RU2583299C2 - Новые пептиды с анальгетическим эффектом, ингибирующие asic-rfyfks - Google Patents

Новые пептиды с анальгетическим эффектом, ингибирующие asic-rfyfks Download PDF

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RU2583299C2
RU2583299C2 RU2013108262/10A RU2013108262A RU2583299C2 RU 2583299 C2 RU2583299 C2 RU 2583299C2 RU 2013108262/10 A RU2013108262/10 A RU 2013108262/10A RU 2013108262 A RU2013108262 A RU 2013108262A RU 2583299 C2 RU2583299 C2 RU 2583299C2
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Russia
Prior art keywords
peptide
asicalgin
sequence
channels
seq
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RU2013108262/10A
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Russian (ru)
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RU2013108262A (ru
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Эрик ЛИНГУЭЛЬЯ
Сильви ДЬОШО
Анн БАРОН-ФОРСТЕР
Мигель САЛИНАС
Мишель ЛАЗДУНСКИ
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Сантр Насьональ Де Ля Решерш Сьянтифик
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2013108262/10A 2010-07-26 2011-07-26 Новые пептиды с анальгетическим эффектом, ингибирующие asic-rfyfks RU2583299C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1003136 2010-07-26
FR1003136A FR2963010B1 (fr) 2010-07-26 2010-07-26 Nouveaux peptides avec des effets analgesiques et inhibant les canaux asic
PCT/FR2011/051800 WO2012022894A1 (fr) 2010-07-26 2011-07-26 Nouveaux peptides avec des effets analgesiques et inhibant les canaux asic

Publications (2)

Publication Number Publication Date
RU2013108262A RU2013108262A (ru) 2014-09-10
RU2583299C2 true RU2583299C2 (ru) 2016-05-10

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RU2013108262/10A RU2583299C2 (ru) 2010-07-26 2011-07-26 Новые пептиды с анальгетическим эффектом, ингибирующие asic-rfyfks

Country Status (13)

Country Link
US (1) US8987207B2 (OSRAM)
EP (1) EP2598523B1 (OSRAM)
JP (1) JP6000245B2 (OSRAM)
CN (1) CN103097404B (OSRAM)
AU (1) AU2011290589A1 (OSRAM)
BR (1) BR112013001863A2 (OSRAM)
CA (1) CA2806471C (OSRAM)
FR (1) FR2963010B1 (OSRAM)
MX (1) MX336586B (OSRAM)
RU (1) RU2583299C2 (OSRAM)
SG (1) SG187877A1 (OSRAM)
WO (1) WO2012022894A1 (OSRAM)
ZA (1) ZA201300662B (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105233286B (zh) * 2015-09-10 2018-10-30 上海交通大学医学院 含酸敏感离子通道调控剂的制剂及其在治疗瘙痒中的用途
CN105412932B (zh) * 2015-10-26 2019-08-16 上海交通大学医学院 含ASIC1a与RIP1结合抑制剂的制剂及其抑制神经元死亡的用途
CN112618722A (zh) * 2016-11-22 2021-04-09 上海交通大学医学院 酸敏感离子通道调控剂的用途
CN107384952A (zh) * 2017-08-23 2017-11-24 湖南甲骨文生物医药有限公司 用于筛选ASICs作用蛋白的酵母双杂交诱饵载体的构建方法
CN114729034B (zh) * 2019-06-04 2024-01-12 上海科技大学 亲和力成熟的抗ASIC1a抗体
RU2768484C1 (ru) * 2021-05-24 2022-03-24 Закрытое акционерное общество "СКАЙ ЛТД" Фармацевтическая композиция иммуностимулирующих веществ мурамилпептидной природы

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776896A (en) 1996-01-03 1998-07-07 Zeneca Limited Analgesic peptides from venom of grammostola spatulata and use thereof
JP4959226B2 (ja) * 2006-05-19 2012-06-20 独立行政法人産業技術総合研究所 スリーフィンガー様蛋白質ライブラリ
JP2008193923A (ja) * 2007-02-09 2008-08-28 Janusys Kk 蛋白質ライブラリ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YING-YING HE et al., Cloning and purification of alpha-neurotoxins from king cobra (Ophiophagus hannah), Toxicon, 2004, v.44, is.3, p.295-303. VEGA R. et al., Acid-sensing ionic-channel functional expression in the vestibular endorgans, Neurosci Lett., 2009, v.463, is.3, p.199-202. СИДОРОВ А.В., Регуляция и модуляция нейронных функций при колебаниях уровня рН интерстиция, Вестник БГУ, 2008, сер.2, номер 3, стр.67-72. PAKULA A.A. et al., Genetic analysis of protein stability and function. Anna. Rev. Genet. 1989, v.23, p.289-310. *

Also Published As

Publication number Publication date
SG187877A1 (en) 2013-03-28
EP2598523A1 (fr) 2013-06-05
CA2806471A1 (fr) 2012-02-23
ZA201300662B (en) 2013-09-25
FR2963010B1 (fr) 2014-08-15
AU2011290589A1 (en) 2013-03-07
US20130196923A1 (en) 2013-08-01
RU2013108262A (ru) 2014-09-10
CN103097404B (zh) 2015-09-16
JP2013535965A (ja) 2013-09-19
MX2013001020A (es) 2014-04-14
CA2806471C (fr) 2020-07-07
MX336586B (es) 2016-01-21
US8987207B2 (en) 2015-03-24
WO2012022894A4 (fr) 2012-04-12
FR2963010A1 (fr) 2012-01-27
WO2012022894A1 (fr) 2012-02-23
EP2598523B1 (fr) 2015-09-09
JP6000245B2 (ja) 2016-09-28
CN103097404A (zh) 2013-05-08
BR112013001863A2 (pt) 2016-05-31

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