RU2539007C1 - Method of treating rheumatoid arthritis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: according to the method, the affected joints are exposed. The exposure is performed by electrophoresis with 2% pentoxifylline. The pentoxifylline solution is introduced from an anode at current intensity 15 mA. The 15-minute introduction is performed at current density 0.05-0.1 mA/cm². The therapeutic course is 10 procedures.

EFFECT: method is non-invasive, easy to implement; it reduces the length of treatment.

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Description

The invention relates to medicine, namely to rheumatology, and can be used for the complex treatment of patients with rheumatoid arthritis.

Rheumatoid arthritis is a chronic immune-mediated disease that affects both the synovial membrane of joints and visceral systems (Rheumatology: Clinical recommendations / Edited by Acad. RAMS E.L. Nasonova. - 2nd ed., Rev. And add. - M. : GEOTAR-Media, 2011 .-- S.90-230). Immuno-mediated damage to the circulatory system in patients with rheumatoid arthritis affects the vessels of medium and small caliber, which leads to vasculitis and depletion of tissue perfusion and microcirculation of blood (Radenska-Lopovok S.G., Nasonova V.A. Vasculitis and vasculopathy: common signs and characteristics. Therapeutic Archive, 1998, No. 11, S.58-59).

Currently relevant is the creation of a method for the treatment of rheumatoid arthritis: non-invasive, with high therapeutic activity, ease of use, requiring minimal time.

A known method of treating rheumatoid arthritis with a patch with a magnetic powder of rare earth metals, a nanopowder-producer of infrared radiation in the far infrared region of the spectrum (Nanoplast-forte, LLC NanoTek Pharma, Russia), applied to the area of the affected joints for 12 hours (Shostak N.A. Nanotechnology in the optimization of local therapy for pain syndromes / N.A. Shostak, A.A. Klimenko // Medical Council. - 2012. - No. 8. - P.1-6).

The disadvantages of this method are:

1. The adhesive base of the transdermal patch is capable of causing allergic reactions.

2. The procedure is carried out for a long time (12 hours).

3. After the procedure, the level of microcirculation quickly (within 10-15 minutes) returns to the original, since the body does not create a depot of the drug substance.

Closest to the technical result achieved is a method of treating rheumatoid arthritis by administering levamisole. With a solution of levamisole, the gaskets from the flannel are moistened and strengthened in the region of the XII thoracic - I lumbar vertebra on both sides of the spinal column; metal electrodes are connected to the terminal of the positive pole of the direct current source, and the negative electrode is connected to a similar gasket in the supra umbilical region. Levamisole is administered bipolar. The current density of 0.05-0.1 mA / cm ^{2 the} duration of exposure is 20 minutes, 10 treatments per treatment course. One day, the procedure is released transabdominally, and the next day, on the affected joints. To do this, flannel pads moistened with a solution of levamisole are strengthened on both sides of the joint and bipolar electrophoresis is performed. The current density of 0.05-0.1 mA / cm ² , the exposure time of 20 minutes, 10 treatments per treatment course (Patent SU 1178454, A1, 09/15/1985).

The disadvantages of this method are:

1. The injected drug - levamisole does not have angioprotective and vasodilating effects.

2. The injected drug - levamisole does not improve microcirculation.

The authors proposed an effective method for the treatment of rheumatoid arthritis, which has high therapeutic efficacy, ease of use, requiring minimal time, non-invasive.

The technical result of the proposed method is to increase the effectiveness of the treatment of rheumatoid arthritis.

The technical result is achieved by conducting electrophoresis of a 2% solution of pentoxifylline, which is introduced from the anode, with a current strength of 15 mA.

The method is as follows.

Napkins moistened with a 2% solution of pentoxifylline are applied to the area of affected joints (Trental, Sanofi-aventis, France). Use carbon electrodes. Electrophoresis is carried out at a current density of 0.05-0.1 mA / cm ² , a current strength of 10-15 mA, the duration of the procedures is 15 minutes. The drug is administered from the anode. Procedures are carried out daily, 10 procedures per course.

Equipment and materials: Potok-1 apparatus (EMA plant, Yekaterinburg, Russia), three gauze pads, two current-carrying electrodes, 5 milliliters of pentoxifylline (Trental, Sanofi-aventis, France) in the form of a 2% solution in water for injection for 1 procedure.

Indications: rheumatoid arthritis, articular form.

The use of the drug in the treatment of rheumatoid arthritis is known only by intravenous infusion and administration in tablet form.

Contraindications: decompensation of diabetes mellitus, cardiovascular pathology, cancer, pregnancy, epilepsy, progressive synovitis, rapid development of functional failure, early postoperative period.

Clinical example. Patient K., 67 years old, was hospitalized in the city rheumatology center of Baranul with a diagnosis of rheumatoid arthritis, articular form, seropositive, II x-ray stage, activity II, insufficiency of joint function II. Upon admission, she complained of pain in the joints of the fingers of the hands, morning stiffness for 3 hours, numbness and cooling of the skin of the fingers in the cold and during excitement. In the hospital, the patient was prescribed standard therapy: methotrexate 15 milligrams per week, ketoprofen 100 milligrams per day, folic acid 3 milligrams per day. During pharmacological therapy, a slightly positive clinical dynamics was obtained, however, morning stiffness for 2 hours, severe pain in the joints of the hands at rest (up to 70 points on the visual analogue scale), numbness and cooling of the fingers of the hands during excitement and in the cold remained. The patient is aimed at rehabilitation treatment using pentoxifylline electrophoresis. After 10 procedures, the time of morning stiffness in the joints of the hands decreased significantly to 30 minutes, pain in the joints of the hands decreased (up to 30 points on a visual analogue scale). Cooling of the skin of the fingers and blanching when exposed to low ambient temperature and emotional factor are stopped.

The inventive method for the treatment of rheumatoid arthritis by electrophoresis with pentoxifylline has high therapeutic efficacy, ease of use, requires minimal time, non-invasive, which improves the effectiveness of the treatment.

The inventive method will be widely used in rheumatology departments of clinics.

Claims (1)

A method for the treatment of rheumatoid arthritis, including the impact on the affected joints by electrophoresis at a current density of 0.05-0.1 mA / cm ² for 15 minutes, in a course of 10 procedures, characterized in that they carry out electrophoresis of a 2% solution of pentoxifylline, which is administered from the anode, with a current of 15 mA.