RU2652304C2 - Способ прогнозирования риска развития сердечно-сосудистой патологии у особи женского пола - Google Patents
Способ прогнозирования риска развития сердечно-сосудистой патологии у особи женского пола Download PDFInfo
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| PCT/EP2013/054799 WO2013132088A1 (en) | 2012-03-08 | 2013-03-08 | A method for predicting the risk of getting a cardiovascular event in a female subject |
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| RU2718285C1 (ru) * | 2019-05-31 | 2020-04-01 | федеральное государственное бюджетное образовательное учреждение высшего образования "Новосибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НГМУ Минздрава России) | Способ прогнозирования риска развития инсульта у мужчин, работающих в условиях воздействия общей вибрации |
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| EP3002589A1 (en) * | 2014-10-01 | 2016-04-06 | sphingotec GmbH | A method for stratifying a female subject for hormone replacement therapy |
| CA2977494A1 (en) * | 2015-02-27 | 2016-05-06 | Sphingotec Gmbh | A method for predicting the risk of obesity in a subject |
| SG11202002391PA (en) * | 2017-10-24 | 2020-04-29 | Sphingotec Gmbh | Selenoprotein p for prediction of a first cardiovascular event |
| CN109678958B (zh) * | 2019-01-31 | 2022-03-18 | 重庆探生科技有限公司 | 一种人NT-proBNP特异性重组羊单克隆抗体及其制备方法和应用 |
| WO2022101937A1 (en) * | 2020-11-12 | 2022-05-19 | Shah Komal | An integrated health data capture and analysis based device for evaluation, diagnosis and prognosis of heart failure |
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| US20050130230A1 (en) * | 2003-09-23 | 2005-06-16 | Antoni Davalos | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| WO2010128071A1 (en) * | 2009-05-05 | 2010-11-11 | Brahms Ag | Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction |
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| AU634716B2 (en) | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
| US6352862B1 (en) * | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| CA2228970A1 (en) * | 1995-08-18 | 1997-02-27 | Donald W. Landry | Detection of organic compounds through regulation of antibody-catalyzed reactions |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US7427490B2 (en) * | 2001-08-20 | 2008-09-23 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| MXPA04001804A (es) | 2001-08-30 | 2005-03-07 | Biorexis Pharmaceutical Corp | Proteinas de fusion de transferrina modificada. |
| DK2298278T3 (en) | 2002-06-07 | 2016-02-01 | Dyax Corp | Prevention and reduction of blood loss and inflammatory response |
| EP1675878A2 (en) | 2003-10-24 | 2006-07-05 | Avidia, Inc. | Ldl receptor class a and egf domain monomers and multimers |
| US20100028995A1 (en) | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
| ES2421556T3 (es) * | 2004-06-15 | 2013-09-03 | Hoffmann La Roche | Utilización de hormonas cardíacas para diagnosticar el riesgo de sufrir complicaciones cardiovasculares como consecuencia de medicamentos cardiotóxicos |
| CA2580881A1 (en) | 2004-09-21 | 2006-03-30 | Nascacell Technologies Ag | Use of microproteins as tryptase inhibitors |
| DE102005003687A1 (de) * | 2005-01-26 | 2006-07-27 | Sphingo Tec Gmbh | Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation |
| EP2231860B1 (en) | 2007-12-19 | 2011-10-05 | Affibody AB | Polypeptide derived from protein a and able to bind pdgf |
| CA2742241C (en) | 2008-11-03 | 2019-12-10 | Molecular Partners Ag | Binding proteins inhibiting the vegf-a receptor interaction |
| ES2538002T3 (es) | 2009-01-07 | 2015-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Métodos para el tratamiento, la evaluación pronóstica y la detección de cáncer de mama |
| CN102869678A (zh) | 2009-08-27 | 2013-01-09 | 科瓦根股份公司 | Il-17结合化合物及其医药用途 |
| US8846414B2 (en) * | 2009-09-29 | 2014-09-30 | Advanced Liquid Logic, Inc. | Detection of cardiac markers on a droplet actuator |
| WO2011073214A2 (en) | 2009-12-14 | 2011-06-23 | Scil Proteins Gmbh | A method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands |
| RS58839B1 (sr) | 2010-06-08 | 2019-07-31 | Pieris Pharmaceuticals Gmbh | Muteini lipokalina u suzama koji vezuju il-4 r alfa |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050130230A1 (en) * | 2003-09-23 | 2005-06-16 | Antoni Davalos | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| WO2010128071A1 (en) * | 2009-05-05 | 2010-11-11 | Brahms Ag | Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction |
Non-Patent Citations (3)
| Title |
|---|
| ERNST A., HELLMICH S., BERGMANN A. Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation // Peptides. 2006. Vol.27, P.1787 - 1793. * |
| ERNST A., HELLMICH S., BERGMANN A. Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation // Peptides. 2006. Vol.27, P.1787 - 1793. MELANDER O. et al. Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community // JAMA. 2009. Vol.302, No.1, P.49-57. * |
| MELANDER O. et al. Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community // JAMA. 2009. Vol.302, No.1, P.49-57. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718285C1 (ru) * | 2019-05-31 | 2020-04-01 | федеральное государственное бюджетное образовательное учреждение высшего образования "Новосибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НГМУ Минздрава России) | Способ прогнозирования риска развития инсульта у мужчин, работающих в условиях воздействия общей вибрации |
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| Publication number | Publication date |
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| WO2013132088A1 (en) | 2013-09-12 |
| JP6431373B2 (ja) | 2018-11-28 |
| JP2015511007A (ja) | 2015-04-13 |
| IN2014MN01940A (esLanguage) | 2015-07-10 |
| CN103308673A (zh) | 2013-09-18 |
| RU2014140430A (ru) | 2016-04-27 |
| EP2823318A1 (en) | 2015-01-14 |
| EP2823318B1 (en) | 2016-08-10 |
| WO2013132088A4 (en) | 2013-11-07 |
| CN103308673B (zh) | 2017-05-31 |
| US20150118236A1 (en) | 2015-04-30 |
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