RU2607458C2 - Композиция для головного мозга и/или познавательного и/или психомоторного развития - Google Patents
Композиция для головного мозга и/или познавательного и/или психомоторного развития Download PDFInfo
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- RU2607458C2 RU2607458C2 RU2014119844A RU2014119844A RU2607458C2 RU 2607458 C2 RU2607458 C2 RU 2607458C2 RU 2014119844 A RU2014119844 A RU 2014119844A RU 2014119844 A RU2014119844 A RU 2014119844A RU 2607458 C2 RU2607458 C2 RU 2607458C2
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- oligosaccharide
- 4glc
- galβ1
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| EP3248605A1 (en) | 2009-07-06 | 2017-11-29 | Children's Hospital Medical Center | Inhibiting inflammation with milk oligosaccharides |
| DK2708145T3 (en) | 2012-09-14 | 2016-07-18 | Abbott Lab | Nutritional Compositions for Use in Methods to Modulate Corticosterone Levels in Psychologically Stressed Individuals |
| EP3704957A1 (en) | 2012-09-14 | 2020-09-09 | Abbott Laboratories | Methods for increasing brain functionality using 2-fucosyl-lactose |
| EP2880993A1 (en) * | 2013-12-04 | 2015-06-10 | Abbott Laboratories | Method of achieving memory and learning improvement by the administration of sialic acid |
| EP3082473A2 (en) * | 2013-12-19 | 2016-10-26 | Nestec S.A. | Nutritional composition to reduce metabolic stress in infants |
| US20150305385A1 (en) * | 2014-04-25 | 2015-10-29 | Mead Johnson Nutrition Company | Pediatric nutritional composition with human milk oligosaccahrides, prebiotics and probiotics |
| FR3020949B1 (fr) * | 2014-05-16 | 2018-02-09 | Ecole Normale Superieure De Lyon | Composition permettant de favoriser la croissance juvenile humaine et animale en cas de malnutrition |
| EP3212012A1 (en) * | 2014-10-31 | 2017-09-06 | Nestec S.A. | Composition comprising fut2-dependent oligosaccharides and lacto-n-neotetraose for use in promoting brain development and cognition |
| CN106998775A (zh) * | 2014-11-26 | 2017-08-01 | 雅培制药有限公司 | 具有RRR‑α‑生育酚、2’‑岩藻糖基乳糖和益生菌的婴儿配方 |
| WO2016145628A1 (en) * | 2015-03-18 | 2016-09-22 | Nestec S.A. | Composition comprising siallyllactose for use in enhancing learning skills and memory function |
| WO2016176484A1 (en) | 2015-04-28 | 2016-11-03 | Children's Hospital Medical Center | Use of oligosaccharide compositions to enhance weight gain |
| CN107847509B (zh) * | 2015-08-04 | 2021-06-01 | 雀巢产品有限公司 | 具有2FL和LNnT的营养组合物 |
| ES2759556T3 (es) | 2015-12-15 | 2020-05-11 | Nestle Sa | Mezcla de oligosacáricos de la leche humana |
| US20210205340A1 (en) * | 2016-01-26 | 2021-07-08 | Nestec S.A. | Compositions comprising sialylated oligosaccharides for use in infants or young children to prevent later in life obesity or related comorbidities and promote a healthy growth |
| RU2735250C2 (ru) * | 2016-01-26 | 2020-10-29 | Сосьете Де Продюи Нестле С.А. | КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ 2FL И LNnT, ДЛЯ КОНТРОЛЯ ПОТРЕБЛЕНИЯ ПИЩИ И РОСТА У МЛАДЕНЦЕВ ИЛИ ДЕТЕЙ МЛАДШЕГО ВОЗРАСТА |
| EP3443969B1 (en) * | 2016-04-13 | 2021-12-22 | Meiji Co., Ltd. | Use of bifidobacteria for improving developmental quotient in neonates |
| CN109715169A (zh) | 2016-07-28 | 2019-05-03 | 方塔拉合作集团有限公司 | 乳制品和工艺 |
| EP3565421A4 (en) | 2017-05-04 | 2020-07-22 | The Board of Trustees of the Leland Stanford Junior University | FOOD COMPOSITIONS PROMOTING NEUROLOGICAL DEVELOPMENT AND ASSOCIATED KITS, SYSTEMS AND PROCESSES |
| EP3624786B1 (en) | 2017-05-16 | 2023-07-05 | Ability Pharmaceuticals S.L. | A pharmaceutical combination for the treatment of a cancer |
| WO2018215406A1 (en) * | 2017-05-24 | 2018-11-29 | Nestec S.A. | A nutritional composition for use to enhance attention and/or reduce impulsivity |
| WO2019008104A1 (en) * | 2017-07-07 | 2019-01-10 | Nestec S.A. | FORTIFYING HUMAN MILK |
| WO2019008105A1 (en) * | 2017-07-07 | 2019-01-10 | Nestec S.A. | FORTIFYING HUMAN MILK |
| RU2698564C1 (ru) * | 2019-01-09 | 2019-08-28 | Федеральное государственное бюджетное учреждение "Уральский научно-исследовательский институт охраны материнства и младенчества" Министерства здравоохранения Российской Федерации (ФГБУ "НИИ ОММ" Минздрава России) | Способ прогнозирования риска развития гипотрофии у детей, родившихся в сроке сверхранних преждевременных родов, к скорригированному возрасту 6 месяцев |
| WO2022117710A1 (en) | 2020-12-04 | 2022-06-09 | Société des Produits Nestlé S.A. | Stable aqueous composition for preterm to promote early postnal growth |
| KR102570073B1 (ko) * | 2022-11-17 | 2023-08-24 | (주)에이피테크놀로지 | 2'-푸코실락토오스를 포함하는 치매 개선 또는 치료용조성물 |
| CN118285505A (zh) * | 2024-03-29 | 2024-07-05 | 黑龙江飞鹤乳业有限公司 | 促进大脑发育的营养组合物、食品及配方奶粉 |
| WO2025257135A1 (en) | 2024-06-10 | 2025-12-18 | N.V. Nutricia | Non-digestible oligosaccharide mixture for infants at risk of brain injury |
Citations (4)
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|---|---|---|---|---|
| EP2258216A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
| EP2272381A2 (en) * | 2007-11-26 | 2011-01-12 | Nestec S.A. | Age-tailored nutrition system for infants |
| WO2011012655A1 (en) * | 2009-07-31 | 2011-02-03 | Nestec S.A. | Nutritional composition for breast-fed infants or pets with probiotics and selected nutrients |
| RU2430631C2 (ru) * | 2006-02-10 | 2011-10-10 | Нестек С.А. | Пребиотическая смесь олигосахаридов и пищевой продукт, ее содержащий |
Family Cites Families (15)
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| EP0481038B1 (en) | 1990-04-16 | 2002-10-02 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| US5545553A (en) | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
| US20040048926A1 (en) * | 2002-03-15 | 2004-03-11 | Hoffman Dennis Robert | Use of docosahexaenoic acid and arachidonic acid to enhance the visual development of term infants breast-fed up to the age of six months |
| PT1638416E (pt) * | 2003-06-23 | 2013-07-08 | Nestec Sa | Utilização de uma fórmula nutricional para função de barreira intestinal óptima |
| CA2532489C (en) * | 2003-06-23 | 2012-12-11 | Nestec S.A. | Infant or follow-on formula |
| DE602004006133T3 (de) * | 2003-06-30 | 2014-12-24 | Clasado Inc. | Neue galactooligosaccharidzusammensetzung und herstellung davon |
| US20070166411A1 (en) * | 2005-12-16 | 2007-07-19 | Bristol-Myers Squibb Company | Nutritional supplement containing long-chain polyunsaturated fatty acids |
| EP1993576B1 (en) | 2006-03-07 | 2015-10-21 | Nestec S.A. | Synbiotic mixture |
| US20080003330A1 (en) * | 2006-06-30 | 2008-01-03 | Ricardo Rueda | Infant formulas for early brain development |
| WO2010115935A1 (en) | 2009-04-07 | 2010-10-14 | Glycom A/S | Synthesis of 2 ' -o-fucosyllactose |
| EP2251030A1 (en) | 2009-05-12 | 2010-11-17 | Nestec S.A. | Lactoferrin and brain health and development in infants |
| EP2258218A1 (en) | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
| CN105330705A (zh) * | 2010-02-19 | 2016-02-17 | 格礼卡姆股份公司 | 用于制备含n-乙酰乳糖胺的四糖乳糖-n-新四糖(lnnt)的方法 |
| EP2404507A1 (en) | 2010-07-08 | 2012-01-11 | Nestec S.A. | Array of age-tailored nutritional formula with optimum fat content |
| RU2013158289A (ru) * | 2011-06-08 | 2015-07-20 | Нестек С.А. | Питательные композиции, содержащие экзогенные компоненты мембран жировых глобул молока |
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- 2012-10-12 BR BR112014008944-2A patent/BR112014008944B1/pt active IP Right Grant
- 2012-10-12 MX MX2014004716A patent/MX350435B/es active IP Right Grant
- 2012-10-12 WO PCT/EP2012/070281 patent/WO2013057049A1/en not_active Ceased
- 2012-10-12 AU AU2012325060A patent/AU2012325060B2/en not_active Withdrawn - After Issue
- 2012-10-12 PL PL12772784T patent/PL2775852T3/pl unknown
- 2012-10-12 EP EP16174616.9A patent/EP3095331A1/en not_active Withdrawn
- 2012-10-12 EP EP12772784.0A patent/EP2775852B1/en active Active
- 2012-10-12 RU RU2014119844A patent/RU2607458C2/ru active
- 2012-10-12 IN IN1468DEN2014 patent/IN2014DN01468A/en unknown
- 2012-10-12 PT PT127727840T patent/PT2775852T/pt unknown
- 2012-10-12 US US14/352,236 patent/US20140271562A1/en not_active Abandoned
-
2014
- 2014-03-27 CL CL2014000759A patent/CL2014000759A1/es unknown
- 2014-05-16 ZA ZA2014/03591A patent/ZA201403591B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2430631C2 (ru) * | 2006-02-10 | 2011-10-10 | Нестек С.А. | Пребиотическая смесь олигосахаридов и пищевой продукт, ее содержащий |
| EP2272381A2 (en) * | 2007-11-26 | 2011-01-12 | Nestec S.A. | Age-tailored nutrition system for infants |
| EP2258216A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
| WO2011012655A1 (en) * | 2009-07-31 | 2011-02-03 | Nestec S.A. | Nutritional composition for breast-fed infants or pets with probiotics and selected nutrients |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140271562A1 (en) | 2014-09-18 |
| PH12014500443A1 (en) | 2014-04-14 |
| PT2775852T (pt) | 2016-11-08 |
| AU2012325060B2 (en) | 2015-11-19 |
| ZA201403591B (en) | 2016-01-27 |
| MY170185A (en) | 2019-07-09 |
| BR112014008944A2 (pt) | 2017-05-02 |
| CL2014000759A1 (es) | 2014-08-22 |
| CN103889238A (zh) | 2014-06-25 |
| CN103889238B (zh) | 2017-10-13 |
| BR112014008944B1 (pt) | 2020-09-15 |
| PL2775852T3 (pl) | 2017-02-28 |
| AU2012325060A1 (en) | 2014-03-13 |
| ES2601891T3 (es) | 2017-02-16 |
| MX2014004716A (es) | 2015-02-05 |
| RU2014119844A (ru) | 2015-11-27 |
| MX350435B (es) | 2017-09-06 |
| WO2013057049A1 (en) | 2013-04-25 |
| EP3095331A1 (en) | 2016-11-23 |
| EP2775852B1 (en) | 2016-08-17 |
| EP2775852A1 (en) | 2014-09-17 |
| IN2014DN01468A (cg-RX-API-DMAC7.html) | 2015-05-22 |
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| PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
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