RU2483720C1 - Method of treating benign diseases of cervix - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to gynecology, and can be used for treatment of benign diseases of cervix. For this purpose rectal viferon suppositories are preliminarily introduced for ten days in dose 1000000 IU. After that, cervix is treated with solcovagin solution with 30-60 sec exposure 1-2 times during the day on the 5-7 day of the following menstrual cycle. After 4-5 days medication viferon is applied in form of gel on cervix in dose 1-2 applications per day, course length being 7-8 days.

EFFECT: method makes it possible to increase treatment efficiency due to certain successive combined application of mutually complementing each other as to mechanism of action medications, which leads to acceleration of healing process and provides etiopathogenic mechanism of treating benign diseases of cervix.

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Description

The invention relates to medicine, namely to gynecology, and can be used to treat benign diseases of the cervix uteri: inflammatory cervicitis, ectopia, pseudo-erosion, erosive ectropions.

A known method of treating pseudo-erosion of the cervix (RF patent No. 2217150) with a plasma-chemical nitric oxide stream for 30-60 seconds, followed by the application of the collagen sponge Sangvikol. The procedures are carried out 2 times a week. The total number of procedures is 8-10. Processing is performed by the Plazon air-plasma apparatus.

The use of a special rather complicated and expensive device complicates and increases the cost of the treatment process.

Electrocoagulation, cryodestruction, electroconization are widely used to treat this pathology. Their effectiveness is 55% (with electrotherapy), 65% (with cryotherapy), however, the disadvantages are that the destruction depth cannot be determined, tissue edema remains for a long time, cervical deformities of the cervix are noted, relapses are possible, which leads to low efficiency (Minkina G.N., S. Rusakevich. Diseases of the cervix. Minsk, 2000, p. 286, 260).

There is a method of treating benign diseases of the cervix uteri with solkovagin (M.N. Kostava Treatment of benign diseases of the cervix uteri with solkovagin // In the book: Diseases of the cervix, vagina, vulva // Edited by V.N. Prilepskaya. - M., 1999 . - S.178-183), selected as a prototype.

Solkovagin is a mixture of: nitric acid 70%, acetic acid 99%, oxalic acid digitrate, zinc nitrate hexahydrate, distilled water. A cotton swab dipped in a solution of solkovagin is applied within a healthy tissue. In this case, a white or yellow scab is immediately formed. After 2-3 minutes, the solovagin is applied to the already formed scab. The scab is rejected on the 3-5th day bloodless and painlessly. By the 9th day from the moment of coagulation, epithelization occurs. If during the control colposcopic examination on the 9-10th day from the moment of coagulation, partial epithelization is noted, reapply. The patient is again examined after 14 days and in the absence of epithelization, the 3rd and 4th applications are performed.

The method is characterized by low efficiency (75%). Relapse in the treatment of solkovagin is noted in 10-25% of cases.

The objective of the invention is to increase the effectiveness of the treatment of benign diseases of the cervix.

The problem is solved by a method of treating benign diseases of the cervix uteri, which consists in the fact that prior to ten days the patient is injected rectal viferon suppositories in a dose of 1,000,000 ME, then on the 5-7 day of the next menstrual cycle, the vaginal part of the cervix is treated with a solution of solovagin with an exposure of 30 -60 sec 1-2 times during the day, after 4-5 days, Viferon is applied to the cervix in the form of a gel of 1-2 applications per day daily, for a course of 7-8 days.

A distinctive feature of the method according to the invention is the sequential combined use of drugs that are mutually complementary in terms of the mechanism of action, which leads to an acceleration of the healing process and provides an etiopathogenetic mechanism for the treatment of benign diseases of the cervix.

The method is as follows.

Sexually transmitted infections are screened. Before starting the procedure, the cervix is exposed in the mirrors, the vaginal mucus is removed with a cotton swab and an extended colposcopy is performed to more clearly visualize the borders of the lesion.

Previously, in the second phase of the menstrual cycle, for ten days daily, the drug is treated with viferon rectal suppositories in a dose of 1,000,000 ME, 1 suppository 2 times a day.

On the 5-7th day of the next menstrual cycle, the surface of the vaginal part of the cervix is treated with a solution of solkovagin with an exposure of 30-60 seconds. After 1-2 minutes, the treatment with the solution of solkovagin is repeated to enhance the therapeutic effect.

After 4-5 days, the drug Viferon in the form of a gel is applied to the cervix by applying a thin layer to the areas of the affected cylindrical epithelium 1-2 times a day daily for 7-8 days. The course dose of the drug is about 20.0 g, depending on the area of the affected surface of the stratified squamous epithelium of the vaginal part of the cervix.

A control examination is carried out 3 months after the treatment procedure, and if necessary, control tests are performed for sexually transmitted infections.

We give specific examples of the method.

Example 1

Patient M., 25 years old. A history of 1 pregnancy (1 birth - caesarean section for 42 weeks after stimulation of labor). Polycystic ovary, ovarian dysfunction from 14 years. On examination, revealed chronic endocervicitis, ectopia. Adhesive process in the pelvic cavity. The neck is conical in shape. Reconstruction of both spouses. In the history of ureaplasmosis, gardnerellosis was treated. At the control examination for infection, the analysis is negative. Colposcopy revealed a picture of chronic endocervicitis. Recommended sexual rest.

A patient in the second phase of the menstrual cycle for 10 days daily is treated with viferon rectal suppositories in a dose of 1,000,000 ME, 1 suppository 2 times a day. On the 5th day of the next menstrual cycle, a woman is invited to the treatment procedure with a solution of solkovagin. The cervix is naked in the mirrors, treated with a dry cotton swab. After extensive colposcopy, a thin swab soaked in a solution of solkovagin was introduced onto the surface of the mucous membrane of the vaginal part of the cervix. The application was performed at 3, 6, 9, 12 hours with an exposure of 30-60 seconds. After 2 minutes, the treatment with the solkovagin solution was repeated with an exposure time of 30-60 seconds. After the procedure, the neck was not processed by anything. The woman was on the chair for 10 minutes. Mirrors removed. It was recommended that any vaginal interventions be excluded.

After 5 days under aseptic conditions after exposure of the cervix in the patient’s mirrors, the drug was applied with Viferon-gel by application of a thin layer on the sections of the affected cylindrical epithelium at 3, 6, 9, 12 hours. The patient received 7 applications of viferon-gel with an interval of 24 hours.

Sexual life is allowed through two menstruation.

A follow-up examination after 3 months did not reveal a pathology of the cervix.

Example 2

Patient Ch., 20 years old. There was no pregnancy history. Of somatic diseases, NDC is a mixed type. Menses from 14 years, 7 days, after 28 days. Since 2011, there has been a violation of the menstrual cycle. In 2011, she suffered acute salpingoophoritis. Clinical and instrumental examination revealed polycystic ovaries, pseudo-erosion of the cervix. The cervix is conical in shape. Examined for intracellular infections, the result is negative. According to colposcopy, a picture of the ectopia of the vaginal part of the cervix was revealed. Recommended sexual rest.

The patient in the second phase of the menstrual cycle for 10 days daily was treated with viferon rectal suppositories in a dose of 1,000,000 ME, 1 suppository 2 times a day. On the 5th day of the next menstrual cycle, the woman was invited to the treatment procedure with a solution of solkovagin. The cervix is exposed in aseptic conditions in the mirrors, treated with a dry cotton swab. After extensive colposcopy, a thin swab soaked in a solution of solkovagin was introduced onto the surface of the mucous membrane of the vaginal part of the cervix. The application was performed at 9 and 12 hours with an exposure of 30-60 seconds. After 2 minutes, the treatment with the solution of solkovagin was repeated for 30-60 seconds. After the procedure, the neck was not processed by anything. The woman was on the chair for 10 minutes. Mirrors removed. It was recommended that any vaginal interventions be excluded.

After 5 days, the patient was applied the viferon-gel preparation by application of a thin layer on the areas of the affected cylindrical epithelium. The patient received 7 applications of viferon-gel with an interval of 24 hours. Sexual life is allowed through two menstruation. A follow-up examination after 3 months did not reveal a cervical pathology.

This method treated 30 patients. The effectiveness of the treatment is 85%.

The method according to the invention increases the effectiveness of treatment due to the sequential combined use of drugs that are mutually complementary in terms of the mechanism of action, which leads to an acceleration of the healing process and provides an etiopathogenetic mechanism for the treatment of benign diseases of the cervix.

Claims (1)

A method for the treatment of benign diseases of the cervix uteri, which consists of first injecting rectal viferon suppositories at a dose of 1,000,000 ME for ten days, then treating the cervix with an exposure of solkovagin with an exposure time of 30-60 s 1-2 for 5-7 days of the next menstrual cycle times during the day, after 4-5 days, the drug Viferon is applied to the cervix in the form of a gel of 1-2 applications per day for a course of 7-8 days.