RU2505313C2 - Композиции и способы направленного устранения мутационного ускользания в направленной терапии рака - Google Patents

Композиции и способы направленного устранения мутационного ускользания в направленной терапии рака Download PDF

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RU2505313C2
RU2505313C2 RU2009138327/15A RU2009138327A RU2505313C2 RU 2505313 C2 RU2505313 C2 RU 2505313C2 RU 2009138327/15 A RU2009138327/15 A RU 2009138327/15A RU 2009138327 A RU2009138327 A RU 2009138327A RU 2505313 C2 RU2505313 C2 RU 2505313C2
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yeast
mutant polypeptide
bcr
abl
cell
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RU2009138327/15A
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Russian (ru)
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RU2009138327A (ru
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Дэвид ЭЙПЕЛИАН
Алекс ФРАНЦУЗОФФ
Тимоти К. РОДЕЛЛ
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Глоубиммьюн, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2009138327/15A 2007-03-19 2008-01-17 Композиции и способы направленного устранения мутационного ускользания в направленной терапии рака RU2505313C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89568907P 2007-03-19 2007-03-19
US60/895,689 2007-03-19
US91079607P 2007-04-09 2007-04-09
US60/910,796 2007-04-09
PCT/US2008/051348 WO2008115610A1 (en) 2007-03-19 2008-01-17 Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer

Publications (2)

Publication Number Publication Date
RU2009138327A RU2009138327A (ru) 2011-04-27
RU2505313C2 true RU2505313C2 (ru) 2014-01-27

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RU2009138327/15A RU2505313C2 (ru) 2007-03-19 2008-01-17 Композиции и способы направленного устранения мутационного ускользания в направленной терапии рака

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Country Link
US (1) US8501167B2 (cg-RX-API-DMAC10.html)
EP (1) EP2134358A1 (cg-RX-API-DMAC10.html)
JP (2) JP5579451B2 (cg-RX-API-DMAC10.html)
KR (1) KR20100015661A (cg-RX-API-DMAC10.html)
CN (1) CN101730542A (cg-RX-API-DMAC10.html)
AU (1) AU2008229295B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0809247A2 (cg-RX-API-DMAC10.html)
CA (1) CA2681246A1 (cg-RX-API-DMAC10.html)
IL (1) IL201039A0 (cg-RX-API-DMAC10.html)
MX (1) MX2009010066A (cg-RX-API-DMAC10.html)
NZ (1) NZ580444A (cg-RX-API-DMAC10.html)
RU (1) RU2505313C2 (cg-RX-API-DMAC10.html)
WO (1) WO2008115610A1 (cg-RX-API-DMAC10.html)

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EP2331125A4 (en) 2008-09-19 2013-03-27 Globeimmune Inc IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS
ES2660597T3 (es) 2009-04-17 2018-03-23 Globeimmune, Inc. Composiciones inmunoterápicas de combinación contra el cáncer y métodos
US8911722B2 (en) 2009-09-14 2014-12-16 The Regents Of The University Of Colorado, A Body Corporate Modulation of yeast-based immunotherapy products and responses
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KR102103319B1 (ko) 2012-06-26 2020-04-22 바이오디식스, 인크. 면역반응 발생 요법으로 치료하기 위해 암환자들의 선택, 및 선택해제를 위한 질량-스펙트럼법
WO2014024965A1 (ja) * 2012-08-10 2014-02-13 学校法人 久留米大学 上皮成長因子受容体のt790m点突然変異配列に由来する抗原ペプチド
MX374829B (es) 2013-03-19 2025-03-06 Globeimmune Inc Composición a base de levadura para usarse para tratar cordoma.
US9782473B2 (en) 2013-03-26 2017-10-10 Globeimmune, Inc. Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
TWI654200B (zh) 2013-08-30 2019-03-21 環球免疫公司 治療或預防結核病的組合物及方法
CA2948803A1 (en) 2014-04-11 2015-10-15 Globeimmune, Inc. Yeast-based immunotherapy and type i interferon sensitivity
TWI748957B (zh) 2015-08-03 2021-12-11 美商環球免疫公司 經修飾之酵母-短尾畸型（Ｂｒａｃｈｙｕｒｙ）免疫治療組合物
SG11201808196UA (en) * 2016-03-31 2018-10-30 Neon Therapeutics Inc Neoantigens and methods of their use
EP3606550A2 (en) 2017-04-03 2020-02-12 Neon Therapeutics, Inc. Protein antigens and uses thereof
TW201930340A (zh) 2017-12-18 2019-08-01 美商尼恩醫療公司 新抗原及其用途
CN119818663A (zh) 2018-05-15 2025-04-15 全球免疫公司 用于诱导细胞免疫应答的重组酵母裂解物
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Publication number Publication date
AU2008229295B2 (en) 2014-05-22
JP5579451B2 (ja) 2014-08-27
NZ580444A (en) 2012-02-24
BRPI0809247A2 (pt) 2014-09-09
JP2010522180A (ja) 2010-07-01
JP2014156467A (ja) 2014-08-28
IL201039A0 (en) 2010-05-17
CN101730542A (zh) 2010-06-09
US20100111912A1 (en) 2010-05-06
CA2681246A1 (en) 2008-09-25
AU2008229295A1 (en) 2008-09-25
MX2009010066A (es) 2009-10-12
EP2134358A1 (en) 2009-12-23
RU2009138327A (ru) 2011-04-27
WO2008115610A1 (en) 2008-09-25
KR20100015661A (ko) 2010-02-12
US8501167B2 (en) 2013-08-06

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