RU2490021C1 - Agent for treating notoedric mange in rabbits - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to veterinary science. An agent for treating notoedric mange in rabbits contains (wt %): alpha-cypermethrin - 0.25; clove oil - 50.0; triethylene glycol - 49.75. The agent is used by direct topical application onto an involved scalp in the rabbits twice every 7 days in a dose of 2-5 ml.

EFFECT: method enables producing a high therapeutic effect.

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Description

The invention relates to the field of veterinary medicine and can be used to treat rabbits for nootrosis.

Currently, cypermethrin-based preparations are successfully being introduced into the production of animal ectoparasites. Cypermethrin-alpha-cyano-3-phenoxy-benzyl [(1D) - cis, trans-3 (2,2-dichlorvinyl) -2,2-dimethylcyclopropanecarboxylate] is produced in the form of an emulsifiable concentrate with a content of from 8 to 40% d. ., A 20% wettable powder (sp.) And a 5% solution for ULV under the names ectomine, cymbush and cinometrin. All these funds have a detrimental effect on ectoparasites of animals in 0.05-0.1% concentrations in the form of aqueous emulsions; 0.021-0.05% aqueous emulsions of cymbush and 0.1% aqueous emulsion of ectomine in psoroptosis of cattle and sheep [1-4]. With rabies nosedrosis, these drugs are not used.

The known drug Creolin-X is an insecticide and acaricidal drug in the form of a solution for external use, containing 2.5% or 5% cypermethrin as the active substance, and phenol-free coal creole as an excipient. It has intestinal-contact action, is active against sarcoptoid, ixodid ticks and insects [5]. The disadvantages of this drug include its low selectivity for ticks and lack of effectiveness against ticks Notoedres cati var. cuniculi.

The aim of the invention is an effective fight against notedrosis of rabbits. In this regard, a new tool has been developed that acts on ticks - Notoedres cati var. cuniculi with 100% therapeutic efficacy.

This goal is achieved in that alpha-cypermethrin is used as the active substance, clove oil is used as a prolonging substance, and triethylene glycol is a solvent, at their concentration in wt.% In the total composition of the product:

Alpha Cypermethrin 0.25

Clove oil - 50.0

Triethylene glycol - 49.75.

Alpha-cypermethrin is a mixture (1: 1) of isomers of cypermethrin: (S) -alpha-cyano-3-phenoxybenzyl ether (1R) -cis-3- (2,2-dichlorvinyl) -2,2-dimethylcyclopropanecarboxylic acid and (R ) -alpha-cyano-3-phenoxybenzyl ester of (1S) -cis-3- (2,2-dichlorvinyl) -2,2-dimethyl-cyclopropanecarboxylic acid. According to the mechanism of action on the body of arthropods, cypermethrin refers to potent neurotropic poisons. It is used to treat animal acaroses.

Clove oil contains useful substances: caryophyllene, tannins and fatty substances. It has antibacterial, antiviral, antiseptic and analgesic effects.

Triethylene glycol is necessary for the dissolution of alpha-cypermethrin in the preparation, harmless to the body, which also has a disinfecting effect.

The drug is obtained by dissolving 0.25 wt.% Ivermectin in triethylene glycol and adding 50 wt.% Clove oil.

This form of the drug is used by direct topical application to the affected scalp of rabbits twice with an interval of 7 days at a dose of 2-5 ml (depending on the area of invasion).

The invention is illustrated by the following examples.

Example 1. 49.75 cm ^{3 of} triethylene glycol was placed in a 100 cm ³ volumetric flask in which 0.25 g of alpha cypermethrin was dissolved, then 50 g of clove oil was added and mixed thoroughly.

Example 2. To substantiate the therapeutic efficacy of the claimed agent for rabies nosedrosis in ZAO AKC "Roshchinsky", Tyumen region, Tyumen region, 1020 spontaneously infected rabbits were used, of which 2 groups were formed. All animals were treated twice with an interval of 7 days by direct topical application to the affected scalp of rabbits in a dose of 2-5 ml (depending on the area of invasion). The second experimental group was treated with a well-known tool based on cypermethrin - creolin-X, according to the instructions for use.

Processing rabbits using the claimed funds showed 100% acaricidal efficacy; no live ticks were found in scrapings; the skin on the face of rabbits was completely cleaned of scales for 5-12 days. The proposed method provided insecticaricidal protection against cutaneous ticks for at least 50 days. Biorex treatment of rabbits showed 93.1% acaricidal efficacy.

The claimed rabbit nosedrosis therapy agent did not cause signs of toxicosis or other adverse signs in animals after acaricidal treatment and exceeds the therapeutic efficacy of the recommended agent by 6.9%.

Information sources

1. Byazrov A.I., Kan P.T. Cypermethrin for combating ixodid ticks // Veterinary medicine. - 1990. - No. 8. - S. 35-36.

2. Zagrebin A.I., Veselkin G.A., Tikhomirov S.M. Cypermethrin to protect cattle from flies. // Veterinary medicine. 1990. - No. 6. - S.24-27.

3. Uzakov U.Ya., Dzhalilova S.G., Parmanova S.X., Karimov N.A. Tsimbush is an effective acaricide. // Veterinary medicine. - 1991. - No. 11. - S.11.

4. Timofeev B.A., Kiryutin G.V., et al. Biorex - a new anti-scab drug based on cypermethrin. // Veterinary medicine. - 1991. - No. 3. - S. 54-55.

5. Instructions for use of Creolin-X for the prevention and treatment of arachno-entomoses of animals. Veterinary Preparations Plant, Russia.

Claims (1)

An agent for the treatment of rabies nosedrosis containing alpha-cypermethrin, triethylene glycol, characterized in that it additionally contains clove oil in the following ratio, wt.%:
Alpha Cypermethrin 0.25
Clove Oil 50.0
Triethylene glycol 49.75
while the tool is used by direct topical application to the affected scalp of rabbits twice with an interval of 7 days at a dose of 2-5 ml.