RU2637441C2 - Репрограммирование эффекторных белковых взаимодействий для исправления эпигенетических дефектов в злокачественной опухоли - Google Patents

Репрограммирование эффекторных белковых взаимодействий для исправления эпигенетических дефектов в злокачественной опухоли Download PDF

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RU2637441C2
RU2637441C2 RU2014138543A RU2014138543A RU2637441C2 RU 2637441 C2 RU2637441 C2 RU 2637441C2 RU 2014138543 A RU2014138543 A RU 2014138543A RU 2014138543 A RU2014138543 A RU 2014138543A RU 2637441 C2 RU2637441 C2 RU 2637441C2
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histone
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Стивен Дж. М. ДЖОУНС
Олександр ЯКОВЕНКО
Сильвия ТОЕН
Пьер Юлминь ЧЭУН
Цзяньхун АНЬ
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Бритиш Коламбиа Кансер Эдженси Бранч
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RU2014138543A 2012-02-27 2013-02-27 Репрограммирование эффекторных белковых взаимодействий для исправления эпигенетических дефектов в злокачественной опухоли RU2637441C2 (ru)

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US201261603650P 2012-02-27 2012-02-27
US61/603,650 2012-02-27
US201261637282P 2012-04-24 2012-04-24
US61/637,282 2012-04-24
PCT/CA2013/050145 WO2013127011A1 (en) 2012-02-27 2013-02-27 Reprogramming effector protein interactions to correct epigenetic defects in cancer

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RU2637441C2 true RU2637441C2 (ru) 2017-12-04

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EP (1) EP2819662B1 (OSRAM)
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CN (1) CN104136020B (OSRAM)
AU (1) AU2013225592B2 (OSRAM)
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Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
AU2014233198B2 (en) * 2013-03-15 2019-06-27 Sutter West Bay Hospitals Falz for use as a target for therapies to treat cancer
AU2014316783A1 (en) * 2013-09-09 2016-04-28 Glionova Ab Compounds and use for treating cancer
EP3064205A1 (en) * 2015-03-06 2016-09-07 Glionova AB Therapeutic use of isomeric forms of 2-(4-chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol
EP3271485A4 (en) * 2015-03-18 2019-01-16 Memorial Sloan-Kettering Cancer Center METHOD FOR DIAGNOSIS AND TREATMENT OF FOLLICULAR LYMPHOMA
JP6862418B2 (ja) 2015-07-31 2021-04-21 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング センサ、カートリッジ、および薬物送達デバイス
JP2021501198A (ja) * 2017-10-27 2021-01-14 トランスフュージョン ヘルス,リミティド ライアビリティ カンパニー フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法
US20230395185A1 (en) * 2020-10-14 2023-12-07 The Regents Of The University Of California Systems for and methods of determining protein-protein interaction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009015283A2 (en) * 2007-07-24 2009-01-29 President And Fellows Of Harvard College Bhc80 - histone complexes and uses thereof
WO2011143669A2 (en) * 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc Compositions and methods for treating neoplasia, inflammatory disease and other disorders

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL263904A (OSRAM) * 1960-04-26
GB1120461A (en) * 1964-07-06 1968-07-17 Manuf Prod Pharma Derivatives of fluoreno-[1,9-ef]1,4-diazepine-1-oxide
US3622580A (en) * 1969-03-25 1971-11-23 Smith Kline French Lab Piperazino-acetylamino-9-fluorenones and-anthraquinones
LU85246A1 (fr) * 1984-03-13 1985-10-14 R L Galephar Sa 2-(aminoalkyl)acrylophenones,leur preparation et leur utilisation
US5501959A (en) 1989-01-17 1996-03-26 Alamar Biosciences Laboratory, Inc. Antibiotic and cytotoxic drug susceptibility assays using resazurin and poising agents
WO2000011206A1 (en) * 1998-08-25 2000-03-02 The Scripps Research Institute Methods and systems for predicting protein function
US7928218B2 (en) 2002-02-20 2011-04-19 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
JP5682051B2 (ja) * 2006-05-18 2015-03-11 ファーマサイクリックス,インク. 細胞内キナーゼ阻害剤
CN102369204A (zh) 2008-09-26 2012-03-07 新加坡科技研究局 3-脱氮瓶菌素衍生物
WO2010045199A2 (en) * 2008-10-13 2010-04-22 University Of South Florida Method of modulating ship activity
GB0822248D0 (en) * 2008-12-05 2009-01-14 Medical Res Council Crystal meths
WO2010094009A2 (en) * 2009-02-13 2010-08-19 Children's Hospital Medical Center Methods and compositions for the treatment of ras associated disorders
WO2011014825A2 (en) * 2009-07-31 2011-02-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antiangiogenic small molecules and methods of use
WO2011103016A2 (en) 2010-02-19 2011-08-25 The Regents Of The University Of Michigan Compositions and methods for inhibiting ezh2
RU2618475C2 (ru) 2010-09-10 2017-05-03 Эпизайм, Инк. Ингибиторы ezh2 человека и способы их применения
WO2012071469A2 (en) 2010-11-23 2012-05-31 Nevada Cancer Institute Histone demethylase inhibitors and uses thereof for treatment o f cancer
EP2677865A4 (en) 2011-02-23 2015-04-22 Icahn School Med Mount Sinai BROMODOMAIN INHIBITORS AS MODULATORS OF GENE EXPRESSION
WO2012123119A1 (en) 2011-03-17 2012-09-20 Cellzome Ag Methods for the identification and characterization of proteins interacting with histone tails and of compounds interacting with said proteins
WO2013059944A1 (en) 2011-10-28 2013-05-02 British Columbia Cancer Agency Branch Epigenetic regulators and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009015283A2 (en) * 2007-07-24 2009-01-29 President And Fellows Of Harvard College Bhc80 - histone complexes and uses thereof
WO2011143669A2 (en) * 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc Compositions and methods for treating neoplasia, inflammatory disease and other disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Kaustov L. et al. Recognition and Specificity Determinants of the Human Cbx Chromodomains. Journal of biological chemistry. January 7, 2011, Volume 286, Number 1, с. 521-529. *
Kaustov L. et al. Recognition and Specificity Determinants of the Human Cbx Chromodomains. Journal of biological chemistry. January 7, 2011, Volume 286, Number 1, с. 521-529. Li H. et al. Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell. 2007 Nov 30; 28(4): 677-91. *
Li H. et al. Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell. 2007 Nov 30; 28(4): 677-91. *

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WO2013127011A1 (en) 2013-09-06
US20150154345A1 (en) 2015-06-04
US9552457B2 (en) 2017-01-24
AU2013225592B2 (en) 2017-11-09
EP2819662A1 (en) 2015-01-07
KR102149860B1 (ko) 2020-08-31
CA2865675A1 (en) 2013-09-06
AU2013225592A2 (en) 2014-10-09
CN104136020B (zh) 2018-08-28
AU2013225592A1 (en) 2014-10-09
JP2015515448A (ja) 2015-05-28
BR112014021201A2 (pt) 2021-06-08
EP2819662A4 (en) 2016-03-23
JP6137703B2 (ja) 2017-05-31
CN104136020A (zh) 2014-11-05
CA2865675C (en) 2023-02-28
RU2014138543A (ru) 2016-04-20
EP2819662B1 (en) 2019-04-10
KR20140132382A (ko) 2014-11-17
IN2014DN07812A (OSRAM) 2015-05-15

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