RU2597746C2 - Способы и композиции для лечения вич-ассоциированной диареи - Google Patents

Способы и композиции для лечения вич-ассоциированной диареи Download PDF

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Publication number
RU2597746C2
RU2597746C2 RU2013123794/15A RU2013123794A RU2597746C2 RU 2597746 C2 RU2597746 C2 RU 2597746C2 RU 2013123794/15 A RU2013123794/15 A RU 2013123794/15A RU 2013123794 A RU2013123794 A RU 2013123794A RU 2597746 C2 RU2597746 C2 RU 2597746C2
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crofelemer
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RU2013123794/15A
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English (en)
Russian (ru)
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RU2013123794A (ru
Inventor
Уильям ФОРБС
Инок БОРТИ
Стивен КИНГ
Правин ЧАТУРВЕДИ
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Напо Фармасьютиклз, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45994461&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2597746(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
RU2013123794/15A 2010-10-31 2011-10-31 Способы и композиции для лечения вич-ассоциированной диареи RU2597746C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40862210P 2010-10-31 2010-10-31
US61/408,622 2010-10-31
US40933510P 2010-11-02 2010-11-02
US61/409,335 2010-11-02
US41624910P 2010-11-22 2010-11-22
US61/416,249 2010-11-22
US201161434379P 2011-01-19 2011-01-19
US61/434,379 2011-01-19
PCT/US2011/058549 WO2012058664A1 (en) 2010-10-31 2011-10-31 Methods and compositions for treating hiv-associated diarrhea

Publications (2)

Publication Number Publication Date
RU2013123794A RU2013123794A (ru) 2014-12-10
RU2597746C2 true RU2597746C2 (ru) 2016-09-20

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Application Number Title Priority Date Filing Date
RU2013123794/15A RU2597746C2 (ru) 2010-10-31 2011-10-31 Способы и композиции для лечения вич-ассоциированной диареи

Country Status (20)

Country Link
US (4) US8962680B2 (enExample)
EP (1) EP2632550B1 (enExample)
JP (2) JP6063385B2 (enExample)
CN (2) CN103370101A (enExample)
AU (1) AU2011320155B2 (enExample)
BR (1) BR112013010774A2 (enExample)
CA (1) CA2816416C (enExample)
DK (1) DK2632550T3 (enExample)
EC (1) ECSP13012650A (enExample)
ES (1) ES2635435T3 (enExample)
HK (1) HK1249036A1 (enExample)
HU (1) HUE035393T2 (enExample)
MX (1) MX348184B (enExample)
PE (1) PE20140036A1 (enExample)
PH (1) PH12013500857A1 (enExample)
PL (1) PL2632550T3 (enExample)
PT (1) PT2632550T (enExample)
RU (1) RU2597746C2 (enExample)
WO (1) WO2012058664A1 (enExample)
ZA (1) ZA201303136B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535419A (ja) 2006-05-01 2009-10-01 ナポ ファーマシューティカルズ インク． 便秘型過敏性腸症候群の治療方法
US8852649B2 (en) 2006-05-01 2014-10-07 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer
US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
BR112013010774A2 (pt) 2010-10-31 2017-03-21 Napo Pharmaceuticals Inc "usos de crofelemer no tratamento de diarreia associada ao hiv"
US20140163096A1 (en) * 2012-12-07 2014-06-12 Pam Golden Methods and compositions for treating hiv-associated diarrhea
US11389424B2 (en) 2017-03-09 2022-07-19 Napo Pharmaceuticals, Inc. Methods and compositions for treating chemotherapy-induced diarrhea
JOP20190276A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة
JOP20190275A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج اضطراب إسهال خِلقي
CA3128973A1 (en) 2019-03-04 2020-09-10 Bhaskar Bhattacharyya Data compression and communication using machine learning
JP2023538186A (ja) * 2020-06-19 2023-09-07 ナポ ファーマシューティカルズ インク． 化学療法誘発性下痢を治療するための方法及び組成物
WO2022115481A1 (en) * 2020-11-24 2022-06-02 Napo Pharmaceuticals, Inc. Methods and compositions for treating post-acute infection gastrointestinal disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080025966A1 (en) * 2004-01-30 2008-01-31 Currie Mark G Methods And Compositions For The Treatment Of Gastrointestinal disorders

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
EP0935417B1 (en) * 1996-10-16 2009-05-06 Napo Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
US20040071793A1 (en) 2002-10-05 2004-04-15 Bobrowski Paul J. Oral rehydration methods and compositions
CA2667449A1 (en) * 2005-06-22 2007-01-04 University Of Massachusetts Hiv-1 protease inhibitors, and methods of making and using them
JP2009524585A (ja) 2005-12-15 2009-07-02 バイエル・ヘルスケア・アクチェンゲゼルシャフト ウイルス感染を処置するためのジアリールウレア
JP2009535419A (ja) 2006-05-01 2009-10-01 ナポ ファーマシューティカルズ インク． 便秘型過敏性腸症候群の治療方法
US8852649B2 (en) 2006-05-01 2014-10-07 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer
US20070254050A1 (en) * 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
WO2010021681A2 (en) 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
EA023814B1 (ru) 2009-08-26 2016-07-29 Гленмарк Фармасьютикалс Лтд. Способ получения полимерных композиций на основе проантоцианидина для фармацевтических форм
AU2010303577B2 (en) 2009-10-06 2015-10-22 Napo Pharmaceuticals, Inc. Methods of treating diseases with proanthocyanidin oligomers such as crofelemer
US20110087530A1 (en) 2009-10-09 2011-04-14 Visa U.S.A. Inc. Systems and Methods to Provide Loyalty Programs
BR112013010774A2 (pt) 2010-10-31 2017-03-21 Napo Pharmaceuticals Inc "usos de crofelemer no tratamento de diarreia associada ao hiv"
BR112013018688B1 (pt) 2011-01-27 2021-08-24 Napo Pharmaceuticals, Inc Método de produção de uma composição polimérica de proantocianidina
RU2014124981A (ru) 2011-12-22 2016-02-10 Гленмарк Фармасьютикалс Лимитед Неэнтеросолюбильная фармацевтическая композиция, содержащая крофелемер
US20140163096A1 (en) 2012-12-07 2014-06-12 Pam Golden Methods and compositions for treating hiv-associated diarrhea

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080025966A1 (en) * 2004-01-30 2008-01-31 Currie Mark G Methods And Compositions For The Treatment Of Gastrointestinal disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CRUTCHLEY RD et al. Crofelemer, a novel agent for treatment of secretory diarrhea. Ann Pharmacother.2010 May; 44(5):878-84, реферат, найдено 23.09.2015, найдено из PubMed PMID:20388859. *
HOLODNIY M. et al. A lobule blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS. Am.J.Gastroenterol. 1999 Nov; 94(11):3267-73 *
HOLODNIY M. et al. A lobule blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS. Am.J.Gastroenterol. 1999 Nov; 94(11):3267-73;MANGEL AW et al. ";Evaluation of crofelemer in the treatment of diarrhea-predominant irritable bowel syndrome patients";. Digestion, 2008;78(4):180-6, реферат, найдено 23.09.2015, найдено из PubMed PMID:19092244;CRUTCHLEY RD et al. Crofelemer, a novel agent for treatment of secretory diarrhea. Ann Pharmacother.2010 May; 44(5):878-84, реферат, найдено 23.09.2015, найдено из PubMed PMID:20388859. *
MANGEL AW et al. ";Evaluation of crofelemer in the treatment of diarrhea-predominant irritable bowel syndrome patients";. Digestion, 2008;78(4):180-6, реферат, найдено 23.09.2015, найдено из PubMed PMID:19092244 *

Also Published As

Publication number Publication date
JP6310971B2 (ja) 2018-04-11
CA2816416C (en) 2020-02-11
AU2011320155A1 (en) 2013-05-09
MX348184B (es) 2017-06-02
CN103370101A (zh) 2013-10-23
BR112013010774A2 (pt) 2017-03-21
JP2017019806A (ja) 2017-01-26
ZA201303136B (en) 2016-01-27
EP2632550B1 (en) 2017-05-03
PE20140036A1 (es) 2014-01-31
CN107595836A (zh) 2018-01-19
PL2632550T3 (pl) 2017-10-31
PH12013500857A1 (en) 2018-01-17
US20120107370A1 (en) 2012-05-03
US9585868B2 (en) 2017-03-07
HUE035393T2 (en) 2018-05-02
CA2816416A1 (en) 2012-05-03
AU2011320155B2 (en) 2016-02-25
WO2012058664A1 (en) 2012-05-03
US20120184605A1 (en) 2012-07-19
US8962680B2 (en) 2015-02-24
EP2632550A4 (en) 2014-04-23
MX2013004873A (es) 2013-08-21
PT2632550T (pt) 2017-08-02
EP2632550A1 (en) 2013-09-04
US20150190367A1 (en) 2015-07-09
ES2635435T3 (es) 2017-10-03
ECSP13012650A (es) 2013-10-31
DK2632550T3 (en) 2017-08-07
RU2013123794A (ru) 2014-12-10
US20140294903A1 (en) 2014-10-02
HK1249036A1 (zh) 2018-10-26
JP2013540826A (ja) 2013-11-07
JP6063385B2 (ja) 2017-01-18

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