RU2483738C1 - Method for lipid metabolism correction in individuals with risk of developing atherosclerosis with use of mare's milk, phytocomplex and mineral water - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely therapy and physiotherapy and may be used for lipid metabolism correction in individuals with a risk of developing atherosclerosis. For this purpose with underlying basic health resort treatment, weak and medium mare's milk of a Turner degree of 71-100° in the amount of 200-250 ml three times a day, 15-20 minutes before meals; herbal tea "Lan" combined with hydrocarbonate sulphate-calcium magnesium low-mineralised mineral water at 3-4 ml per 1 kg of body weight three times a day 15-20 minutes before meals. The length of the therapeutic course is 24 days.

EFFECT: effect with the use of natural therapeutic factors provides the effective correction of lipid metabolism ensured by lowering atherogenic lipids, increasing CS HDLP, inhibiting lipid peroxidation and enhancing the activity of antioxidant enzymes.

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Description

The present invention relates to medicine, namely to reconstructive medicine, and can be used for prophylaxis and complex exposure in individuals at risk of developing atherosclerosis in medical diagnostic and sanatorium institutions.

Diseases of the cardiovascular system at the present stage are the leading cause of high disability and mortality in the world and in Russia (Chazov E.I., 2002; Oganov R.G., 2005). In this regard, the development of new effective methods for the prevention and correction of atherogenic disorders of lipid metabolism in individuals at risk of developing atherosclerosis is an urgent task for modern medicine.

The basis of primary and secondary prevention of cardiovascular diseases is the correction of the main risk factors - atherogenic disorders of lipid metabolism, high blood pressure, obesity, low physical activity. Disorders of lipid metabolism with high values of atherogenic lipids and lipoproteins with low levels of high density lipoproteins in blood plasma are a key link in the development of atherosclerosis and diseases of the circulatory system. It is also known that atherosclerosis in Russia develops at a younger age with severe complications, with frequent myocardial infarction and cerebral stroke in people younger than 50 years old (Olbinskaya L.I. et al., 2008).

The use of pharmacological agents with an effect on various links of lipid metabolism is an effective method for the prevention of atherosclerosis, but at the same time they are unsafe, have side effects and complications, and are not always accessible to the general population, which requires the search for new non-pharmacological methods.

Natural and preformed healing factors have been widely recognized as an important reserve for increasing the effectiveness of the treatment of many diseases. In recent years, data have been obtained confirming the important role of physical training, preformed physical factors, and balneological methods of influencing the correction of modifiable factors for the occurrence of atherosclerosis (V. Frolkov et al., 2007).

A known method for the prevention of dyslipidemia in children, characterized in that to achieve normalization of the lipid spectrum using the method of adaptation to intermittent hypobaric hyperbaric hypoxia in combination with the use of a 15% aqueous solution of dimephosphone at a dose of 30 mg / kg, i.e. 10-15 ml 3 times a day throughout the course of adaptation (22-25 sessions) [patent RU 2121329, 1998].

A known method for correcting lipid metabolism disorders in patients with neuro-endocrine syndrome, including mineral baths, gynecological irrigation with mineral water, carbon dioxide-hydrocarbonate-sulfate sodium-calcium low or medium mineralization - 3.1-3.8 g / l, temperature 36-38 ° FROM. The exposure of each procedure is 15 minutes. On a course of 8-12 procedures. Baths and gynecological irrigation are combined with an internal intake of mineral water 3 times a day 30-60 minutes before meals [patent RU 2236833, 2004].

There is a method of correcting lipid metabolism disorders, which includes a diet, dosed physical activity and the use of biologically active food additives "Timarin" in a dose of 5 ml 2 times a day before meals with monthly courses for 21 days [patent RU 2337696, 2008]. The method allows, by inhibiting the synthesis of cholesterol in hepatocytes and stimulating the synthesis of bile acids by hepatocytes (through an increase in the delivery of cholesterol in high-density lipoproteins), to improve the lipid profile with normalization of oxidative status.

A known method for correcting lipid metabolism and lipid peroxidation is that lycopene is administered in a daily dose of 10 mg once a night [patent RU 2392930, 2010]. The method provides the normalization of cholesterol levels and lipid peroxidation with a decrease in dose and frequency of drug administration by taking into account the circadian rhythm of lipid metabolism.

A known method for the correction of atherogenic lipid metabolism disorders in individuals at risk of developing atherosclerosis using dietary supplements and physical factors (magnetotherapy and hyperbaric oxygenation) (Karpukhin A.V. Development of non-pharmacological methods of restorative correction of lipid metabolism in individuals with a risk of developing atherosclerosis. ... candidate of medical sciences - M., 2010 .-- 27 s). Patients at the Chernaya Rechka cardiac medicine center (St. Petersburg) were prescribed dietary supplements with antioxidant activity: vetoron 5 ml 3 times a day for 14 days, lovsin 2 capsules in the morning, oxina 1 capsule in the morning and in the evening, gonsin 100 ml infusion inside the morning and evening. The apparatus “Aurora MK-01” was used to conduct magnetotherapy, using a pulsed traveling magnetic field with a magnetic induction intensity of 2.0–5.0 mT, a pulse repetition rate of 10–20 Hz, and an exposure time of 30 minutes. The course of magnetotherapy included 10 sessions, conducted with a break for 2 days off after the fifth procedure. Hyperbaric oxygenation sessions were carried out in the MPC 2U pressure chamber, where 100% oxygen was supplied under a pressure of 1 atm. The compression and decompression times were 15 minutes. The duration of one HBO procedure was 40 minutes. The course exposure included 10 daily sessions. The above method is not effective enough, since it does not provide for the maximum individualization of treatment, the effect on the main links of the pathogenetic mechanism of the development of atherosclerosis.

The prototype of the invention is a method for correcting lipid metabolism disorders in patients with diabetes mellitus, including the administration of the ascorutin antioxidant at a dose of 100 mg three times a day, together with the ingestion of carbonic sodium hydrogen chloride mineral water for 30 days [patent RU 2157692, 2000] .

Promising in relation to the possibility of correcting atherogenic disorders of lipid metabolism are the use of herbal remedies, natural koumiss, as well as drinking mineral waters, which can cause a complex of adaptive changes in regulatory systems in the body.

One of the non-pharmacological methods used in the sanatorium therapy of many diseases in Bashkiria is a natural therapeutic product - natural koumiss from mare's milk. Despite its widespread use in sanatorium practice, the possibility of using, as well as the therapeutic effects of this unique product in people at risk of developing atherosclerosis is still not disclosed.

A fundamentally new way to correct lipid metabolism in people at risk of developing atherosclerosis is the use of a treatment complex using koumiss.

Koumiss is a healing fermented milk drink of the nomadic peoples of the East, a valuable dietary and therapeutic product containing the optimal amount of vitamins, trace elements, antibiotic substances, lactic acid bacteria, necessary factors of cellular and humoral immunity, steroid and thyroid hormones. The main nutritional components of koumiss are absorbed almost completely (up to 95%). Koumiss is a rich source of essential amino acids, especially lysine, tryptophan, methionine, the deficiency of which in plant proteins can be covered by these amino acids of koumiss during its therapeutic use. Amino acids of koumiss have a leading role in the normalization of disturbed metabolic processes due to their participation in the construction of immune proteins, as well as in many biological and physiological processes of the body. The research results indicate that koumiss contains not only lipase, but also other proteolytic enzymes (proteases, catalases, reductases), which are involved in the breakdown of proteins, carbohydrates and fats, enhance redox processes. After koumiss treatment, the pigment, antitoxic, protein and carbohydrate functions of the liver are normalized. Observations of researchers have shown that the use of koumiss is effective in atherosclerosis. This effect is explained by the content of lipotropic substances in koumiss. A decrease in headaches, normalization of the pulse, improvement of metabolic processes in the myocardium by ECG dynamics were noted. Positive shifts are occurring on the part of protein fractions of the blood and the content of cholesterol, lipoproteins, potassium and sodium in the blood. Such a high efficiency of koumiss therapy is associated with the content of vitamins, enzymes, trace elements and lipotropic substances in koumiss. It was established that course koumiss treatment in sanatorium conditions improves the functional state of blood vessels in patients with angina pectoris, contributes to positive changes in clinical and hemodynamic parameters and increases the physical performance of patients. Antioxidant effects are due to the activation of antioxidant enzymes under the influence of polyunsaturated fatty acids (linoleic and linolenic) contained in koumiss, which also inhibit the oxidative modification of LDL.

It is known that some mineral waters (MB) can activate the regulation of lipid metabolism, positively affect hemodynamics in individuals at risk of developing atherosclerosis (Georgiadi-Avdinko K.A. et al., 2005; Frolov V.K. et al., 2005) .

Along with this, there are other approaches to solving the problem of correction of lipid metabolism in individuals with a risk of developing atherosclerosis using natural healing factors - phytochemicals. They contain a wide range of active substances that are metabolically close to the body, restore metabolic processes, and increase the nonspecific resistance of the body (Zaitsev L.M., 2009; Kropachev V.Yu., 2009).

The objective of the invention is to develop a method for the correction of atherogenic disorders of lipid metabolism in individuals at risk of developing atherosclerosis using natural healing factors - herbal remedies, koumiss and bicarbonate sulfate-calcium mineral water, which can influence the main pathogenesis of this pathology.

The technical result of the proposed method is to improve lipid metabolism, lipid peroxidation processes, antioxidant protection, increase exercise tolerance.

The proposed method is carried out as follows: against the background of basic sanatorium treatment, vacationers with a risk of developing atherosclerosis (in the Tanyp sanatorium of the Republic of Bashkortostan) receive koumiss of weak and medium strength with a constant acidity of 71-100 ° according to Turner 200-250 ml three times for 15- 20 minutes before eating. Use koumiss from mare’s milk with sourdough based on the microorganisms Lactobacterium bulgaricum and yeast type Torula, the duration of the exposure 24 days.

As an herbal remedy, use the herbal infusion “Doe”, containing oregano, horsetail, sweet clover, St. John's wort, and mountain pepper; rhizomes with peony roots; fruits of mountain ash, rose hips, hawthorn, chokeberry chokeberry; thallus kelp; flax seeds; immortelle flowers; licorice root in certain proportions (produced by Herbs of Bashkiria LLC in the form of a filter bag) in an amount of 200 ml 2 times a day, with a 24-day exposure course.

In addition, they prescribe the intake of mineral water “Kazanchinskaya” of the sanatorium “Tanyp” - low-mineralized hydrocarbonate sulfate calcium-magnesium composition (mineralization - 1.44 g / l). MB is used in the calculation of 3-4 ml per 1 kg of body weight three times a day for 15-20 minutes before meals, the duration of the course of exposure is 24 days.

Basic sanatorium treatment includes a lipid-lowering diet, physiotherapy exercises, walking outdoors, climatotherapy.

The proposed method was used in 119 men with a risk of developing atherosclerosis, laboratory signs of impaired lipid metabolism (cholesterol ≥ 5.2 mmol / l), without clinical signs of atherosclerosis at the age of 49.2 ± 1.3 years, who were in the sanatorium “Tanyp” of the Republic of Bashkortostan . Depending on the intervention, persons with a risk of developing atherosclerosis are divided into groups. The first group consisted of 57 patients who received the basic complex (comparison group). The second group (main) included 62 patients with a risk of developing atherosclerosis, who, against the background of the basic complex, took koumiss, phytocomplex “Doe”, low-mineralized hydrocarbonate sulfate-calcium mineral water according to the developed technique.

Koumiss of weak and medium strength with constant acidity of 71-100 ° according to Turner was taken 200-250 ml three times before meals. Koumiss was used from mare's milk with starter culture based on the microorganisms Lactobacterium bulgaricum and yeast type Torula. The course lasts 24 days. Herbal collection "Doe" was taken one package 2 times a day, the duration of the exposure 24 days. Mineral water "Kazanchinskaya" sanatorium "Tanyp" - low-mineralized hydrocarbonate sulfate calcium-magnesium composition (M - 1.44 g / l) was prescribed at the rate of 3-4 ml per 1 kg of body weight three times a day for 15-20 minutes before meals , the duration of the course of exposure is 24 days.

The basic complex included a lipid-lowering diet, exercise therapy and walking outdoors, climatotherapy.

Before starting treatment, all vacationers underwent clinical, laboratory and instrumental studies. Determination of concentrations of total cholesterol (OXC), triglycerides (TG), high density lipoprotein cholesterol (HDL cholesterol), low density plasma lipoprotein cholesterol (LDL cholesterol), atherogenic coefficient (KA), primary and secondary products of lipid peroxidation (LPO) in blood plasma, antioxidant system activity. Electrocardiography was conducted, a study of the individual tolerance of patients to physical activity.

As a result of the course of sanatorium exposure using koumiss, phytobarrow and bicarbonate calcium sulphate MB, a significant decrease in total cholesterol was found in comparison with the initial values by 13.09% (p <0.05), and the level of TG - by 12.32% (p < 0.05), LDL cholesterol - by 14.46% (p <0.05). At the same time, a slight increase in HDL cholesterol was observed - by 6.63%. The ratio of LDL cholesterol / HDL cholesterol decreased in relation to the initial data by 13.75% (p <0.05) with less significant biases in the comparison group. The ratio of LDL cholesterol / HDL cholesterol significantly decreased relative to the outcome by 19.62% (p <0.05) (Table 1). In the comparison group, deviations in the blood lipid spectrum were insignificant. Changes in the parameters of the lipid profile indicate that koumiss has a lipid-lowering effect due to increased lipid catabolism under the influence of koumiss, which contributes to the intensification of redox reactions in the body, which also has lipase and amylase activity, which was previously proved in experimental and clinical studies (Shaykhiev A.A. ., 1996).

When discharged from the sanatorium, persons receiving koumiss, phytocomplex, and MB showed a significant decrease in the content of primary and secondary LPO products. The level of diene conjugates after course use of koumiss is lower than the initial data by 20.25% (p <0.05), ketodienes and conjugated trienes - by 28.86% (p <0.05), malondialdehyde - by 21.17% ( p <0.05) from the original. The shift in the parameters of peroxide metabolism in the comparison group was insignificant (Table 2).

The use of koumiss, phytocomplex, and MB revealed an increase in total antioxidant activity (OAA) by 12.8% (p <0.05), superoxide dismutase (SOD) - by 10.8% (p <0.05), catalase - by 9.1% (p <0.05) relative to the initial values. In the comparison group, the parameter shifts were insignificant (Table 3).

The antioxidant effects of koumiss are primarily associated with direct exposure to koumiss ingredients, such as vitamin C and E, polyunsaturated fatty acids, carotene, the antioxidant activity of which has been previously proved in experimental and clinical studies. One of the probable mechanisms for increasing the activity of antioxidant enzymes against the background of koumiss may be elimination of the inhibitory effect of lipid peroxidation on the functional state of the catalytic center of enzymes (Valiev A.G., 2001; Gilmutdinova L.T. et al., 2004).

Shifts in the parameters of the lipid profile indicate that koumiss, phyto-collection “Doe” have a lipid-lowering effect, probably due to increased lipid catabolism under the influence of koumiss, which contributes to the intensification of redox reactions in the body, which also has lipase and amylase activity (Shaikhiev A.A., 1996). And mineral water enhances lipid catabolism and improves redox reactions in the body, contributes to a more significant dynamics of the parameters of the lipid spectrum.

The intake of koumiss, the Doe phytocomplex and MB contributed to an increase in exercise tolerance, the amount of work performed, the threshold load capacity and double product values in people at risk of developing atherosclerosis, noted both at discharge from the sanatorium and after 3 months of observation. The results of VEM showed unidirectional dynamics of indicators in the comparison group. Tolerance to physical activity in the main group increased by 11.6% (p <0.05), in the comparison group - by 4.2%.

The use of koumiss, phyto-collection "Doe" and MB was not accompanied by serious side effects. There were no significant changes in the levels of glucose, bilirubin, blood creatinine.

Thus, the use of non-pharmacological agents such as koumiss and the phytocomplex “Doe” in combination with bicarbonate sulfate-calcium magnesium weakly mineralized MB in individuals with atherogenic disorders of lipid metabolism has a corrective effect on lipid metabolism with a decrease in the level of atherogenic lipids, an increase in the level of HDL cholesterol, and inhibition of LP processes. and increased activity of antioxidant enzymes, increases exercise tolerance.

In the available scientific, medical and patent literature, there is information about the popularity of the method of correction of lipid metabolism in people at risk of developing atherosclerosis, characterized in that, against the background of basic sanatorium treatment, weak and medium strength koumiss with constant acidity of 71-100 ° according to Turner 200-250 is used ml three times a day for 15-20 minutes before meals, the herbal infusion of “Doe” in an amount of 200 ml 2 times a day in combination with bicarbonate sulfate-calcium magnesium mineralized mineral water at the rate of 3-4 ml per 1 kg la three times a day for 15-20 minutes before eating, while the duration of the course of exposure is 24 days, not detected. Thus, the claimed invention meets the criterion of "novelty."

The authors' studies proved that the use of weak and medium strength with a constant acidity of 71-100 ° according to Turner 200-250 ml three times a day for meals 15-20 minutes before a meal, against the background of basic sanatorium treatment, the infusion of herbal collection “Doe” in the amount of 200 ml 2 times a day in combination with bicarbonate sulfate-calcium magnesium weakly mineralized mineral water at the rate of 3-4 ml per 1 kg of body weight three times a day 15-20 minutes before meals, the duration of the course of exposure is 24 days, provides a corrective effect on lipid exchange with the reduction of atherogenic lipid levels, increasing HDL cholesterol levels, inhibition of lipid peroxidation processes, increase in the activity of antioxidant enzymes, increases exercise tolerance. Thus, the claimed invention meets the criterion of "inventive step".

The proposed method is illustrated by the following clinical examples.

Example 1. Patient P., 45 years old, was admitted to the sanatorium "Tanyp" with a diagnosis of Dyslipidemia. According to laboratory data, atherogenic dyslipidemia was detected: total cholesterol - 6.11 mmol / l, TG - 2.19 mmol / l, LDL cholesterol - 3.8 mmol / l, HDL cholesterol - 1.19 mmol / l, atherogenicity index (CA ) - 3.16 rel. Indicators of LPO processes: the level of diene Kenyugates (DC) - 4.69 units / ml, cotodions (CD) and conjugated trienes (ST) - 2.91 units / ml, malondialdehyde (MDA) - 3.07 μmol / ml.

Indicators of the antioxidant system of blood plasma: total antioxidant activity (OAA) - 26.44%, superoxide dismutase (SOD) - 2.79 conventional units / ml, catalase - 15.6 ml.cat / l.

According to the bicycle ergometric test, exercise tolerance is 68.9 watts.

The basic complex included a lipid-lowering diet, exercise therapy and walking outdoors, climatotherapy.

Correction of lipid metabolism was carried out according to the claimed method, against the background of the base complex was used koumiss, phyto-collection "Doe" in combination with bicarbonate sulfate-calcium magnesium low mineralization MB. We used koumiss of weak and medium strength with constant acidity of 71-100 ° according to Turner 200-250 ml three times a day for 15-20 minutes before meals, the duration of the course of exposure is 24 days. Infusion of phyto collection “Doe” in an amount of 200 ml 2 times a day with a 24-day exposure course and mineral water “Kazanchinskaya” of the sanatorium “Tanyp” - low-mineralized hydrocarbonate sulphate calcium-magnesium composition (M - 1.44 g / l) at the rate of 3- 4 ml per 1 kg of body weight three times a day for 15-20 minutes before meals, the duration of the course of exposure is 24 days.

As a result of the course of sanatorium treatment, the level of cholesterol decreased to 5.31 mmol / L, TG to 1.92 mmol / L, LDL cholesterol to 3.25 mmol / L, CA to 2.54 rel.ed with an increase in HDL cholesterol to 1 , 28 mmol / L. Indicators of LPO processes: the level of DC decreased to 3.74 units / ml, cotodions (CD) and CT to 2.07 units / ml, MDA to 2.42 μmol / ml. A positive effect on the parameters of the antioxidant system of blood plasma was noted: OAA - 30.80%, SOD - 3.19 conventional units / ml, catalase - 17.38 ml.cat./L. According to the bicycle ergometric test, exercise tolerance increased to 78.9 watts.

Example 2. Patient K., 47 years old, was admitted to the sanatorium "Tanyp" with a diagnosis of Dyslipidemia. According to laboratory data, atherogenic dyslipidemia was detected: OXS - 6.09 mmol / L, TG - 2.20 mmol / L, LDL cholesterol - 3.82 mmol / L, HDL cholesterol - 1.29 mmol / L, atherogenic index (CA ) - 3.20 rel. Indicators of LPO processes: the level of diene conjugates (DC) -4.71 units / ml, ketodiones (CD) and conjugated trienes (CT) - 2.90 units / ml, malondialdehyde (MDA) - 3.08 μmol / ml. Indicators of the antioxidant system of blood plasma: total antioxidant activity (OAA) - 26.42%, superoxide dismutase (SOD) - 2.78 conventional units / ml, catalase - 15.61 ml.cat / l. According to the bicycle ergometry test, exercise tolerance is 69.9 watts.

The basic complex included a lipid-lowering diet, exercise therapy and walking outdoors, climatotherapy.

Correction of lipid metabolism was carried out according to the claimed method, against the background of the base complex was used koumiss, phyto-collection "Doe" in combination with bicarbonate sulfate-calcium magnesium low mineralization MB. We used koumiss of weak and medium strength with constant acidity of 71-100 ° according to Turner 200-250 ml three times a day for 15-20 minutes before meals, the duration of the course of exposure is 24 days. Infusion of phyto collection “Doe” in an amount of 200 ml 2 times a day with a 24-day exposure course and mineral water “Kazanchinskaya” of the sanatorium “Tanyp” - low-mineralized hydrocarbonate sulphate calcium-magnesium composition (M - 1.44 g / l) at the rate of 3- 4 ml per 1 kg of body weight three times a day for 15-20 minutes before meals, the duration of the course of exposure is 24 days.

As a result of the course of sanatorium treatment, the level of cholesterol decreased to 5.30 mmol / L, TG to 1.79 mmol / L, LDL cholesterol to 3.24 mmol / L, SC to 2.52 rel.ed with an increase in HDL cholesterol to 1 , 29 mmol / l. Indicators of LPO processes: the level of DC decreased to 3.72 units / ml, CD and CT to 2.04 units / ml, MDA to 2.41 μmol / ml. A positive effect on the parameters of the antioxidant system of blood plasma was noted: OAA - 29.91%, SOD - 3.2 srvc / ml, catalase - 17.25 ml.kat / l. According to the bicycle ergometric test, exercise tolerance increased to 80.1 watts.

The proposed method is easily reproducible in the conditions of medical diagnostic and sanatorium institutions. Thus, the claimed invention meets the criterion of "industrial applicability".

Table 1 The dynamics of lipid metabolism in people at risk of developing atherosclerosis while taking koumiss, phytocomplex, and MB (M ± m) Groups The main group (n = 62) Comparison Group (n = 57) Indicators before treatment after treatment before treatment after treatment OHS, mmol / l 6.11 ± 0.10 5.31 ± 0.13 * 6.08 ± 0.11 5.87 ± 0.14 HDL cholesterol, mmol / l 1.20 ± 0.01 1.28 ± 0.01 * 1.21 ± 0.01 1.21 ± 0.02 LDL cholesterol mmol / l 3.82 ± 0.08 3.25 ± 0.12 * 3.81 ± 0.12 3.79 ± 0.10 TG, mmol / l 2.19 ± 0.07 1.92 ± 0.09 * 2.21 ± 0.03 2.14 ± 0.02 * - significance of differences in indicators before and after treatment, p <0.05

table 2 Dynamics of indicators of LPO processes in individuals at risk of developing atherosclerosis while taking koumiss, phytocomplex, and MB (M ± m) Groups The main group (n = 62) Comparison Group (n = 57) Indicators before treatment after treatment before treatment after treatment DC, u / ml 4.69 ± 0.11 3.74 ± 0.12 * 4.70 ± 0.08 4.60 ± 0.10 CD and CT, units / ml 2.91 ± 0.08 2.07 ± 0.05 * 2.89 ± 0.10 2.79 ± 0.08 MDA, μmol / L 3.07 ± 0.10 2.42 ± 0.08 * 3.08 ± 0.09 2.97 ± 0.10 * - significance of differences in indicators before and after treatment, p <0.05

Table 3 Dynamics of indicators of the antioxidant system of blood plasma in individuals at risk of developing atherosclerosis while taking koumiss, phytocomplex, and MB (M ± m) Indicators The main group (n = 62) Comparison Group (n = 57) before treatment after treatment before treatment after treatment OAA,% 26.44 ± 0.44 30.80 ± 0.41 * 26.43 ± 0.31 26.7 ± 0.40 SOD, Services.U / ml 2.79 ± 0.09 3.19 ± 0.11 * 2.77 ± 0.12 2.81 ± 0.10 Catalase, ml.kat / l 15.60 ± 0.21 17.38 ± 0.24 * 15.59 ± 0.20 15.90 ± 0.22 * - significance of differences in indicators before and after treatment, p> 0.05

Claims (1)

A method for correcting lipid metabolism in people at risk of developing atherosclerosis, including taking mineral water against the background of basic sanatorium treatment, characterized in that they additionally prescribe weak and medium strength koumiss with constant acidity of 71-100 ° according to Turner 200-250 ml three times a day , for 15-20 minutes before a meal, the infusion of phyto-collection “Doe” in an amount of 200 ml 2 times a day, and hydrocarbonate sulfate calcium-magnesium composition with a salinity of 1.44 g / l mineral water “Kazanchinskaya” is used as mineral water 3-4 m per 1 kg of body weight three times a day for 15-20 minutes before meals, with the duration of exposure is 24 days.