RU2458691C2 - Лечение посттравматического стрессового расстройства - Google Patents

Лечение посттравматического стрессового расстройства Download PDF

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Publication number
RU2458691C2
RU2458691C2 RU2010106014/15A RU2010106014A RU2458691C2 RU 2458691 C2 RU2458691 C2 RU 2458691C2 RU 2010106014/15 A RU2010106014/15 A RU 2010106014/15A RU 2010106014 A RU2010106014 A RU 2010106014A RU 2458691 C2 RU2458691 C2 RU 2458691C2
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RU
Russia
Prior art keywords
nepicastat
difluoro
thioxo
aminomethyl
dihydro
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RU2010106014/15A
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English (en)
Russian (ru)
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RU2010106014A (ru
Inventor
Том ВОЙВОДЕ (US)
Том ВОЙВОДЕ
Марк МОРАН (US)
Марк Моран
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Синошиа Терапьютикс
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Publication of RU2010106014A publication Critical patent/RU2010106014A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2010106014/15A 2007-07-23 2008-07-23 Лечение посттравматического стрессового расстройства RU2458691C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93503607P 2007-07-23 2007-07-23
US60/935,036 2007-07-23

Publications (2)

Publication Number Publication Date
RU2010106014A RU2010106014A (ru) 2011-08-27
RU2458691C2 true RU2458691C2 (ru) 2012-08-20

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RU2010106014/15A RU2458691C2 (ru) 2007-07-23 2008-07-23 Лечение посттравматического стрессового расстройства

Country Status (12)

Country Link
US (1) US20090054403A1 (OSRAM)
EP (1) EP2182952A4 (OSRAM)
JP (1) JP2010534676A (OSRAM)
CN (1) CN101951912A (OSRAM)
AU (1) AU2008279091A1 (OSRAM)
CA (1) CA2707858A1 (OSRAM)
CO (1) CO6260078A2 (OSRAM)
MX (1) MX2010000937A (OSRAM)
NZ (1) NZ583193A (OSRAM)
RU (1) RU2458691C2 (OSRAM)
SG (1) SG183069A1 (OSRAM)
WO (1) WO2009015248A1 (OSRAM)

Cited By (1)

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RU2614697C1 (ru) * 2016-04-12 2017-03-28 Общество с ограниченной ответственностью "Нормофарм" Нейропротекторное средство

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SG10201705968RA (en) * 2007-08-06 2017-08-30 Biotie Therapies Inc Methods for treating dependence
AU2016208412A1 (en) * 2007-08-06 2016-08-18 Biotie Therapies, Inc. Methods for treating dependence
WO2011062614A1 (en) * 2009-11-20 2011-05-26 Tonix Pharmaceuticals, Inc. Methods and compositions for treating symptoms associated with post-traumatic stress disorder using cyclobenzaprine
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
NZ747040A (en) 2013-03-15 2020-02-28 Tonix Pharmaceuticals Inc Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride
US11885816B2 (en) * 2013-11-26 2024-01-30 University Of North Texas Health Science Center At Forth Worth Personalized medicine approach for treating cognitive loss
SG11201701995PA (en) 2014-09-18 2017-04-27 Tonix Pharma Holdings Ltd Eutectic formulations of cyclobenzaprine hydrochloride
JOP20190049A1 (ar) 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز
CN110996987A (zh) * 2017-05-30 2020-04-10 保罗·G·爱默生 用于调控应激障碍中激素级联的组合物和方法
US11284934B2 (en) * 2017-07-05 2022-03-29 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating sleep disorders in patients via renal neuromodulation
JP7167155B2 (ja) 2017-12-04 2022-11-08 ビアル-ポルテラ エ コンパニア,ソシエダッド アノニマ ドーパミン-β-ヒドロキシラーゼ阻害剤
AU2018383098B2 (en) 2017-12-11 2024-12-12 Tonix Pharma Limited Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions
CN109966281B (zh) * 2019-04-11 2021-04-27 北京大学 PAO作为Pi4KIIα抑制剂在制备治疗创伤后应激障碍药物中的应用
EP4005566B1 (en) * 2019-07-25 2024-10-30 Tokyo University of Science Foundation Disulfiram and related compounds for treating, preventing or improving anxiety disorders or symptoms, and depressive disorders or symptoms
AU2023400662A1 (en) * 2022-11-30 2025-06-19 Blinklab Ltd Psychopharmacological system and method using eyelid tracking

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WO2003022283A1 (en) * 2001-09-13 2003-03-20 Schering Corporation Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic
EP1336406A1 (en) * 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity
CN1662231A (zh) * 2002-04-24 2005-08-31 柏树生物科学公司 包括应激相关障碍在内的功能性躯体障碍的预防与治疗
EP1734920A2 (en) * 2004-02-13 2006-12-27 Neuromolecular Inc. Combination of a nmda receptor antagonist and an mao-inhibitor or a gadph-inhibitor for the treatment of psychiatric conditions
JP2008531714A (ja) * 2005-03-04 2008-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 不安障害の治療用及び/又は予防用の医薬組成物
MX2008000248A (es) * 2005-07-06 2008-03-19 Sepracor Inc Combinaciones de eszopiclona y un antidepresivo y metodos de tratamiento contra la menopausia y trastornos del estado de animo, la ansiedad y trastornos cognitivos.
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КОСОВА Е.Г. Психическая ригидность как фактор развития посттравматического стрессового расстройства у сотрудников оперативных подразделений, перенесших боевой стресс. Диссертация. - Томск, 2005. PETRAKIS I.L. et al. Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder. Biol Psychiatry. 2006 Oct 1; 60(7):777-783. STANLEY W.C. et al. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug; 121(8): 1803-1809. HAMNER M.B. Plasma dopamine beta-hydroxylase activity in psychotic and non-psychotic post-traumatic stress disorder. Psychiatry Res. 1998 Feb 27; 77(3): 175-181. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2614697C1 (ru) * 2016-04-12 2017-03-28 Общество с ограниченной ответственностью "Нормофарм" Нейропротекторное средство

Also Published As

Publication number Publication date
NZ583193A (en) 2012-05-25
US20090054403A1 (en) 2009-02-26
WO2009015248A1 (en) 2009-01-29
MX2010000937A (es) 2010-06-25
CA2707858A1 (en) 2009-01-29
SG183069A1 (en) 2012-08-30
CN101951912A (zh) 2011-01-19
EP2182952A4 (en) 2010-09-08
CO6260078A2 (es) 2011-03-22
JP2010534676A (ja) 2010-11-11
RU2010106014A (ru) 2011-08-27
EP2182952A1 (en) 2010-05-12
AU2008279091A1 (en) 2009-01-29

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Effective date: 20130724