RU2641593C2 - Композиции и способы лечения кариеса зубов - Google Patents
Композиции и способы лечения кариеса зубов Download PDFInfo
- Publication number
- RU2641593C2 RU2641593C2 RU2015120957A RU2015120957A RU2641593C2 RU 2641593 C2 RU2641593 C2 RU 2641593C2 RU 2015120957 A RU2015120957 A RU 2015120957A RU 2015120957 A RU2015120957 A RU 2015120957A RU 2641593 C2 RU2641593 C2 RU 2641593C2
- Authority
- RU
- Russia
- Prior art keywords
- composition
- arginine
- bisabolol
- composition according
- fluoride
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 123
- 238000000034 method Methods 0.000 title claims abstract description 21
- 208000002925 dental caries Diseases 0.000 title claims abstract description 16
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 36
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 34
- 239000004475 Arginine Substances 0.000 claims abstract description 32
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 32
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 31
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229940036350 bisabolol Drugs 0.000 claims abstract description 30
- 210000000214 mouth Anatomy 0.000 claims abstract description 29
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 150000001413 amino acids Chemical class 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 229930004725 sesquiterpene Natural products 0.000 claims abstract description 14
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims abstract description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 42
- -1 fluoride ions Chemical class 0.000 claims description 36
- 235000009697 arginine Nutrition 0.000 claims description 29
- 235000001014 amino acid Nutrition 0.000 claims description 21
- 239000000377 silicon dioxide Substances 0.000 claims description 20
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 16
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- 239000002245 particle Substances 0.000 claims description 8
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- 239000003945 anionic surfactant Substances 0.000 claims description 7
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 6
- 229930064664 L-arginine Natural products 0.000 claims description 6
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- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 5
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- 239000001506 calcium phosphate Substances 0.000 claims description 4
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- 235000013024 sodium fluoride Nutrition 0.000 claims description 4
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- DAOANAATJZWTSJ-UHFFFAOYSA-N N-Decanoylmorpholine Chemical compound CCCCCCCCCC(=O)N1CCOCC1 DAOANAATJZWTSJ-UHFFFAOYSA-N 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
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- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims description 2
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 claims description 2
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 2
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- 239000003002 pH adjusting agent Substances 0.000 claims 2
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims 1
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- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 claims 1
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/067547 WO2014088535A1 (en) | 2012-12-03 | 2012-12-03 | Compositions and methods for treating dental caries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015120957A RU2015120957A (ru) | 2017-01-11 |
| RU2641593C2 true RU2641593C2 (ru) | 2018-01-18 |
Family
ID=47521147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015120957A RU2641593C2 (ru) | 2012-12-03 | 2012-12-03 | Композиции и способы лечения кариеса зубов |
Country Status (17)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2812887C1 (ru) * | 2023-10-10 | 2024-02-05 | Общество с ограниченной ответственностью "Ваш личный доктор" | Способ лечения кариеса дентина |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015369930B2 (en) * | 2014-12-23 | 2018-10-18 | Colgate-Palmolive Company | Oral care composition |
| WO2017214497A1 (en) | 2016-06-10 | 2017-12-14 | Clarity Cosmetics Inc. | Non-comedogenic hair and scalp care formulations and method for use |
| WO2019222126A1 (en) * | 2018-05-14 | 2019-11-21 | The Procter & Gamble Company | Oral care compositions comprising metal ions |
| TWI707294B (zh) * | 2019-12-05 | 2020-10-11 | 國立聯合大學 | 田間湛水感測裝置、田間湛水感測系統、及田間湛水感測方法 |
| EP4014948A1 (de) * | 2020-12-18 | 2022-06-22 | Ivoclar Vivadent AG | Zusammensetzung zur remineralisation von zähnen |
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2012
- 2012-12-03 WO PCT/US2012/067547 patent/WO2014088535A1/en active Application Filing
- 2012-12-03 IN IN4074DEN2015 patent/IN2015DN04074A/en unknown
- 2012-12-03 JP JP2015545018A patent/JP2016501217A/ja active Pending
- 2012-12-03 AU AU2012396257A patent/AU2012396257B2/en active Active
- 2012-12-03 MX MX2015006914A patent/MX351254B/es active IP Right Grant
- 2012-12-03 BR BR112015012824-6A patent/BR112015012824B1/pt active IP Right Grant
- 2012-12-03 RU RU2015120957A patent/RU2641593C2/ru active
- 2012-12-03 CN CN201280077477.9A patent/CN104822422B/zh active Active
- 2012-12-03 KR KR1020157016317A patent/KR20150090136A/ko not_active Withdrawn
- 2012-12-03 CA CA2891204A patent/CA2891204C/en active Active
- 2012-12-03 EP EP12812760.2A patent/EP2925412B1/en active Active
- 2012-12-03 US US14/649,136 patent/US9526681B2/en active Active
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2013
- 2013-11-20 TW TW102142174A patent/TWI519315B/zh not_active IP Right Cessation
- 2013-12-03 AR ARP130104471A patent/AR093717A1/es unknown
-
2015
- 2015-05-14 IL IL238846A patent/IL238846B/en active IP Right Grant
- 2015-05-28 ZA ZA2015/03844A patent/ZA201503844B/en unknown
- 2015-06-03 PH PH12015501251A patent/PH12015501251A1/en unknown
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| EP0348560A1 (en) * | 1987-05-11 | 1990-01-03 | Lion Corporation | Oral composition |
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|---|---|---|---|---|
| RU2812887C1 (ru) * | 2023-10-10 | 2024-02-05 | Общество с ограниченной ответственностью "Ваш личный доктор" | Способ лечения кариеса дентина |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014088535A1 (en) | 2014-06-12 |
| CN104822422B (zh) | 2018-03-13 |
| IL238846A0 (en) | 2015-06-30 |
| EP2925412B1 (en) | 2017-07-26 |
| TWI519315B (zh) | 2016-02-01 |
| KR20150090136A (ko) | 2015-08-05 |
| TW201434486A (zh) | 2014-09-16 |
| AU2012396257B2 (en) | 2015-10-08 |
| MX2015006914A (es) | 2015-09-08 |
| PH12015501251A1 (en) | 2015-08-17 |
| AU2012396257A1 (en) | 2015-05-28 |
| US20150335551A1 (en) | 2015-11-26 |
| CA2891204C (en) | 2020-07-07 |
| AR093717A1 (es) | 2015-06-17 |
| IN2015DN04074A (enrdf_load_stackoverflow) | 2015-10-09 |
| BR112015012824B1 (pt) | 2018-08-07 |
| RU2015120957A (ru) | 2017-01-11 |
| CN104822422A (zh) | 2015-08-05 |
| MX351254B (es) | 2017-10-06 |
| CA2891204A1 (en) | 2014-06-12 |
| EP2925412A1 (en) | 2015-10-07 |
| US9526681B2 (en) | 2016-12-27 |
| ZA201503844B (en) | 2017-11-29 |
| JP2016501217A (ja) | 2016-01-18 |
| IL238846B (en) | 2019-07-31 |
| BR112015012824A2 (pt) | 2017-07-11 |
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