SU1572624A1 - Method of treating hyperplastic processes of endometrium - Google Patents

Abstract

This invention relates to gynecology. For this, a 12.5% solution of hydroxyprogesterone capronate is administered intrauterinely and the pathologically changed endometrium is simultaneously affected by low-frequency ultrasound in a pulsed mode with a frequency of 22.4 ± 4.4 kHz, an amplitude of 2 µm for 3 minutes. This makes it possible to lengthen the term of remission and reduce the number of relapses of the disease.

Description

This invention relates to the field of medicine, namely gynecology.

The purpose of the invention is to reduce the number of relapses.

The method of treatment is carried out as follows.

The patient is placed in a gynecological chair. External genitals are treated with an antiseptic solution. Expose and treat antiseptic cervix. 500 mg of a 12.5% solution of hydroxyprogesterone capronate are injected into the uterine cavity through the cervical canal, then the tip of the ultrasonic applicator is inserted and voiced by low-frequency ultrasound in a pulse mode of 22.4 ± 4.4 kHz with an amplitude of 2 µm for 3 minutes. In the course of three treatments daily or every other day.

Example 1. Ill L., 48 years old. He complained of recurrent, long-term irregular, bloody discharge from the genital tract.

He considers himself a patient for about 3 years, when he was first diagnosed with copious bloody discharges from the genital tract by the type of metrorrhagia. For therapeutic and diagnostic purposes, separate curettage of the uterus was performed.

Bleeding has stopped. The result of histological examination of scrapings - glandular hyperplasia of the endometrium. She was prescribed therapy with synthetic progestins (bi-securin) using a contraceptive regimen. In the course of treatment, the menstrual function normalized: the monthly became regular, moderate, for 4-5 days. By the end of the third month of treatment with synthetic progestins, the patient complained of pain and hardening along the saphenous veins of both lower limbs. Treatment discontinued. For 1.5 years, the menstrual function did not change: monthly after 27 days for 4-5 days, moderate painful in the first days. Then, after the absence of menstruation for 5 months, abundant bleeding from the genital tract began. The uterus was scraped. The data of histological examination of scraping - glandular-cystic hyperplasia of the endometrium. Oxyprogesterone capronate was treated with 250 mg 2 times in the second phase of the menstrual cycle. After 2 cycles, the patient arbitrarily stopped the prescribed treatment.

Over the past year there have been periodic bleedings of the type

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meno- and metrorrhagia. A histological study of the endometrium conducted a month ago was glandular hyperplasia of the endometrium.

At vaginal examination: the cervix is cylindrical, hypertrophied without visible pathology. The body of the uterus is retroflex, dense, restrictedly mobile, slightly enlarged, sensitive to palpation. The appendages on both sides are not detected, their area is painless. The vaults are deep, parameters are free. Blood discharge is moderate.

General analysis of blood, urine, discharge - within the acceptable physiological norms. Blood sugar 5.66 mmol / l

Cytological examination of aspirate from the uterus - a picture of glandular hyperplasia of the endometrium.

The treatment by the proposed method was performed at an interval of 1 day, three sessions of intrauterine phonophoresis of oxyprogesterone capronate were performed. After the treatment, two menstrual periods were noted, after which the monthly ones stopped. At aspiration biopsy of the endometrium after 6 months - the state of atrophy.

The proposed method conducted 3 sessions of phonophoresis of hydroxyprogesterone capronate (daily). The next menstruation took place with a delay of 6 days, not abundant. In the course of monitoring the patient for 5 months, menstrual disorders were not observed.

The proposed method allows reducing the number of relapses in 93% of patients as compared with the known method (74.6%).

Claims (1)

Invention Formula A method for treating endometrial hyperplastic processes by administering hydroxyprogesterone capronate, characterized in that, in order to reduce the number of relapses, hydroxyprogesterone capronate is administered intrauterinely and simultaneously affected by low-frequency ultrasound in a pulsed mode for 3 minutes.