RU2477720C2 - Замещенные n-фенилбипирролидинкарбоксамиды и их применение в лечебных целях - Google Patents
Замещенные n-фенилбипирролидинкарбоксамиды и их применение в лечебных целях Download PDFInfo
- Publication number
- RU2477720C2 RU2477720C2 RU2010119528/04A RU2010119528A RU2477720C2 RU 2477720 C2 RU2477720 C2 RU 2477720C2 RU 2010119528/04 A RU2010119528/04 A RU 2010119528/04A RU 2010119528 A RU2010119528 A RU 2010119528A RU 2477720 C2 RU2477720 C2 RU 2477720C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- bipyrrolidinyl
- phenyl
- amide
- carboxylic acid
- Prior art date
Links
- FZDBXPMUZILHON-KGJQWSFPSA-N CC(CCC1)N1C(CC1)CN1c(c(C)c1)c(C)cc1NC(C1[C@@H](CC2)C[C@@H]2C1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(c(C)c1)c(C)cc1NC(C1[C@@H](CC2)C[C@@H]2C1)=O FZDBXPMUZILHON-KGJQWSFPSA-N 0.000 description 1
- WXTBOKJYHOLEFC-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(C1C(C)(C)C1(C)C)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)c(C)cc1NC(C1C(C)(C)C1(C)C)=O WXTBOKJYHOLEFC-UHFFFAOYSA-N 0.000 description 1
- UFDQJRUQADOLSZ-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1NC(c1cc(-c2ccncc2)n[nH]1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)cc(C)c1NC(c1cc(-c2ccncc2)n[nH]1)=O UFDQJRUQADOLSZ-UHFFFAOYSA-N 0.000 description 1
- RCUFJSPQSAHGNP-UHFFFAOYSA-N CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c1n[nH]c(C)c1)=O Chemical compound CC(CCC1)N1C(CC1)CN1c(cc1)ccc1NC(c1n[nH]c(C)c1)=O RCUFJSPQSAHGNP-UHFFFAOYSA-N 0.000 description 1
- CJJRTJUBMZIMQU-HKUYNNGSSA-N C[C@@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1NC(C1C(C)(C)C1(C)C)=O Chemical compound C[C@@H](CCC1)N1[C@@H](CC1)CN1c(cc1)cc(C)c1NC(C1C(C)(C)C1(C)C)=O CJJRTJUBMZIMQU-HKUYNNGSSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98059907P | 2007-10-17 | 2007-10-17 | |
| US60/980,599 | 2007-10-17 | ||
| PCT/US2008/079757 WO2009052062A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010119528A RU2010119528A (ru) | 2011-11-27 |
| RU2477720C2 true RU2477720C2 (ru) | 2013-03-20 |
Family
ID=40247942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010119528/04A RU2477720C2 (ru) | 2007-10-17 | 2008-10-14 | Замещенные n-фенилбипирролидинкарбоксамиды и их применение в лечебных целях |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8088808B2 (OSRAM) |
| EP (1) | EP2212283B1 (OSRAM) |
| JP (1) | JP5377503B2 (OSRAM) |
| KR (1) | KR20100072077A (OSRAM) |
| CN (1) | CN101903340B (OSRAM) |
| AT (1) | ATE525351T1 (OSRAM) |
| AU (1) | AU2008312635B2 (OSRAM) |
| BR (1) | BRPI0818581A2 (OSRAM) |
| CA (1) | CA2702467C (OSRAM) |
| CY (1) | CY1112083T1 (OSRAM) |
| DK (1) | DK2212283T3 (OSRAM) |
| ES (1) | ES2372332T3 (OSRAM) |
| HR (1) | HRP20110762T1 (OSRAM) |
| IL (1) | IL205001A (OSRAM) |
| MA (1) | MA31858B1 (OSRAM) |
| MX (1) | MX2010003949A (OSRAM) |
| MY (1) | MY151348A (OSRAM) |
| NZ (1) | NZ584690A (OSRAM) |
| PL (1) | PL2212283T3 (OSRAM) |
| PT (1) | PT2212283E (OSRAM) |
| RS (1) | RS52235B (OSRAM) |
| RU (1) | RU2477720C2 (OSRAM) |
| SI (1) | SI2212283T1 (OSRAM) |
| WO (1) | WO2009052062A1 (OSRAM) |
| ZA (1) | ZA201002115B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0818626A2 (pt) | 2007-10-17 | 2015-09-29 | Sanofi Aventis | n-fenil-bipirrolidina carboxamidas substituída e uso terapêutico da mesma |
| SI2215058T1 (sl) | 2007-10-17 | 2012-03-30 | Sanofi Sa | Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba |
| SI2212283T1 (sl) * | 2007-10-17 | 2011-12-30 | Sanofi Sa | Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba |
| AU2008312636B2 (en) | 2007-10-17 | 2013-03-14 | Sanofi-Aventis | Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine H3 receptor modulators |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| SA110310332B1 (ar) * | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| WO2011143162A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| TW201206910A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
| JP5833105B2 (ja) * | 2010-05-11 | 2015-12-16 | サノフイ | 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用 |
| EP2569296A1 (en) * | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| TW201206444A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| ES2527466T3 (es) * | 2010-07-06 | 2015-01-26 | Astrazeneca Ab | Agentes terapéuticos 976 |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| JP2013232564A (ja) * | 2012-04-27 | 2013-11-14 | National Institute Of Advanced Industrial & Technology | 半導体装置および半導体装置の製造方法 |
| CN103694163A (zh) * | 2012-09-27 | 2014-04-02 | 上海先声药物研究有限公司 | 作为钾通道调节剂的化合物 |
| EA201500736A1 (ru) | 2013-01-10 | 2016-04-29 | Грюненталь Гмбх | Пиразолилкарбоксамиды i в качестве ингибиторов crac каналов |
| HK1216301A1 (zh) | 2013-01-10 | 2016-11-04 | Grünenthal GmbH | 作为crac通道抑制剂的基於吡唑基的甲醯胺ii |
| EP3366683A1 (en) | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004037257A1 (en) * | 2002-10-23 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| WO2006107661A1 (en) * | 2005-04-01 | 2006-10-12 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| WO2007005503A1 (en) * | 2005-07-01 | 2007-01-11 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| WO2007048595A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| RU2301231C2 (ru) * | 2000-10-17 | 2007-06-20 | Шеринг Корпорейшн | Полициклическое соединение, фармацевтическая композиция, обладающая свойствами антагониста рецептора h3, и способ лечения с его применением |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CN101142180B (zh) | 2005-03-17 | 2011-05-04 | 伊莱利利公司 | 作为组胺h3受体拮抗剂的吡咯烷衍生物 |
| EP1987020B1 (en) * | 2006-02-15 | 2012-10-03 | Sanofi | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| SI2212283T1 (sl) * | 2007-10-17 | 2011-12-30 | Sanofi Sa | Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba |
| SI2215058T1 (sl) | 2007-10-17 | 2012-03-30 | Sanofi Sa | Substituirane N fenil bipirolidin sečnine in njihova terapevtska uporaba |
| AU2008312636B2 (en) | 2007-10-17 | 2013-03-14 | Sanofi-Aventis | Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine H3 receptor modulators |
| BRPI0818626A2 (pt) | 2007-10-17 | 2015-09-29 | Sanofi Aventis | n-fenil-bipirrolidina carboxamidas substituída e uso terapêutico da mesma |
-
2008
- 2008-10-14 SI SI200830416T patent/SI2212283T1/sl unknown
- 2008-10-14 EP EP08839959A patent/EP2212283B1/en active Active
- 2008-10-14 MX MX2010003949A patent/MX2010003949A/es active IP Right Grant
- 2008-10-14 KR KR1020107010769A patent/KR20100072077A/ko not_active Ceased
- 2008-10-14 NZ NZ584690A patent/NZ584690A/en not_active IP Right Cessation
- 2008-10-14 MY MYPI20101299 patent/MY151348A/en unknown
- 2008-10-14 WO PCT/US2008/079757 patent/WO2009052062A1/en not_active Ceased
- 2008-10-14 HR HR20110762T patent/HRP20110762T1/hr unknown
- 2008-10-14 CN CN2008801212081A patent/CN101903340B/zh not_active Expired - Fee Related
- 2008-10-14 BR BRPI0818581-6A patent/BRPI0818581A2/pt not_active IP Right Cessation
- 2008-10-14 CA CA2702467A patent/CA2702467C/en not_active Expired - Fee Related
- 2008-10-14 PT PT08839959T patent/PT2212283E/pt unknown
- 2008-10-14 DK DK08839959.7T patent/DK2212283T3/da active
- 2008-10-14 ES ES08839959T patent/ES2372332T3/es active Active
- 2008-10-14 RU RU2010119528/04A patent/RU2477720C2/ru not_active IP Right Cessation
- 2008-10-14 AT AT08839959T patent/ATE525351T1/de active
- 2008-10-14 JP JP2010530049A patent/JP5377503B2/ja not_active Expired - Fee Related
- 2008-10-14 AU AU2008312635A patent/AU2008312635B2/en not_active Ceased
- 2008-10-14 RS RS20110522A patent/RS52235B/sr unknown
- 2008-10-14 PL PL08839959T patent/PL2212283T3/pl unknown
-
2010
- 2010-03-15 US US12/724,028 patent/US8088808B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02115A patent/ZA201002115B/en unknown
- 2010-04-11 IL IL205001A patent/IL205001A/en not_active IP Right Cessation
- 2010-05-17 MA MA32850A patent/MA31858B1/fr unknown
-
2011
- 2011-11-18 US US13/299,574 patent/US8252824B2/en not_active Expired - Fee Related
- 2011-11-24 CY CY20111101151T patent/CY1112083T1/el unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2301231C2 (ru) * | 2000-10-17 | 2007-06-20 | Шеринг Корпорейшн | Полициклическое соединение, фармацевтическая композиция, обладающая свойствами антагониста рецептора h3, и способ лечения с его применением |
| WO2004037257A1 (en) * | 2002-10-23 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| WO2006107661A1 (en) * | 2005-04-01 | 2006-10-12 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| WO2007005503A1 (en) * | 2005-07-01 | 2007-01-11 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| WO2007048595A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20151015 |