2744826T1 (enExample)
SM (1) SMT202200160T1 (enExample)
WO (1) WO2013024095A1 (enExample)
ZA (1) ZA201401835B (enExample)

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GB2514591A (en) * 2013-05-30 2014-12-03 Mologen Ag Predictive biomarker for cancer therapy
ES2523901B1 (es) * 2013-05-31 2015-12-02 Universidad Autónoma de Madrid Uso de la deguelina como terapia suplementaria de la leucemia linfoide crónica
IL249533A0 (en) * 2014-06-16 2017-02-28 Xencor Inc Treatment of chronic lymphocytic leukemia
EP3157553A4 (en) * 2014-06-16 2018-02-28 Xencor, Inc. Treatment for chronic lymphocytic leukemia (cll)
EP3603672B1 (en) * 2015-05-26 2026-04-22 Incyte Corporation Combination of an anti-cd19 antibody and a bruton's tyrosine kinase inhibitor and uses thereof
MX392561B (es) * 2015-08-21 2025-03-24 Morphosys Ag Combinación sinérgica de un anticuerpo anti-cd19 y un inhibidor de fosfoinositida 3-quinasa para usarse en el tratamiento de linfoma no hodgkin, leucemia linfocítica crónica y/o leucemia linfoblástica aguda.
CN115932265B (zh) * 2016-05-30 2026-04-14 因塞特公司 预测cd19抗体治疗在患者中的治疗益处的方法
KR20230028571A (ko) 2016-10-28 2023-02-28 모르포시스 아게 항-cd19 항체 및 bcl-2 억제제의 조합 및 이의 용도
IL297461B2 (en) * 2017-05-31 2024-09-01 Morphosys Ag Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment
EP3652206A1 (en) 2017-07-10 2020-05-20 International-Drug-Development-Biotech Treatment of b cell malignancies using afucosylated pro-apoptotic anti-cd19 antibodies in combination with anti cd20 antibodies or chemotherapeutics
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
WO2020150513A1 (en) * 2019-01-17 2020-07-23 Fred Hutchinson Cancer Research Center Methods to enhance the selectivity and effectiveness of cancer treatments
CN119013293A (zh) * 2021-12-22 2024-11-22 因赛特公司 抗cd19抗体疗法的治疗范例
IL325762A (en) 2023-07-13 2026-03-01 Christian Albrechts Universit?T Zu Kiel Human anti-CD7 antibody

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US20100272723A1 (en) * 2006-08-14 2010-10-28 Xencor, Inc. Optimized Antibodies that Target CD19
US20110165152A1 (en) * 2009-08-14 2011-07-07 Martin Dreyling Combination therapy of an afucosylated cd20 antibody with fludarabine and/or mitoxantrone

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US20100272723A1 (en) * 2006-08-14 2010-10-28 Xencor, Inc. Optimized Antibodies that Target CD19
US20110165152A1 (en) * 2009-08-14 2011-07-07 Martin Dreyling Combination therapy of an afucosylated cd20 antibody with fludarabine and/or mitoxantrone

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Publication number Publication date
AU2012296905B2 (en) 2017-01-05
ES2909720T3 (es) 2022-05-10
RU2664462C2 (ru) 2018-08-17
EP2744826A1 (en) 2014-06-25
MX2013014935A (es) 2014-07-09
SG10201606788VA (en) 2016-09-29
US20200352975A1 (en) 2020-11-12
JP2014525925A (ja) 2014-10-02
US20140227277A1 (en) 2014-08-14
HRP20220224T1 (hr) 2022-04-29
EP4083071A2 (en) 2022-11-02
KR102117202B1 (ko) 2020-06-01
KR20200060779A (ko) 2020-06-01
JP6114273B2 (ja) 2017-04-12
ZA201401835B (en) 2015-06-24
US20240424012A1 (en) 2024-12-26
PT2744826T (pt) 2022-05-19
SI2744826T1 (sl) 2022-05-31
RU2014103490A (ru) 2015-09-27
CN103703027A (zh) 2014-04-02
EP4083071A3 (en) 2023-02-22
KR20140071368A (ko) 2014-06-11
HUE058855T2 (hu) 2022-09-28
EP2744826B1 (en) 2022-02-09
PL2744826T3 (pl) 2022-05-30
CA2841738C (en) 2022-12-06
NZ617771A (en) 2016-01-29
SMT202200160T1 (it) 2022-05-12
CA2841738A1 (en) 2013-02-21
DK2744826T3 (da) 2022-03-28
RS63121B1 (sr) 2022-05-31
WO2013024095A1 (en) 2013-02-21
MX353589B (es) 2018-01-19
KR20190094478A (ko) 2019-08-13
CN103703027B (zh) 2018-01-12
IL230295B (en) 2018-03-29
BR112013033916B1 (pt) 2022-11-16
LT2744826T (lt) 2022-04-25
BR112013033916A2 (pt) 2017-11-28
CY1125148T1 (el) 2024-12-13

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