RU2478094C2 - Замещенные n-фенил-бипирролидинмочевины и их терапевтическое применение - Google Patents
Замещенные n-фенил-бипирролидинмочевины и их терапевтическое применение Download PDFInfo
- Publication number
- RU2478094C2 RU2478094C2 RU2010119554/04A RU2010119554A RU2478094C2 RU 2478094 C2 RU2478094 C2 RU 2478094C2 RU 2010119554/04 A RU2010119554/04 A RU 2010119554/04A RU 2010119554 A RU2010119554 A RU 2010119554A RU 2478094 C2 RU2478094 C2 RU 2478094C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- bipyrrolidinyl
- phenyl
- carboxylic acid
- amide
- Prior art date
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
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- Urology & Nephrology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060607P | 2007-10-17 | 2007-10-17 | |
| US60/980,606 | 2007-10-17 | ||
| PCT/US2008/079763 WO2009052068A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010119554A RU2010119554A (ru) | 2011-11-27 |
| RU2478094C2 true RU2478094C2 (ru) | 2013-03-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010119554/04A RU2478094C2 (ru) | 2007-10-17 | 2008-10-14 | Замещенные n-фенил-бипирролидинмочевины и их терапевтическое применение |
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| EP (1) | EP2215058B1 (enExample) |
| JP (1) | JP5380455B2 (enExample) |
| KR (1) | KR20100082349A (enExample) |
| CN (1) | CN101903341B (enExample) |
| AT (1) | ATE534625T1 (enExample) |
| AU (1) | AU2008312641A1 (enExample) |
| CA (1) | CA2702933C (enExample) |
| CY (1) | CY1112391T1 (enExample) |
| DK (1) | DK2215058T3 (enExample) |
| ES (1) | ES2378011T3 (enExample) |
| HR (1) | HRP20120166T1 (enExample) |
| IL (1) | IL205002A0 (enExample) |
| MA (1) | MA31889B1 (enExample) |
| MX (1) | MX2010003948A (enExample) |
| MY (1) | MY148807A (enExample) |
| NZ (1) | NZ584692A (enExample) |
| PL (1) | PL2215058T3 (enExample) |
| PT (1) | PT2215058E (enExample) |
| RS (1) | RS52221B (enExample) |
| RU (1) | RU2478094C2 (enExample) |
| SI (1) | SI2215058T1 (enExample) |
| WO (1) | WO2009052068A1 (enExample) |
| ZA (1) | ZA201002114B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2212282T1 (sl) * | 2007-10-17 | 2012-01-31 | Sanofi Sa | Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba |
| DK2212283T3 (da) | 2007-10-17 | 2011-12-19 | Sanofi Sa | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf |
| EP2205558B1 (en) * | 2007-10-17 | 2012-07-25 | Sanofi | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
| WO2009151203A1 (ko) * | 2008-06-13 | 2009-12-17 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
| US10412788B2 (en) | 2008-06-13 | 2019-09-10 | Lg Chem, Ltd. | Heating element and manufacturing method thereof |
| KR20090129927A (ko) | 2008-06-13 | 2009-12-17 | 주식회사 엘지화학 | 발열체 및 이의 제조방법 |
| AR081908A1 (es) | 2010-05-11 | 2012-10-31 | Sanofi Aventis | N-heteroaril-espirolactama-bipirrolidinas sustituidas, preparacion y usos terapeuticos de las mismas |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| JP2013526530A (ja) * | 2010-05-11 | 2013-06-24 | サノフイ | 置換されたｎ−フェニルスピロラクタムビピロリジン、その製造及び治療上の使用 |
| AR081034A1 (es) | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
| EP2569294B1 (en) * | 2010-05-11 | 2015-03-11 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| WO2011143161A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| SG10202010119TA (en) | 2010-11-15 | 2020-11-27 | Abbvie Inc | NAMPT And Rock Inhibitors |
| EA023260B1 (ru) * | 2011-02-23 | 2016-05-31 | Сувен Лайф Сайенсиз Лимитед | Новые соединения в качестве лигандов гистаминовых h-рецепторов |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| RU2301231C2 (ru) * | 2000-10-17 | 2007-06-20 | Шеринг Корпорейшн | Полициклическое соединение, фармацевтическая композиция, обладающая свойствами антагониста рецептора h3, и способ лечения с его применением |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7279491B2 (en) * | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE602006010833D1 (de) | 2005-03-17 | 2010-01-14 | Lilly Co Eli | Pyrrolidinderivate als histamin-h3-rezeptorantagonisten |
| CN101151244B (zh) * | 2005-04-01 | 2014-09-03 | 伊莱利利公司 | 组胺h3受体活性剂、制备和治疗用途 |
| EP2322506A1 (en) * | 2005-07-01 | 2011-05-18 | Eli Lilly and Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| US7943605B2 (en) * | 2005-10-27 | 2011-05-17 | Ucb Pharma S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| SI2212282T1 (sl) | 2007-10-17 | 2012-01-31 | Sanofi Sa | Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba |
| EP2205558B1 (en) | 2007-10-17 | 2012-07-25 | Sanofi | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
| DK2212283T3 (da) | 2007-10-17 | 2011-12-19 | Sanofi Sa | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf |
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2008
- 2008-10-14 KR KR1020107010481A patent/KR20100082349A/ko not_active Ceased
- 2008-10-14 CA CA2702933A patent/CA2702933C/en not_active Expired - Fee Related
- 2008-10-14 PT PT08838702T patent/PT2215058E/pt unknown
- 2008-10-14 MX MX2010003948A patent/MX2010003948A/es active IP Right Grant
- 2008-10-14 PL PL08838702T patent/PL2215058T3/pl unknown
- 2008-10-14 EP EP08838702A patent/EP2215058B1/en active Active
- 2008-10-14 WO PCT/US2008/079763 patent/WO2009052068A1/en not_active Ceased
- 2008-10-14 AU AU2008312641A patent/AU2008312641A1/en not_active Abandoned
- 2008-10-14 DK DK08838702.2T patent/DK2215058T3/da active
- 2008-10-14 RS RS20120067A patent/RS52221B/sr unknown
- 2008-10-14 AT AT08838702T patent/ATE534625T1/de active
- 2008-10-14 ES ES08838702T patent/ES2378011T3/es active Active
- 2008-10-14 SI SI200830552T patent/SI2215058T1/sl unknown
- 2008-10-14 RU RU2010119554/04A patent/RU2478094C2/ru not_active IP Right Cessation
- 2008-10-14 HR HR20120166T patent/HRP20120166T1/hr unknown
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- 2008-10-14 CN CN2008801212096A patent/CN101903341B/zh not_active Expired - Fee Related
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- 2008-10-14 JP JP2010530054A patent/JP5380455B2/ja not_active Expired - Fee Related
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2010
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- 2010-03-25 ZA ZA2010/02114A patent/ZA201002114B/en unknown
- 2010-04-11 IL IL205002A patent/IL205002A0/en unknown
- 2010-05-17 MA MA32842A patent/MA31889B1/fr unknown
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2012
- 2012-02-23 CY CY20121100185T patent/CY1112391T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2301231C2 (ru) * | 2000-10-17 | 2007-06-20 | Шеринг Корпорейшн | Полициклическое соединение, фармацевтическая композиция, обладающая свойствами антагониста рецептора h3, и способ лечения с его применением |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2702933C (en) | 2012-12-18 |
| CA2702933A1 (en) | 2009-04-23 |
| ZA201002114B (en) | 2010-12-29 |
| HK1146056A1 (en) | 2011-05-13 |
| JP5380455B2 (ja) | 2014-01-08 |
| US20100173908A1 (en) | 2010-07-08 |
| ES2378011T3 (es) | 2012-04-04 |
| EP2215058B1 (en) | 2011-11-23 |
| MA31889B1 (fr) | 2010-12-01 |
| CN101903341B (zh) | 2012-10-03 |
| ATE534625T1 (de) | 2011-12-15 |
| HRP20120166T1 (hr) | 2012-03-31 |
| SI2215058T1 (sl) | 2012-03-30 |
| WO2009052068A1 (en) | 2009-04-23 |
| MY148807A (en) | 2013-05-31 |
| RS52221B (sr) | 2012-10-31 |
| PL2215058T3 (pl) | 2012-04-30 |
| AU2008312641A1 (en) | 2009-04-23 |
| RU2010119554A (ru) | 2011-11-27 |
| EP2215058A1 (en) | 2010-08-11 |
| JP2011500697A (ja) | 2011-01-06 |
| MX2010003948A (es) | 2010-04-30 |
| CN101903341A (zh) | 2010-12-01 |
| PT2215058E (pt) | 2012-03-06 |
| CY1112391T1 (el) | 2015-12-09 |
| DK2215058T3 (da) | 2012-03-12 |
| NZ584692A (en) | 2011-12-22 |
| IL205002A0 (en) | 2010-11-30 |
| US8222290B2 (en) | 2012-07-17 |
| KR20100082349A (ko) | 2010-07-16 |
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