RU2463038C2 - Диклофенаковый гель - Google Patents
Диклофенаковый гель Download PDFInfo
- Publication number
- RU2463038C2 RU2463038C2 RU2009118392/15A RU2009118392A RU2463038C2 RU 2463038 C2 RU2463038 C2 RU 2463038C2 RU 2009118392/15 A RU2009118392/15 A RU 2009118392/15A RU 2009118392 A RU2009118392 A RU 2009118392A RU 2463038 C2 RU2463038 C2 RU 2463038C2
- Authority
- RU
- Russia
- Prior art keywords
- composition
- gel
- diclofenac
- compositions
- diclofenac sodium
- Prior art date
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- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title claims description 45
- 229960001259 diclofenac Drugs 0.000 title claims description 43
- 239000000203 mixture Substances 0.000 claims abstract description 281
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 120
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 115
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 104
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 101
- 239000002562 thickening agent Substances 0.000 claims abstract description 57
- 201000008482 osteoarthritis Diseases 0.000 claims abstract description 50
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 40
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- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 37
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000003814 drug Substances 0.000 claims abstract description 34
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- 239000000126 substance Substances 0.000 claims abstract description 22
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 18
- 208000002193 Pain Diseases 0.000 claims abstract description 17
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 claims abstract description 13
- 208000006820 Arthralgia Diseases 0.000 claims abstract description 9
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- 229960001193 diclofenac sodium Drugs 0.000 claims description 91
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims description 91
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- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 6
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- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
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- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
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- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
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| RU2637420C2 (ru) * | 2012-10-22 | 2017-12-04 | Нуво Фармасьютикалз Инк. | Система дозированного распределения |
| RU2677892C2 (ru) * | 2012-12-17 | 2019-01-22 | Лабораториос Охер Фарма, С.Л. | Гелевые композиции |
| RU2711090C2 (ru) * | 2015-01-23 | 2020-01-15 | Др. Редди'С Лабораториз Лимитед | Неокрашивающая гелевая композиция, содержащая нимесулид, для местного применения |
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| US8435224B2 (en) | 2005-09-12 | 2013-05-07 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds |
| WO2007033082A2 (en) | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (dmso) |
| JP5399072B2 (ja) | 2005-09-12 | 2014-01-29 | アベラ ファーマスーティカルズ インコーポレイテッド | ジメチルスルホキシド(dmso)若しくは関連化合物、又はそれに関連する臭気を除去するシステム |
| US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
| CA2666398C (en) | 2006-10-17 | 2015-08-18 | Ed Kisak | Diclofenac gel |
| US20100100060A1 (en) * | 2008-10-17 | 2010-04-22 | Novartis Ag | Applicator for pharmaceutical product and method of using same |
| BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
| US8618164B2 (en) | 2009-03-31 | 2013-12-31 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
| US8546450B1 (en) | 2009-03-31 | 2013-10-01 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
| EP2482850A2 (en) * | 2009-09-30 | 2012-08-08 | Nuvo Research Inc. | Topical formulations |
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| AU2010313253B2 (en) | 2009-10-30 | 2015-02-19 | Abela Pharmaceuticals, Inc. | Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis |
| WO2011060195A2 (en) | 2009-11-11 | 2011-05-19 | Nuvo Research Inc. | Topical eutectic formulation |
| EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| CA2828086C (en) | 2010-03-10 | 2018-07-31 | Nuvo Research Inc. | Foamable formulation |
| WO2011149645A1 (en) | 2010-05-28 | 2011-12-01 | Nuvo Research Inc. | Topical etoricoxib formulation |
| RU2013157834A (ru) * | 2011-05-26 | 2015-07-10 | Новартис Аг | Композиции для подкожного введения физиологически активных средств |
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| RU2637420C2 (ru) * | 2012-10-22 | 2017-12-04 | Нуво Фармасьютикалз Инк. | Система дозированного распределения |
| RU2677892C2 (ru) * | 2012-12-17 | 2019-01-22 | Лабораториос Охер Фарма, С.Л. | Гелевые композиции |
| RU2711090C2 (ru) * | 2015-01-23 | 2020-01-15 | Др. Редди'С Лабораториз Лимитед | Неокрашивающая гелевая композиция, содержащая нимесулид, для местного применения |
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