RU2595865C2 - Фосфолипидный депо-препарат - Google Patents

Фосфолипидный депо-препарат Download PDF

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Publication number
RU2595865C2
RU2595865C2 RU2013112353/15A RU2013112353A RU2595865C2 RU 2595865 C2 RU2595865 C2 RU 2595865C2 RU 2013112353/15 A RU2013112353/15 A RU 2013112353/15A RU 2013112353 A RU2013112353 A RU 2013112353A RU 2595865 C2 RU2595865 C2 RU 2595865C2
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RU
Russia
Prior art keywords
depot preparation
water
viscosity
oil
vancomycin
Prior art date
Application number
RU2013112353/15A
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English (en)
Russian (ru)
Other versions
RU2013112353A (ru
Inventor
Хайлян Чэнь
Эндрю Сянь Чэнь
Душиант СУРАКАНТИ
Франклин ОКУМУ
Original Assignee
Др. Редди'З Лабораториз, Лтд.
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Application filed by Др. Редди'З Лабораториз, Лтд. filed Critical Др. Редди'З Лабораториз, Лтд.
Publication of RU2013112353A publication Critical patent/RU2013112353A/ru
Application granted granted Critical
Publication of RU2595865C2 publication Critical patent/RU2595865C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
RU2013112353/15A 2010-08-20 2010-12-17 Фосфолипидный депо-препарат RU2595865C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37550210P 2010-08-20 2010-08-20
US61/375,502 2010-08-20
PCT/US2010/061015 WO2012023955A1 (en) 2010-08-20 2010-12-17 Phospholipid depot

Publications (2)

Publication Number Publication Date
RU2013112353A RU2013112353A (ru) 2014-09-27
RU2595865C2 true RU2595865C2 (ru) 2016-08-27

Family

ID=43928096

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2013112353/15A RU2595865C2 (ru) 2010-08-20 2010-12-17 Фосфолипидный депо-препарат

Country Status (13)

Country Link
US (4) US9132144B2 (enExample)
EP (1) EP2605751A1 (enExample)
JP (1) JP5752248B2 (enExample)
KR (1) KR101793101B1 (enExample)
CN (1) CN103179951B (enExample)
AU (1) AU2010359346B2 (enExample)
BR (1) BR112013003934A2 (enExample)
CA (1) CA2809022C (enExample)
MX (1) MX366099B (enExample)
NZ (1) NZ608210A (enExample)
RU (1) RU2595865C2 (enExample)
WO (1) WO2012023955A1 (enExample)
ZA (1) ZA201301833B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11337894B2 (en) 2018-06-15 2022-05-24 James T. Doubet Syringe adapter for animal medication
US11090444B2 (en) 2018-06-15 2021-08-17 James T. Doubet Syringe adapter for medication
US11097058B2 (en) 2018-06-15 2021-08-24 James T. Doubet Syringe adapter for medication
US10709850B2 (en) 2018-06-15 2020-07-14 James T. Doubet Syringe adapter for medication
ES2798263T3 (es) 2005-12-08 2020-12-10 Insmed Inc Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
AU2010359346B2 (en) * 2010-08-20 2015-01-29 Dr. Reddy's Laboratories Sa Phospholipid depot
EP2629779B1 (en) * 2010-10-22 2017-06-21 Dr. Reddy's Laboratories SA. Use of storage stable viscous phospholipid depot to treat wounds
CN104427977B (zh) 2012-05-10 2018-02-02 佩因拉佛姆有限公司 局部麻醉剂的储库制剂及其制备方法
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
WO2015161065A1 (en) * 2014-04-16 2015-10-22 Biomet Manufacturing, Llc Methods for coating implant surfaces to treat surgical infections
WO2015158823A1 (de) 2014-04-16 2015-10-22 Veyx-Pharma Gmbh Veterinärpharmazeutische zusammensetzung und deren verwendung
AU2015253417B2 (en) 2014-04-28 2020-02-20 Dimerx, Inc. Pharmaceutically active dimers linked through phenolic hydroxyl groups
MX384843B (es) 2014-05-15 2025-03-14 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
US20170165374A1 (en) * 2015-11-18 2017-06-15 Insmed, Inc. Compositions and methods for treating bacterial infections
CN107522735A (zh) * 2017-09-21 2017-12-29 安徽元创科技有限公司 以溶剂法生产低粘度磷脂产品的方法
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
EP3787602A4 (en) 2018-05-02 2022-03-23 Insmed Incorporated PROCESS FOR THE MANUFACTURE OF LIPOSOMAL DRUG FORMULATIONS
USD1126398S1 (en) 2018-06-15 2026-05-12 James T. Doubet Syringe adapter for medication
USD890925S1 (en) 2018-06-15 2020-07-21 James T. Doubet Syringe adapter for medication
US20190388625A1 (en) 2018-06-15 2019-12-26 James T. Doubet Syringe adapter for medication
CA3110931A1 (en) * 2018-10-21 2020-04-30 James T. DOUBET Syringe adapter for medication
WO2020146788A1 (en) * 2019-01-11 2020-07-16 University Of Washington Combination pharmaceutical compositions and methods thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2193497C (en) * 1994-06-21 2000-10-17 S. Esmail Tabibi Controlled release aqueous emulsion
US20020107265A1 (en) * 1999-10-18 2002-08-08 Feng-Jing Chen Emulsion compositions for polyfunctional active ingredients
US20060067952A1 (en) * 2004-09-28 2006-03-30 Sd Pharmaceuticals, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
WO2007133711A2 (en) * 2006-05-12 2007-11-22 Adventrx Pharmaceuticals, Inc. Pharmaceutical compositions for vein irritating drugs
RU2376012C1 (ru) * 2008-05-20 2009-12-20 Федеральное государственное учреждение здравоохранения Волгоградский научно-исследовательский противочумный институт Роспотребнадзора Способ получения комбинированного липосомального антибактериального препарата

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US4252793A (en) 1979-06-18 1981-02-24 American Lecithin Company Injectable lecithin preparation
NZ223660A (en) 1987-03-05 1990-11-27 Liposome Co Inc Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity
CH681427A5 (enExample) 1987-07-01 1993-03-31 Zambon Spa
SI9300468A (en) 1992-10-14 1994-06-30 Hoffmann La Roche Injectable composition for the sustained release of biologically active compounds
JPH0881360A (ja) * 1994-07-13 1996-03-26 Wakamoto Pharmaceut Co Ltd 安定な脂肪乳剤
CA2153553A1 (en) * 1994-07-13 1996-01-14 Hidekazu Suzuki Stable lipid emulsion
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
IL139177A0 (en) 2000-10-20 2001-11-25 S C Republic Dev S R L Sustained release drug delivery system
US20050049209A1 (en) * 2003-08-06 2005-03-03 Chen Andrew Xian Pharmaceutical compositions for delivering macrolides
JP2008502690A (ja) * 2004-06-15 2008-01-31 アンドリュー シァン チェン， リン脂質組成物ならびにその調製方法および使用方法
US7547455B2 (en) * 2006-09-20 2009-06-16 Academia Sinica Cancer and inflammatory disorder treatment
AU2010359346B2 (en) * 2010-08-20 2015-01-29 Dr. Reddy's Laboratories Sa Phospholipid depot

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2193497C (en) * 1994-06-21 2000-10-17 S. Esmail Tabibi Controlled release aqueous emulsion
US20020107265A1 (en) * 1999-10-18 2002-08-08 Feng-Jing Chen Emulsion compositions for polyfunctional active ingredients
US20060067952A1 (en) * 2004-09-28 2006-03-30 Sd Pharmaceuticals, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
WO2007133711A2 (en) * 2006-05-12 2007-11-22 Adventrx Pharmaceuticals, Inc. Pharmaceutical compositions for vein irritating drugs
RU2376012C1 (ru) * 2008-05-20 2009-12-20 Федеральное государственное учреждение здравоохранения Волгоградский научно-исследовательский противочумный институт Роспотребнадзора Способ получения комбинированного липосомального антибактериального препарата

Also Published As

Publication number Publication date
US20120046220A1 (en) 2012-02-23
MX2013002005A (es) 2013-06-24
EP2605751A1 (en) 2013-06-26
ZA201301833B (en) 2014-05-28
US9682040B2 (en) 2017-06-20
CN103179951B (zh) 2016-01-20
US20170056326A1 (en) 2017-03-02
JP5752248B2 (ja) 2015-07-22
CA2809022A1 (en) 2012-02-23
US20150306173A1 (en) 2015-10-29
KR20130112870A (ko) 2013-10-14
KR101793101B1 (ko) 2017-11-02
AU2010359346A1 (en) 2013-04-04
AU2010359346B2 (en) 2015-01-29
US9132144B2 (en) 2015-09-15
NZ608210A (en) 2015-02-27
US20170246109A1 (en) 2017-08-31
JP2013534244A (ja) 2013-09-02
MX366099B (es) 2019-06-27
CN103179951A (zh) 2013-06-26
BR112013003934A2 (pt) 2016-06-07
WO2012023955A1 (en) 2012-02-23
US9522169B2 (en) 2016-12-20
RU2013112353A (ru) 2014-09-27
CA2809022C (en) 2017-01-03

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