RU2611396C2 - Способ совместного кондиционирования и хемоселекции за один цикл - Google Patents
Способ совместного кондиционирования и хемоселекции за один цикл Download PDFInfo
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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| US201161477440P | 2011-04-20 | 2011-04-20 | |
| US61/477,440 | 2011-04-20 | ||
| PCT/US2012/034586 WO2012145723A1 (en) | 2011-04-20 | 2012-04-20 | Method for combined conditioning and chemoselection in a single cycle |
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| RU2017104621A Division RU2728867C2 (ru) | 2011-04-20 | 2012-04-20 | Способ совместного кондиционирования и хемоселекции за один цикл |
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| RU2013151632A RU2013151632A (ru) | 2015-05-27 |
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| AU2012245269B2 (en) * | 2011-04-20 | 2016-09-29 | The Regents Of The University Of California | Method for combined conditioning and chemoselection in a single cycle |
| US9682106B2 (en) * | 2011-04-20 | 2017-06-20 | The Regents Of The University Of California | Method for combined conditioning and chemoselection in a single cycle |
| ES2909662T3 (es) * | 2014-08-07 | 2022-05-09 | Laevoroc Immunology Ag | Composiciones que comprenden un inhibidor de PNP para uso en el tratamiento de la recaída de malignidad después de un trasplante de células madre hematopoyéticas |
| US20180140606A1 (en) * | 2016-11-18 | 2018-05-24 | Calimmune, Inc. | In Vivo Chemoselection with Low Dose Thioguanine |
| JP6783674B2 (ja) | 2017-01-20 | 2020-11-11 | 株式会社日立ハイテク | 自動分析装置、自動分析装置における廃液方法、及び、三方電磁弁 |
| WO2019018383A1 (en) * | 2017-07-18 | 2019-01-24 | Calimmune, Inc. | COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES |
| CN111343996A (zh) | 2017-07-18 | 2020-06-26 | 卡利门股份有限公司 | 用于选择供体修饰细胞的可调节开关 |
| US12359200B2 (en) | 2017-10-09 | 2025-07-15 | Stowers Institute For Medical Research | Methods and compositions for expansion of cell population |
| JP2022514955A (ja) * | 2018-12-23 | 2022-02-16 | シーエスエル・ベーリング・エルエルシー | ウィスコット・アルドリッチ症候群の造血幹細胞遺伝子治療 |
| BR112021012318A2 (pt) * | 2018-12-23 | 2022-01-18 | Csl Behring Llc | Células t doadoras com interruptor de eliminação |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997043900A1 (en) * | 1996-05-24 | 1997-11-27 | The President And Fellows Of Harvard College | In vivo selection |
| WO1999025367A2 (en) * | 1997-11-14 | 1999-05-27 | The General Hospital Corporation | Treatment of hematologic disorders |
| US20030032003A1 (en) * | 2000-02-02 | 2003-02-13 | Schiestl Robert H. | In vivo selection |
| US20030073649A1 (en) * | 2001-10-12 | 2003-04-17 | Dimartino Jorge | Composition and method for treating graft-versus-host disease |
| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
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|---|---|---|---|---|
| US5965126A (en) | 1996-03-25 | 1999-10-12 | The Penn State Research Foundation | use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents |
| WO1998019540A1 (en) | 1996-11-04 | 1998-05-14 | Saint Jude Children's Research Hospital | In vivo selection of primitive hematopoietic cells |
| GB9904281D0 (en) * | 1999-02-24 | 1999-04-21 | Reneuron Ltd | Transplantation |
| CA2428721A1 (en) * | 2000-11-14 | 2002-05-23 | The General Hospital Corporation | Blockade of t cell migration into epithelial gvhd target tissues |
| AU2012245269B2 (en) * | 2011-04-20 | 2016-09-29 | The Regents Of The University Of California | Method for combined conditioning and chemoselection in a single cycle |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997043900A1 (en) * | 1996-05-24 | 1997-11-27 | The President And Fellows Of Harvard College | In vivo selection |
| WO1999025367A2 (en) * | 1997-11-14 | 1999-05-27 | The General Hospital Corporation | Treatment of hematologic disorders |
| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| US20030032003A1 (en) * | 2000-02-02 | 2003-02-13 | Schiestl Robert H. | In vivo selection |
| US20030073649A1 (en) * | 2001-10-12 | 2003-04-17 | Dimartino Jorge | Composition and method for treating graft-versus-host disease |
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